TNPO1 and ELAVL1

Number of citations of the paper that reports this interaction (PubMedID 15037768)
42

Data Source:
HPRD (in vitro, in vivo)

		TNPO1	ELAVL1
Description		transportin 1	ELAV like RNA binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Nuclear Lumen Extracellular Exosome	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Sarcoplasm Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity LncRNA Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport	LncRNA-mediated Post-transcriptional Gene Silencing Protein Import Into Nucleus Cell Population Proliferation Response To Glucose Positive Regulation Of Autophagy Post-transcriptional Gene Silencing Positive Regulation Of Superoxide Anion Generation Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Autophagosome Size MRNA Stabilization Protein Homooligomerization Negative Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance
Pathways		Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Intraflagellar transport Postmitotic nuclear pore complex (NPC) reformation	HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Factor VIII levels ( 30586737) Height ( 31562340) Hemoglobin ( 32888494) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252 29403010 32888494) Mean platelet volume ( 27863252 32888494) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red cell distribution width ( 28957414 32888494) Serum albumin levels ( 29403010) vWF levels ( 30586737)
Interacting Genes		19 interacting genes: ELAVL1 H2BC21 H3-4 HNRNPA1 HNRNPD NUP153 NUP214 NUP98 NXF1 PABPN1 RAN RANBP2 RGPD5 RNF10 RPL23A RPL5 RPS7 SRP19 ULK2	44 interacting genes: AKT1 ANP32A ANP32B APOE C12orf75 CARM1 CEBPA CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL6 IL7R KPNA1 KPNB1 LINC00460 LINC00632 MIRLET7B MIRLET7I NEIL3 NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SHANK3 SREK1 TNPO1 TNPO2 TRIM21 VCP VEGFA
Entrez ID		3842	1994
HPRD ID		04210	16025
Ensembl ID		ENSG00000083312	ENSG00000066044
Uniprot IDs		A0A7P0TBF0 Q92973	Q15717
PDB IDs		1QBK 2H4M 2OT8 2QMR 2Z5J 2Z5K 2Z5M 2Z5N 2Z5O 4FDD 4FQ3 4JLQ 4OO6 5J3V 5TQC 5YVG 5YVH 5YVI 7CYL 7VPW 8SGH	3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Import Into Nucleus Nuclear Export Nuclear Inclusion Body RNA Export From Nucleus RNA Transport Nuclear Pore Nucleobase-containing Compound Transport Protein Import Into Nucleus MRNA Transport Ribonucleoprotein Complex Protein Localization To Nucleus Establishment Of Protein Localization To Organelle RNA Binding Nuclear Envelope Cellular Localization Intracellular Transport Nuclear Pore Nuclear Basket Nucleoplasm Intracellular Protein Transport Establishment Of Localization In Cell Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Protein Localization To Organelle Establishment Of Protein Localization Nucleus Cytosolic Ribosome Nuclear Pore Cytoplasmic Filaments Negative Regulation Of RNA Export From Nucleus Regulation Of Nucleocytoplasmic Transport Protein Transport MRNA 3'-UTR Binding Cytosol Negative Regulation Of Ubiquitin Protein Ligase Activity Intracellular Protein Localization Nuclear Pore Complex Assembly MRNA Export From Nucleus Negative Regulation Of Ubiquitin-protein Transferase Activity Nuclear Export Signal Receptor Activity Ubiquitin Ligase Inhibitor Activity Nuclear Pore Organization MRNA Binding Nuclear Periphery Regulation Of RNA Export From Nucleus Regulation Of Intracellular Transport Pore Complex Assembly Protein-containing Complex Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Poly(A)+ MRNA Export From Nucleus	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Import Signal Receptor Activity Regulation Of Signal Transduction Regulation Of Platelet Activation Nuclear Localization Sequence Binding Regulation Of Macromolecule Metabolic Process Stress Granule Disassembly Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Blood Coagulation Positive Regulation Of Catabolic Process Intracellular Signaling Cassette Regulation Of Fat Cell Differentiation Regulation Of Hemostasis Regulation Of Wound Healing Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Response To Wounding Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity
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