TNPO1 and NUP153

Number of citations of the paper that reports this interaction (PubMedID 10202161)
91

Data Source:
HPRD (in vitro)

		TNPO1	NUP153
Description		transportin 1	nucleoporin 153
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Nuclear Lumen Extracellular Exosome	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Nuclear Basket
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity	DNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-membrane Adaptor Activity Metal Ion Binding Molecular Condensate Scaffold Activity
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Symbiont Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Viral Penetration Into Host Nucleus Amyloid Fibril Formation
Pathways		Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Intraflagellar transport Postmitotic nuclear pore complex (NPC) reformation	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Factor VIII levels ( 30586737) Height ( 31562340) Hemoglobin ( 32888494) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252 29403010 32888494) Mean platelet volume ( 27863252 32888494) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red cell distribution width ( 28957414 32888494) Serum albumin levels ( 29403010) vWF levels ( 30586737)	Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951) Obesity-related traits ( 23251661)
Interacting Genes		19 interacting genes: ELAVL1 H2BC21 H3-4 HNRNPA1 HNRNPD NUP153 NUP214 NUP98 NXF1 PABPN1 RAN RANBP2 RGPD5 RNF10 RPL23A RPL5 RPS7 SRP19 ULK2	29 interacting genes: APC BRCA1 CEBPA CLK1 DNMT3A DYNLT1 FILNC1 GRSF1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 NUP62 NXF1 NXF2 PTGER4 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-7 XPO1 XPO5 XPO7 XPOT
Entrez ID		3842	9972
HPRD ID		04210	04899
Ensembl ID		ENSG00000083312	ENSG00000124789
Uniprot IDs		A0A7P0TBF0 Q92973	P49790
PDB IDs		1QBK 2H4M 2OT8 2QMR 2Z5J 2Z5K 2Z5M 2Z5N 2Z5O 4FDD 4FQ3 4JLQ 4OO6 5J3V 5TQC 5YVG 5YVH 5YVI 7CYL 7VPW 8SGH	2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D 5TSV 5TSX 6AYA 8CKY 8CL0 9CNU
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Import Into Nucleus Nuclear Export Nuclear Inclusion Body RNA Export From Nucleus RNA Transport Nuclear Pore Nucleobase-containing Compound Transport Protein Import Into Nucleus MRNA Transport Ribonucleoprotein Complex Protein Localization To Nucleus Establishment Of Protein Localization To Organelle RNA Binding Nuclear Envelope Cellular Localization Intracellular Transport Nuclear Pore Nuclear Basket Nucleoplasm Intracellular Protein Transport Establishment Of Localization In Cell Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Protein Localization To Organelle Establishment Of Protein Localization Nucleus Cytosolic Ribosome Nuclear Pore Cytoplasmic Filaments Negative Regulation Of RNA Export From Nucleus Regulation Of Nucleocytoplasmic Transport Protein Transport MRNA 3'-UTR Binding Cytosol Negative Regulation Of Ubiquitin Protein Ligase Activity Intracellular Protein Localization Nuclear Pore Complex Assembly MRNA Export From Nucleus Negative Regulation Of Ubiquitin-protein Transferase Activity Nuclear Export Signal Receptor Activity Ubiquitin Ligase Inhibitor Activity Nuclear Pore Organization MRNA Binding Nuclear Periphery Regulation Of RNA Export From Nucleus Regulation Of Intracellular Transport Pore Complex Assembly Protein-containing Complex Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Poly(A)+ MRNA Export From Nucleus	Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore RNA Transport Nuclear Export RNA Export From Nucleus Nucleobase-containing Compound Transport Protein Transport Establishment Of Protein Localization Regulation Of Intracellular Transport Protein Localization To Nucleus Intracellular Protein Transport Protein Import Into Nucleus Nucleoplasm Import Into Nucleus Protein Export From Nucleus Intracellular Transport Nuclear Export Signal Receptor Activity Positive Regulation Of Protein Import Into Nucleus Intracellular Protein Localization Establishment Of Localization In Cell RNA Import Into Nucleus Nuclear Import Signal Receptor Activity Regulation Of Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Nuclear Envelope MRNA Transport RNA Binding Cellular Localization Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Nuclear Membrane Positive Regulation Of Intracellular Protein Transport Small GTPase Binding Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Protein Localization To Organelle Phosphatase Binding Response To Tumor Necrosis Factor Regulation Of Ossification MAP Kinase Activity RNA Nuclear Export Complex Pre-miRNA Export From Nucleus Regulation Of Cytoskeleton Organization MRNA Export From Nucleus Cytoplasm
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