ARHGAP10 and PKN3

Number of citations of the paper that reports this interaction (PMID 11432776)
10

Data Source:
HPRD (in vitro)

		ARHGAP10	PKN3
Gene Name		Rho GTPase activating protein 10	protein kinase N3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Nucleus Golgi Apparatus Perinuclear Region Of Cytoplasm
	Molecular Function	Rho GTPase Activator Activity Protein Binding	Protein Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding
	Biological Process	Apoptotic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction	Protein Phosphorylation Signal Transduction Epithelial Cell Migration
Pathways		Rho GTPase cycle Regulation of PAK-2p34 activity by PS-GAP/RHG10 Signaling by Rho GTPases Programmed Cell Death Regulation of Apoptosis
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502) QT interval ( 20031603)	Eating disorders (purging via substances) ( 23568457) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: CDC42 PAK2 PKN1 PKN3 RHOA YWHAQ	3 interactors: ARHGAP10 ARHGAP26 PLD1
Entrez ID		79658	29941
HPRD ID		07949	17856
Ensembl ID		ENSG00000071205	ENSG00000160447
Uniprot IDs		A1A4S6	Q6P5Z2
PDB IDs
Enriched GO Terms of Interacting Partners?		Substantia Nigra Development Neural Nucleus Development Midbrain Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Intracellular Signal Transduction Positive Regulation Of Intracellular Transport Cell Migration Cell Motility Positive Regulation Of Cytokinesis Axon Guidance Regulation Of Cytokinesis Regulation Of Intracellular Transport Regulation Of Signal Transduction Signal Transduction T Cell Costimulation Positive Regulation Of Kinase Activity Signaling Regulation Of Signaling Cell Communication Axonogenesis Positive Regulation Of Transferase Activity Ephrin Receptor Signaling Pathway Epithelial Cell Migration Axon Development Epithelium Migration Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Death Neuron Projection Morphogenesis Positive Regulation Of JNK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Division Regulation Of Establishment Of Protein Localization Positive Regulation Of Stress-activated MAPK Cascade Cellular Response To Stimulus Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Hair Follicle Cell Proliferation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Regulation Of Protein Kinase Activity Brain Development Positive Regulation Of Intracellular Protein Transport Regulation Of Kinase Activity	Small GTPase Mediated Signal Transduction Maintenance Of Golgi Location Positive Regulation Of Rho GTPase Activity Regulation Of Rho GTPase Activity Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Microvillus Assembly Establishment Of Golgi Localization Positive Regulation Of Ras GTPase Activity Endomembrane System Organization Phosphatidylglycerol Biosynthetic Process Regulation Of Ras GTPase Activity Golgi Localization Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Positive Regulation Of Hydrolase Activity Cytoskeleton Organization Organelle Transport Along Microtubule Defense Response To Gram-positive Bacterium Golgi Organization Signal Transduction Positive Regulation Of Catalytic Activity Signaling
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