ARHGAP10

Description		Rho GTPase activating protein 10
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Regulation of PAK-2p34 activity by PS-GAP/RHG10 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) QT interval ( 20031603) Resting heart rate ( 27798624) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		11 interacting genes: ANKS1A ARF6 CDC42 HRAS KLHL20 PAK2 PKN1 PKN3 RHOA SH3BP2 YWHAQ
Entrez ID		79658
HPRD ID		07949
Ensembl ID		ENSG00000071205
Uniprot IDs		A0A2X0SFB3 A1A4S6
PDB IDs		2MIO
Enriched GO Terms of Interacting Partners?		G Protein Activity Establishment Of Epithelial Cell Polarity Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Positive Regulation Of Cytokinesis Substantia Nigra Development Midbody Focal Adhesion Cleavage Furrow Neural Nucleus Development Cell Migration Regulation Of Cytoskeleton Organization Thioesterase Binding Regulation Of Actin Filament Organization Glutamatergic Synapse Small GTPase-mediated Signal Transduction Cell Motility Regulation Of Cytokinesis Nucleotide Binding Positive Regulation Of Cell Division Establishment Of Cell Polarity Regulation Of Stress Fiber Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Intracellular Signal Transduction GTPase Activity Regulation Of Cell Projection Organization Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity GTP Binding Regulation Of Supramolecular Fiber Organization Cytosol Ameboidal-type Cell Migration Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Signal Transduction Establishment Or Maintenance Of Cell Polarity Apoptotic Process Cell Junction Organization Positive Regulation Of Supramolecular Fiber Organization Cell Death Regulation Of Cell Division Programmed Cell Death Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelial Cell Migration Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Motility
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