ALDH5A1 and ABAT

Number of citations of the paper that reports this interaction (PubMedID 6470007)
0

Data Source:
HPRD (in vitro)

		ALDH5A1	ABAT
Description		aldehyde dehydrogenase 5 family member A1	4-aminobutyrate aminotransferase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Synapse	Mitochondrion Mitochondrial Matrix 4-aminobutyrate Transaminase Complex
	Molecular Function	Succinate-semialdehyde Dehydrogenase (NAD+) Activity Succinate-semialdehyde Dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding	Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding Succinate-semialdehyde Dehydrogenase Binding 4-aminobutyrate:2-oxoglutarate Transaminase Activity Identical Protein Binding Metal Ion Binding (S)-3-amino-2-methylpropionate Transaminase Activity Iron-sulfur Cluster Binding
	Biological Process	Succinate Metabolic Process Glutamate Metabolic Process Central Nervous System Development Gamma-aminobutyric Acid Metabolic Process Gamma-aminobutyric Acid Catabolic Process Post-embryonic Development Carboxylic Acid Metabolic Process Synaptic Transmission, GABAergic	Response To Hypoxia Copulation Locomotory Behavior Response To Xenobiotic Stimulus Gamma-aminobutyric Acid Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Gamma-aminobutyric Acid Catabolic Process Response To Iron Ion Negative Regulation Of Gamma-aminobutyric Acid Secretion Cerebellum Development Positive Regulation Of Heat Generation Positive Regulation Of Insulin Secretion Negative Regulation Of Dopamine Secretion Response To Nicotine Exploration Behavior Response To Cocaine Response To Ethanol Negative Regulation Of Blood Pressure Positive Regulation Of Dopamine Metabolic Process Nervous System Process Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Prolactin Secretion Positive Regulation Of Aspartate Secretion
Pathways		Degradation of GABA	Degradation of GABA
Drugs		Succinic acid NADH Valproic acid Chlormerodrin	Pyridoxal phosphate Pyruvic acid Glutamic acid Alanine Phenelzine Vigabatrin (4e)-4-Aminohex-4-Enoic Acid 4-Amino Hexanoic Acid
Diseases		Succinic semialdehyde dehydrogenase (SSADH) deficiency; 4-Hydroxybutyric aciduria (4-HBA)
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757)	Anger ( 24489884) Bronchopulmonary dysplasia in preterm infants ( 30113228) Menopause (age at onset) ( 26414677) Response to opioid analgesics in cancer (pain decrease) ( 30277654)
Interacting Genes		4 interacting genes: ABAT CLIC6 MAGEA11 OGT	1 interacting genes: ALDH5A1
Entrez ID		7915	18
HPRD ID		08361	00661
Ensembl ID		ENSG00000112294	ENSG00000183044
Uniprot IDs		P51649 X5D299 X5DQN2	H3BNQ7 P80404 X5D8S1
PDB IDs		2W8N 2W8O 2W8P 2W8Q 2W8R
Enriched GO Terms of Interacting Partners?		(S)-3-amino-2-methylpropionate Transaminase Activity Succinate-semialdehyde Dehydrogenase Binding 4-aminobutyrate Transaminase Complex 4-aminobutyrate:2-oxoglutarate Transaminase Activity Regulation Of Rac Protein Signal Transduction Erythrocyte Apoptotic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly D4 Dopamine Receptor Binding Positive Regulation Of Prolactin Secretion Gamma-aminobutyric Acid Catabolic Process Positive Regulation Of Aspartate Secretion Copulation Negative Regulation Of Gamma-aminobutyric Acid Secretion D3 Dopamine Receptor Binding Positive Regulation Of Protein Secretion Regulation Of Protein Localization To Cell Periphery Regulation Of Synapse Assembly Protein Localization To Cleavage Furrow Protein O-acetylglucosaminyltransferase Activity D2 Dopamine Receptor Binding Positive Regulation Of Dopamine Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Modulation Of Inhibitory Postsynaptic Potential Negative Regulation Of Dopamine Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Localization Positive Regulation Of Protein Transport Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Mitotic Cytokinetic Process Cellular Response To Diacyl Bacterial Lipopeptide Negative Regulation Of Dendrite Development Regulation Of Protein Localization To Membrane Maintenance Of Postsynaptic Density Structure Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Secretion Gamma-aminobutyric Acid Metabolic Process Regulation Of Cell Junction Assembly Positive Regulation Of Focal Adhesion Disassembly Regulation Of Uterine Smooth Muscle Contraction Regulation Of Transcription By Glucose Positive Regulation Of Heat Generation Positive Regulation Of Secretion By Cell Thioesterase Binding Positive Regulation Of Keratinocyte Migration Maintenance Of Postsynaptic Specialization Structure	Succinate-semialdehyde Dehydrogenase [NAD(P)+] Activity Succinate-semialdehyde Dehydrogenase (NAD+) Activity Gamma-aminobutyric Acid Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Glutamate Metabolic Process Synaptic Transmission, GABAergic Glutamine Family Amino Acid Metabolic Process Post-embryonic Development Dicarboxylic Acid Metabolic Process Amino Acid Catabolic Process Central Nervous System Development L-amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Mitochondrial Matrix Monocarboxylic Acid Metabolic Process
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