ALDH5A1

Description		aldehyde dehydrogenase 5 family member A1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Synapse
	Molecular Function	Succinate-semialdehyde Dehydrogenase (NAD+) Activity Succinate-semialdehyde Dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding
	Biological Process	Succinate Metabolic Process Glutamate Metabolic Process Central Nervous System Development Gamma-aminobutyric Acid Metabolic Process Gamma-aminobutyric Acid Catabolic Process Post-embryonic Development Carboxylic Acid Metabolic Process Synaptic Transmission, GABAergic
Pathways		Degradation of GABA
Drugs		Succinic acid NADH Valproic acid Chlormerodrin
Diseases		Succinic semialdehyde dehydrogenase (SSADH) deficiency; 4-Hydroxybutyric aciduria (4-HBA)
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757)
Novel Interacting Genes		1 novel interacting genes: ARF6
Interacting Genes		4 interacting genes: ABAT CLIC6 MAGEA11 OGT
Entrez ID		7915
HPRD ID		08361
Ensembl ID		ENSG00000112294
Uniprot IDs		P51649 X5D299 X5DQN2
PDB IDs		2W8N 2W8O 2W8P 2W8Q 2W8R
Enriched GO Terms of Interacting Partners?		(S)-3-amino-2-methylpropionate Transaminase Activity Succinate-semialdehyde Dehydrogenase Binding 4-aminobutyrate Transaminase Complex 4-aminobutyrate:2-oxoglutarate Transaminase Activity Regulation Of Rac Protein Signal Transduction Erythrocyte Apoptotic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly D4 Dopamine Receptor Binding Positive Regulation Of Prolactin Secretion Gamma-aminobutyric Acid Catabolic Process Positive Regulation Of Aspartate Secretion Copulation Negative Regulation Of Gamma-aminobutyric Acid Secretion D3 Dopamine Receptor Binding Positive Regulation Of Protein Secretion Regulation Of Protein Localization To Cell Periphery Regulation Of Synapse Assembly Protein Localization To Cleavage Furrow Protein O-acetylglucosaminyltransferase Activity D2 Dopamine Receptor Binding Positive Regulation Of Dopamine Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Modulation Of Inhibitory Postsynaptic Potential Negative Regulation Of Dopamine Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Localization Positive Regulation Of Protein Transport Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Mitotic Cytokinetic Process Cellular Response To Diacyl Bacterial Lipopeptide Negative Regulation Of Dendrite Development Regulation Of Protein Localization To Membrane Maintenance Of Postsynaptic Density Structure Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Secretion Gamma-aminobutyric Acid Metabolic Process Regulation Of Cell Junction Assembly Positive Regulation Of Focal Adhesion Disassembly Regulation Of Uterine Smooth Muscle Contraction Regulation Of Transcription By Glucose Positive Regulation Of Heat Generation Positive Regulation Of Secretion By Cell Thioesterase Binding Positive Regulation Of Keratinocyte Migration Maintenance Of Postsynaptic Specialization Structure
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