ALDH5A1 and MAGEA11

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		ALDH5A1	MAGEA11
Description		aldehyde dehydrogenase 5 family member A1	MAGE family member A11
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Succinate-semialdehyde Dehydrogenase (NAD+) Activity Succinate-semialdehyde Dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding	Protein Binding Histone Deacetylase Binding
	Biological Process	Succinate Metabolic Process Glutamate Metabolic Process Central Nervous System Development Gamma-aminobutyric Acid Metabolic Process Gamma-aminobutyric Acid Catabolic Process Post-embryonic Development Carboxylic Acid Metabolic Process Synaptic Transmission, GABAergic	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Degradation of GABA
Drugs		Succinic acid NADH Valproic acid Chlormerodrin
Diseases		Succinic semialdehyde dehydrogenase (SSADH) deficiency; 4-Hydroxybutyric aciduria (4-HBA)
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757)
Interacting Genes		4 interacting genes: ABAT CLIC6 MAGEA11 OGT	115 interacting genes: ACMSD ACSM2B ACTN1 AKR1C3 ALDH5A1 AR ARHGAP29 BCL2L11 BEX2 BIRC2 BRD1 C18orf54 C22orf39 CASP7 CAVIN3 CCDC106 CCDC14 CCDC146 CCDC185 CCDC27 CCNA2 CDC20B CDKN2B CEP76 CLUAP1 CORO1A COX7A2L CSNK2A1 CTTNBP2 DLGAP1 DNAJC10 DOCK10 ENOX2 EWSR1 FAM156A FAM161A FBXO46 GADD45GIP1 GCSH GNPDA1 HOXB5 IFI44 IL11 IL6ST ILF3 JADE3 KIAA0408 LMBR1L LNX1 MAPK3 MCRS1 MED28 MGME1 MLF1 MTA1 MXD3 MYOZ1 NCOA2 NDEL1 NDUFAF1 NDUFB9 NIF3L1 NOL4 NOS3 NSUN4 NTAQ1 OTUB2 PCBD2 PCF11 PDE4B PHYH PIK3IP1 PIN4 PLCXD3 PNKD PNKP POLR1D PPIF PPM1K PRDX3 PRKRIP1 PSMF1 RADIL RANBP10 RBM23 REX1BD SH2D4A SNX20 SNX7 SPMIP9 STAR SUCLA2 SUOX SUV39H2 TCEA2 TCEANC TCF25 TEKTL1 THEM5 TMEM123 TPM3 TRIM27 TRIM51 TRMT1 TXN2 UBE2D4 UBE3D USP20 UTP25 VTA1 WTAP ZBTB16 ZCCHC12 ZNF655 ZSWIM2
Entrez ID		7915	4110
HPRD ID		08361	02281
Ensembl ID		ENSG00000112294	ENSG00000185247
Uniprot IDs		P51649 X5D299 X5DQN2	G5E962 P43364
PDB IDs		2W8N 2W8O 2W8P 2W8Q 2W8R	6WJH
Enriched GO Terms of Interacting Partners?		(S)-3-amino-2-methylpropionate Transaminase Activity Succinate-semialdehyde Dehydrogenase Binding 4-aminobutyrate Transaminase Complex 4-aminobutyrate:2-oxoglutarate Transaminase Activity Regulation Of Rac Protein Signal Transduction Erythrocyte Apoptotic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly D4 Dopamine Receptor Binding Positive Regulation Of Prolactin Secretion Gamma-aminobutyric Acid Catabolic Process Positive Regulation Of Aspartate Secretion Copulation Negative Regulation Of Gamma-aminobutyric Acid Secretion D3 Dopamine Receptor Binding Positive Regulation Of Protein Secretion Regulation Of Protein Localization To Cell Periphery Regulation Of Synapse Assembly Protein Localization To Cleavage Furrow Protein O-acetylglucosaminyltransferase Activity D2 Dopamine Receptor Binding Positive Regulation Of Dopamine Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Modulation Of Inhibitory Postsynaptic Potential Negative Regulation Of Dopamine Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Localization Positive Regulation Of Protein Transport Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Mitotic Cytokinetic Process Cellular Response To Diacyl Bacterial Lipopeptide Negative Regulation Of Dendrite Development Regulation Of Protein Localization To Membrane Maintenance Of Postsynaptic Density Structure Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Secretion Gamma-aminobutyric Acid Metabolic Process Regulation Of Cell Junction Assembly Positive Regulation Of Focal Adhesion Disassembly Regulation Of Uterine Smooth Muscle Contraction Regulation Of Transcription By Glucose Positive Regulation Of Heat Generation Positive Regulation Of Secretion By Cell Thioesterase Binding Positive Regulation Of Keratinocyte Migration Maintenance Of Postsynaptic Specialization Structure	Mitochondrial Matrix Protein Binding Mitochondrion Catabolic Process
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