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TBC1D10C and KLHL12
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
TBC1D10C
KLHL12
Gene Name
TBC1 domain family, member 10C
kelch-like family member 12
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Membrane
Filopodium Membrane
Golgi Membrane
Cytosol
ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Molecular Function
Rab GTPase Activator Activity
Protein Binding
Biological Process
Positive Regulation Of Rab GTPase Activity
Retrograde Transport, Endosome To Golgi
Negative Regulation Of B Cell Activation
Negative Regulation Of NFAT Protein Import Into Nucleus
Negative Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cilium Assembly
Protein Monoubiquitination
ER To Golgi Vesicle-mediated Transport
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
APP
HOXA1
KLHL12
KRTAP13-1
KRTAP5-9
NOTCH2NL
PPP3R2
39 interactors:
ARAF
ATXN1
BAG6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CUL3
DGCR6
DRD4
DVL3
FGD2
FLNA
GLYCTK
INMT
KLHL2
KLHL3
LNX1
MED28
MPP1
MRPL10
NDC80
PDGFRB
PEF1
PRR13
RIT1
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TTBK2
UBE2I
VEGFB
VTA1
WDYHV1
ZBP1
Entrez ID
374403
59349
HPRD ID
13330
13925
Ensembl ID
ENSG00000175463
ENSG00000117153
Uniprot IDs
Q8IV04
Q53G59
PDB IDs
2VPJ
Enriched GO Terms of Interacting Partners
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Visual Behavior
Optokinetic Behavior
Abducens Nerve Formation
Neuromuscular Process
Notch Signaling Pathway
Facial Nucleus Development
Synaptic Growth At Neuromuscular Junction
Collateral Sprouting In Absence Of Injury
Rhombomere 4 Development
Semicircular Canal Formation
Rhombomere 3 Development
Rhombomere 5 Development
Collateral Sprouting
Axon Midline Choice Point Recognition
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Axon Choice Point Recognition
Cognition
Embryonic Neurocranium Morphogenesis
Neuron Remodeling
Response To Light Stimulus
Outer Ear Morphogenesis
Semicircular Canal Morphogenesis
Rhombomere Development
Facial Nerve Structural Organization
Pons Development
Axon Guidance
Facial Nerve Morphogenesis
Semicircular Canal Development
Response To Radiation
Single-organism Behavior
Cellular Copper Ion Homeostasis
COPII Vesicle Coating
Parasympathetic Nervous System Development
Anatomical Structure Arrangement
COPII-coated Vesicle Budding
Copper Ion Homeostasis
Suckling Behavior
Axonogenesis
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cochlea Morphogenesis
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Behavior
Chemotaxis
Neuron Maturation
MRNA Polyadenylation
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Vesicle Targeting, To, From Or Within Golgi
Neuron Projection Morphogenesis
Mating Behavior
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Coronary Vasculature Development
Actin Cytoskeleton Organization
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Chromosome Segregation
Actin Filament-based Process
Positive Regulation Of Catalytic Activity
Anatomical Structure Development
Cellular Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Modification-dependent Protein Catabolic Process
Cell Projection Assembly
Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Division
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Chemotaxis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
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Tagcloud (Intersection)
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