ANOS1 and FGFR3

Number of citations of the paper that reports this interaction (PubMedID 19696444)
48

Data Source:
BioGRID (pull down)

		ANOS1	FGFR3
Description		anosmin 1	fibroblast growth factor receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Extracellular Matrix	Extracellular Region Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Cell Surface Membrane Transport Vesicle Cytoplasmic Vesicle Receptor Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Peptidase Inhibitor Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Fibroblast Growth Factor Binding Identical Protein Binding
	Biological Process	Chemotaxis Cell Adhesion Axon Guidance Neuron Differentiation	MAPK Cascade Skeletal System Development Ossification Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Apoptotic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Bone Mineralization Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Negative Regulation Of Developmental Growth Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways		FGFR1c ligand binding and activation Negative regulation of FGFR1 signaling	Signaling by activated point mutants of FGFR3 t(4;14) translocations of FGFR3 Signaling by FGFR3 in disease Signaling by FGFR3 fusions in cancer
Drugs			XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Infigratinib Fostamatinib Erdafitinib Pemigatinib Futibatinib Selpercatinib
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)	CATSHL syndrome Multiple myeloma FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Bladder cancer
GWAS		Estimated glomerular filtration rate ( 31015462)	Bladder cancer ( 20972438 24163127) Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Urinary bladder cancer ( 20348956)
Interacting Genes		6 interacting genes: FGFR2 FGFR3 FN1 NCALD SDC2 UBQLN1	43 interacting genes: ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3
Entrez ID		3730	2261
HPRD ID		02393	00624
Ensembl ID		ENSG00000011201	ENSG00000068078
Uniprot IDs		P23352	F8W9L4 P22607 Q0IJ44 X5D2G8
PDB IDs		1ZLG	1RY7 2LZL 4K33 6LVM 6PNX 7DHL 7YSU 8UDT 8UDU 8UDV 9CD7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipase Activity Fibroblast Growth Factor Receptor Activity Positive Regulation Of Lipase Activity Endochondral Bone Growth Bone Growth Fibroblast Growth Factor Binding Bone Morphogenesis Identical Protein Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Developmental Growth Organ Growth Transmembrane Receptor Protein Tyrosine Kinase Activity Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Negative Regulation Of Store-operated Calcium Channel Activity Biomineral Tissue Development Regulation Of Signal Transduction Regulation Of Growth Positive Regulation Of Hydrolase Activity Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Bone Maturation Regulation Of Protein Modification Process Regulation Of MAPK Cascade Cell Surface Protein Tyrosine Kinase Activity Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Ventricular Zone Neuroblast Division Cellular Response To Decreased Oxygen Levels Prostate Epithelial Cord Elongation Cellular Response To Hypoxia Orbitofrontal Cortex Development Mammary Gland Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Branch Elongation Involved In Salivary Gland Morphogenesis Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Heparin Binding Cellular Response To Oxygen Levels Positive Regulation Of Developmental Growth Calcium-independent Cell-matrix Adhesion Regulation Of Cell Communication Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Prostate Gland Morphogenesis	Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Fibroblast Growth Factor Receptor Binding Growth Factor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Division Type 2 Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Regulation Of Cell Division Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cell Differentiation Positive Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Lung Development Mesenchymal Cell Proliferation Cellular Developmental Process Positive Regulation Of ERK1 And ERK2 Cascade Extracellular Space Regulation Of Signal Transduction Stem Cell Proliferation Positive Regulation Of MAP Kinase Activity Cell Population Proliferation Heparin Binding Negative Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Stem Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Corticotropin Hormone Secreting Cell Differentiation Angiogenesis Positive Regulation Of Cell Migration Regulation Of Anatomical Structure Morphogenesis Regulation Of Chemotaxis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?