KAL1 and SDC2

Number of citations of the paper that reports this interaction (PMID 8832397)
12

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KAL1	SDC2
Gene Name		Kallmann syndrome 1 sequence	syndecan 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Plasma Membrane	Golgi Lumen Plasma Membrane Integral Component Of Membrane Neuronal Cell Body Lysosomal Lumen Synapse
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Protein Binding Heparin Binding	Protein Binding PDZ Domain Binding
	Biological Process	Movement Of Cell Or Subcellular Component Chemotaxis Cell Adhesion Axon Guidance Negative Regulation Of Endopeptidase Activity	Retinoid Metabolic Process Response To Hypoxia Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Phototransduction, Visible Light Biological_process Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Response To Caffeine Wound Healing Small Molecule Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism EPHB-mediated forward signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D EPH-Ephrin signaling A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: SDC2	26 interactors: BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF KAL1 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		3730	6383
HPRD ID		02393	00803
Ensembl ID		ENSG00000011201	ENSG00000169439
Uniprot IDs		P23352	E9PBI9 P34741
PDB IDs		1ZLG
Enriched GO Terms of Interacting Partners?		Response To Caffeine Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Regulation Of Dendrite Morphogenesis Phototransduction, Visible Light Dendrite Morphogenesis Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Ephrin Receptor Signaling Pathway Glycosaminoglycan Biosynthetic Process Regulation Of Dendrite Development Proteoglycan Metabolic Process Detection Of Light Stimulus Isoprenoid Metabolic Process Dendrite Development Response To Alkaloid Response To Purine-containing Compound Glycosaminoglycan Metabolic Process Detection Of Abiotic Stimulus Pathogenesis Response To Hypoxia Response To Light Stimulus Sulfur Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Neuron Projection Development Axon Guidance	Regulation Of Body Fluid Levels Platelet Activation Wound Healing Response To Wounding Blood Coagulation Hemostasis Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Epithelial Cell Proliferation Cell Activation Regulation Of Angiogenesis Regulation Of Cell Migration Multicellular Organismal Development Regulation Of Epithelial Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Cell Proliferation Response To Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Locomotion Positive Regulation Of Signal Transduction System Development Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endothelial Cell Migration Anatomical Structure Development Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Wound Healing Regulation Of Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stress Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Migration Cell Development Histone H3-T6 Phosphorylation
Tagcloud ?		1g 27delc 7cases agenesis boy case17 choosen cryptorchidism deaf fgfr1 genitalia gonadotropin gynecomastia hypogonadism hypogonadotropic hyposmia hypospadias ihh inappropriately kallmann ks micropenis nihh palatal penis puberty smelling uncle visited	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Difference) ?		1g 27delc 7cases agenesis boy case17 choosen cryptorchidism deaf fgfr1 genitalia gonadotropin gynecomastia hypogonadism hypogonadotropic hyposmia hypospadias ihh inappropriately kallmann ks micropenis nihh palatal penis puberty smelling uncle visited	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Intersection) ?