ANOS1

Description		anosmin 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Peptidase Inhibitor Activity
	Biological Process	Chemotaxis Cell Adhesion Axon Guidance Neuron Differentiation
Pathways		FGFR1c ligand binding and activation Negative regulation of FGFR1 signaling
Drugs
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Estimated glomerular filtration rate ( 31015462)
Interacting Genes		6 interacting genes: FGFR2 FGFR3 FN1 NCALD SDC2 UBQLN1
Entrez ID		3730
HPRD ID		02393
Ensembl ID		ENSG00000011201
Uniprot IDs		P23352
PDB IDs		1ZLG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipase Activity Fibroblast Growth Factor Receptor Activity Positive Regulation Of Lipase Activity Endochondral Bone Growth Bone Growth Fibroblast Growth Factor Binding Bone Morphogenesis Identical Protein Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Developmental Growth Organ Growth Transmembrane Receptor Protein Tyrosine Kinase Activity Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Negative Regulation Of Store-operated Calcium Channel Activity Biomineral Tissue Development Regulation Of Signal Transduction Regulation Of Growth Positive Regulation Of Hydrolase Activity Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Bone Maturation Regulation Of Protein Modification Process Regulation Of MAPK Cascade Cell Surface Protein Tyrosine Kinase Activity Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Ventricular Zone Neuroblast Division Cellular Response To Decreased Oxygen Levels Prostate Epithelial Cord Elongation Cellular Response To Hypoxia Orbitofrontal Cortex Development Mammary Gland Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Branch Elongation Involved In Salivary Gland Morphogenesis Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Heparin Binding Cellular Response To Oxygen Levels Positive Regulation Of Developmental Growth Calcium-independent Cell-matrix Adhesion Regulation Of Cell Communication Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Prostate Gland Morphogenesis
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