JUP and PKD1

Number of citations of the paper that reports this interaction (PMID 11274246)
24

Data Source:
HPRD (in vivo, in vitro)

		JUP	PKD1
Gene Name		junction plakoglobin	polycystic kidney disease 1 (autosomal dominant)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Extracellular Vesicular Exosome Gamma-catenin-TCF7L2 Complex	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cilium Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Primary Cilium Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	Transcription Coactivator Activity Signal Transducer Activity Structural Molecule Activity Structural Constituent Of Cell Wall Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Ion Channel Binding
	Biological Process	Desmosome Assembly Cytoskeletal Anchoring At Plasma Membrane Single Organismal Cell-cell Adhesion Cell Migration Cell Junction Assembly Adherens Junction Organization Adherens Junction Assembly Regulation Of Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Regulation Of Cell Fate Specification Skin Development Cell-cell Junction Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Mechanical Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Heterooligomerization Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Canonical Wnt Signaling Pathway	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Nitrogen Compound Metabolic Process Organelle Organization Cell Cycle Arrest Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration JAK-STAT Cascade Heart Development Anatomical Structure Morphogenesis Single Organismal Cell-cell Adhesion Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Binding Response To Fluid Shear Stress Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis
Pathways		Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNBIP1 CTNND1 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 FER FHL2 FYN MUC1 NFATC4 NFKBIE PECAM1 PKD1 PKP2 PKP3 PSEN1 PTPN14 PTPRF PTPRJ PTPRK RIBC2 SRC TCF4 TCF7L2 WDYHV1 ZFYVE9	25 interactors: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 MARK2 PKD2 PTK2 PXN RGS7 SIAH1 SRC TLN1 VCL VIM
Entrez ID		3728	5310
HPRD ID		01414	03203
Ensembl ID		ENSG00000173801	ENSG00000008710
Uniprot IDs		P14923	P98161
PDB IDs		3IFQ	1B4R
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Cell-cell Junction Organization Adherens Junction Organization Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Cellular Component Movement Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Signaling Anatomical Structure Development Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cell Proliferation Regulation Of Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Anatomical Structure Morphogenesis Developmental Process Multicellular Organismal Development System Development Execution Phase Of Apoptosis Cardiovascular System Development Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Ventricular Cardiac Muscle Cell Action Potential Response To Organic Substance Response To Stress Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cell Motility Negative Regulation Of Cell Death Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Organ Morphogenesis Organ Development Cellular Component Assembly Regulation Of Locomotion Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cellular Component Organization Signal Transduction Regulation Of Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stress Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction	Adherens Junction Organization Cytoskeleton Organization Movement Of Cell Or Subcellular Component Cell Junction Assembly Cell-cell Junction Organization Cellular Response To Organonitrogen Compound Regulation Of Cellular Component Movement Organelle Organization Cellular Response To Organic Substance Cellular Response To Indole-3-methanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Activation Regulation Of Body Fluid Levels Response To Organic Substance Response To Organonitrogen Compound Blood Coagulation Regulation Of Cell Motility Hemostasis Anatomical Structure Development Cell Development Cell Adhesion Adherens Junction Assembly Cellular Component Assembly Regulation Of Locomotion Cell-cell Junction Assembly Cell Activation Response To Wounding Generation Of Neurons Cell Morphogenesis Involved In Differentiation Locomotion Anatomical Structure Morphogenesis Cell Differentiation Neurogenesis Multicellular Organismal Development Developmental Process System Development Response To Stimulus Regulation Of Cell Migration Wound Healing Actin Filament-based Process Nervous System Development Response To Peptide Hormone Cellular Localization Response To Stress Response To Peptide Cellular Response To Peptide Hormone Stimulus Protein Complex Assembly Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd2 polycystic polycystin progressive severity
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd2 polycystic polycystin progressive severity
Tagcloud (Intersection) ?