JUP and PKD1

Number of citations of the paper that reports this interaction (PubMedID 11274246)
0

Data Source:
HPRD (in vitro, in vivo)

		JUP	PKD1
Description		junction plakoglobin	polycystin 1, transient receptor potential channel interacting
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Anchoring Junction Catenin-TCF7L2 Complex Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen	Golgi Membrane Polycystin Complex Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Migrasome
	Molecular Function	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Nuclear Receptor Binding Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity	Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt Receptor Activity Transmembrane Transporter Binding Transcription Regulator Inhibitor Activity
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Adhesion Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Canonical Wnt Signaling Pathway Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Cartilage Condensation Blood Vessel Development In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Gene Expression Regulation Of Cell Cycle Process Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Response To Fluid Shear Stress Lymph Vessel Morphogenesis Chordate Embryonic Development Skin Development Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Cell Cycle Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Nitrogen Cycle Metabolic Process Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Adhesion Mitocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CDH11 homotypic and heterotypic interactions	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs		Zinc Zinc acetate
Diseases		Naxos disease and Carvajal syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Polycystic kidney disease
GWAS		Heel bone mineral density ( 28869591 30598549) Major depressive disorder x sex interaction ( 34099189)	Appendicular lean mass ( 33097823) Dilated cardiomyopathy ( 33677556) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		55 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HDAC1 HDAC2 HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9	31 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 RUNX1 SIAH1 SRC TLN1 VCL VIM
Entrez ID		3728	5310
HPRD ID		01414	03203
Ensembl ID		ENSG00000173801	ENSG00000008710
Uniprot IDs		A0A0S2Z487 P14923	P98161
PDB IDs		3IFQ	1B4R 6A70
Enriched GO Terms of Interacting Partners?		Beta-catenin Binding Desmosome Cell Junction Cell-cell Adhesion Gamma-catenin Binding Cell Junction Organization Anchoring Junction Cell Adhesion Cell-cell Junction Organization Adherens Junction Cell-cell Junction Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Junction Assembly Cadherin Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Catenin Complex Cornified Envelope Anatomical Structure Morphogenesis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cell Migration Cell Motility Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Positive Regulation Of Protein Localization Regulation Of Protein Localization To Cell-cell Junction Developmental Process Lateral Plasma Membrane Cell Surface Receptor Signaling Pathway Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Intracellular Signal Transduction Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Apoptotic Process Plasma Membrane Intercalated Disc	Anchoring Junction Focal Adhesion Cell-cell Junction Cellular Response To Indole-3-methanol Cell Junction Assembly Response To Indole-3-methanol Cell Surface Receptor Signaling Pathway Cell Migration Fascia Adherens Regulation Of Cell Adhesion Signal Complex Assembly Cell Adhesion Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Vinculin Binding Cell-cell Junction Assembly ERBB Signaling Pathway Regulation Of Cell Motility Cadherin Binding Regulation Of Cell-substrate Adhesion Cellular Response To Oxygen-containing Compound Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Cell Junction Organization Integrin-mediated Signaling Pathway Cell-cell Junction Organization Regulation Of Cell Migration Extrinsic Apoptotic Signaling Pathway Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Catenin Complex Signal Transduction Zonula Adherens Scaffold Protein Binding Flotillin Complex Cellular Response To Fluid Shear Stress Neuron Projection Development Alpha-catenin Binding Supramolecular Fiber Organization Cell-cell Adhesion Intermediate Filament Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoplasm Anatomical Structure Morphogenesis Response To Fluid Shear Stress
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