JUP and CDH1

Number of citations of the paper that reports this interaction (PMID 8207061)
131

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		JUP	CDH1
Gene Name		junction plakoglobin	cadherin 1, type 1, E-cadherin (epithelial)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Extracellular Vesicular Exosome Gamma-catenin-TCF7L2 Complex	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cell-cell Adherens Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Aggresome Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Cell Junction Node Of Ranvier Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Axon Terminus Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Signal Transducer Activity Structural Molecule Activity Structural Constituent Of Cell Wall Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Protein Domain Specific Binding Ankyrin Binding GTPase Activating Protein Binding Gamma-catenin Binding Cell Adhesion Molecule Binding
	Biological Process	Desmosome Assembly Cytoskeletal Anchoring At Plasma Membrane Single Organismal Cell-cell Adhesion Cell Migration Cell Junction Assembly Adherens Junction Organization Adherens Junction Assembly Regulation Of Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Regulation Of Cell Fate Specification Skin Development Cell-cell Junction Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Mechanical Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Heterooligomerization Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Canonical Wnt Signaling Pathway	Trophectodermal Cell Differentiation Epithelial Cell Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Sensory Perception Of Sound Response To Toxic Substance Single Organismal Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Protein Metabolic Process Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neuron Projection Development Regulation Of Water Loss Via Skin Cell Junction Assembly Adherens Junction Organization Response To Drug Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Regulation Of Immune Response Protein Homooligomerization Intestinal Epithelial Cell Development Salivary Gland Cavitation Regulation Of Branching Involved In Salivary Gland Morphogenesis Tight Junction Assembly Cellular Response To Amino Acid Stimulus Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Development Regulation Of Protein Localization To Cell Surface Regulation Of Neuron Migration
Pathways		Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway	Cell junction organization Apoptotic cleavage of cellular proteins Adherens junctions interactions Apoptotic execution phase Degradation of the extracellular matrix Apoptotic cleavage of cell adhesion proteins Cell-cell junction organization Programmed Cell Death Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS			Colorectal cancer ( 19011631) Ulcerative colitis ( 19915572)
Protein-Protein Interactions		45 interactors: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNBIP1 CTNND1 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 FER FHL2 FYN MUC1 NFATC4 NFKBIE PECAM1 PKD1 PKP2 PKP3 PSEN1 PTPN14 PTPRF PTPRJ PTPRK RIBC2 SRC TCF4 TCF7L2 WDYHV1 ZFYVE9	55 interactors: ACTR3 ANAPC1 ANAPC11 ANAPC4 ANAPC7 ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC16 CDC23 CDC26 CDC42 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBB2IP EZR FER FYN GNA12 GNA13 GSK3B HDAC1 HDAC2 IQGAP1 IRS1 ITGAE ITGB7 JUP MAD2L2 MDM2 NDRG1 NEDD9 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SKP2 TACC3 UCHL3 VCL YES1
Entrez ID		3728	999
HPRD ID		01414	01885
Ensembl ID		ENSG00000173801	ENSG00000039068
Uniprot IDs		P14923	P12830 Q9UII8
PDB IDs		3IFQ	1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Cell-cell Junction Organization Adherens Junction Organization Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Cellular Component Movement Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Signaling Anatomical Structure Development Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cell Proliferation Regulation Of Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Anatomical Structure Morphogenesis Developmental Process Multicellular Organismal Development System Development Execution Phase Of Apoptosis Cardiovascular System Development Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Ventricular Cardiac Muscle Cell Action Potential Response To Organic Substance Response To Stress Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cell Motility Negative Regulation Of Cell Death Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Organ Morphogenesis Organ Development Cellular Component Assembly Regulation Of Locomotion Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cellular Component Organization Signal Transduction Regulation Of Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stress Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction	Single Organismal Cell-cell Adhesion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Adhesion Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Mitotic Spindle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Chromosome Segregation Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Anatomical Structure Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Positive Regulation Of Proteolysis Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Negative Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Catabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?