JUP and CTNNA1

Number of citations of the paper that reports this interaction (PMID 7890674)
59

Data Source:
HPRD (in vitro, in vivo)

		JUP	CTNNA1
Gene Name		junction plakoglobin	catenin (cadherin-associated protein), alpha 1, 102kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Extracellular Vesicular Exosome Gamma-catenin-TCF7L2 Complex	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Lamellipodium
	Molecular Function	Transcription Coactivator Activity Signal Transducer Activity Structural Molecule Activity Structural Constituent Of Cell Wall Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding	Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Poly(A) RNA Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Desmosome Assembly Cytoskeletal Anchoring At Plasma Membrane Single Organismal Cell-cell Adhesion Cell Migration Cell Junction Assembly Adherens Junction Organization Adherens Junction Assembly Regulation Of Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Regulation Of Cell Fate Specification Skin Development Cell-cell Junction Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Mechanical Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Heterooligomerization Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Canonical Wnt Signaling Pathway	Ovarian Follicle Development Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Axon Regeneration Cell Junction Assembly Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Muscle Cell Differentiation Apical Junction Assembly Response To Estrogen Cell-cell Junction Organization Positive Regulation Of Smoothened Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway	Cell junction organization Cell-cell junction organization CDO in myogenesis Myogenesis Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNBIP1 CTNND1 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 FER FHL2 FYN MUC1 NFATC4 NFKBIE PECAM1 PKD1 PKP2 PKP3 PSEN1 PTPN14 PTPRF PTPRJ PTPRK RIBC2 SRC TCF4 TCF7L2 WDYHV1 ZFYVE9	27 interactors: ACTN1 AJUBA APC APP ARMC8 CA9 CDH1 CDH15 CDH2 CDH3 CDH5 CTBP1 CTNNB1 DLG1 FAM84B JUP MLLT4 PKD1 PSEN1 RNF219 SPTAN1 SPTBN1 SUMO1 TJP1 TJP2 VCL ZGPAT
Entrez ID		3728	1495
HPRD ID		01414	00285
Ensembl ID		ENSG00000173801	ENSG00000044115
Uniprot IDs		P14923	P35221
PDB IDs		3IFQ	1H6G 4EHP 4IGG
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Cell-cell Junction Organization Adherens Junction Organization Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Cellular Component Movement Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Signaling Anatomical Structure Development Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cell Proliferation Regulation Of Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Anatomical Structure Morphogenesis Developmental Process Multicellular Organismal Development System Development Execution Phase Of Apoptosis Cardiovascular System Development Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Ventricular Cardiac Muscle Cell Action Potential Response To Organic Substance Response To Stress Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cell Motility Negative Regulation Of Cell Death Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Organ Morphogenesis Organ Development Cellular Component Assembly Regulation Of Locomotion Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cellular Component Organization Signal Transduction Regulation Of Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stress Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction	Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Cell Adhesion Cellular Component Assembly Epithelium Development Developmental Process Anatomical Structure Development Cell-cell Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Single Organismal Cell-cell Adhesion Execution Phase Of Apoptosis Adherens Junction Assembly Cell Differentiation Tissue Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Development Cellular Response To Indole-3-methanol Establishment Of Endothelial Barrier Apical Junction Assembly Anatomical Structure Morphogenesis Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Complex Assembly Regulation Of Cellular Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Skin Development Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Endothelial Cell Development Tight Junction Assembly Positive Regulation Of Protein Metabolic Process Locomotion Endomembrane System Organization Neurogenesis Apoptotic Process Regulation Of Epithelial Cell Proliferation Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Programmed Cell Death Morphogenesis Of An Epithelium Cell Death Death Cell-matrix Adhesion Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Endothelial Cell Differentiation Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Intersection) ?