JUP and PTPRK

Number of citations of the paper that reports this interaction (PubMedID 8663237)
0

Data Source:
HPRD (in vitro, in vivo)

		JUP	PTPRK
Description		junction plakoglobin	protein tyrosine phosphatase receptor type K
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GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Anchoring Junction Catenin-TCF7L2 Complex Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen	Plasma Membrane Cell-cell Junction Adherens Junction Cell Surface Membrane Cell Junction Leading Edge Membrane Anchoring Junction
	Molecular Function	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Nuclear Receptor Binding Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Hydrolase Activity Protein Kinase Binding Gamma-catenin Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Adhesion Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Canonical Wnt Signaling Pathway Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Protein Dephosphorylation Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Migration Negative Regulation Of Cell Migration Neuron Projection Development Protein Localization To Cell Surface Cellular Response To Reactive Oxygen Species Cellular Response To UV Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Focal Adhesion Assembly
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CDH11 homotypic and heterotypic interactions	EGFR downregulation
Drugs		Zinc Zinc acetate
Diseases		Naxos disease and Carvajal syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Heel bone mineral density ( 28869591 30598549) Major depressive disorder x sex interaction ( 34099189)	Adiponectin levels ( 33562295) Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 31959851 31619474 31361310 30929738 32296059 34103634) Asthma (childhood onset) ( 30929738) Celiac disease ( 30572963 22057235 20190752) Crohn's disease ( 28067908) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Hodgkin's lymphoma ( 29196614) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Multiple sclerosis ( 21833088) Nodular sclerosis Hodgkin lymphoma ( 29196614) Reaction time ( 29844566) Uterine fibroid size (maximum volume) ( 30196971) Waist circumference ( 28552196)
Interacting Genes		55 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HDAC1 HDAC2 HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9	9 interacting genes: CSNK2B CTNNB1 GADD45A GADD45G JUP PSMD11 PTPRM RIPK4 TK1
Entrez ID		3728	5796
HPRD ID		01414	03968
Ensembl ID		ENSG00000173801	ENSG00000152894
Uniprot IDs		A0A0S2Z487 P14923	B4DHC3 Q15262 Q59EZ1 Q86WJ2
PDB IDs		3IFQ	2C7S 8A1F
Enriched GO Terms of Interacting Partners?		Beta-catenin Binding Desmosome Cell Junction Cell-cell Adhesion Gamma-catenin Binding Cell Junction Organization Anchoring Junction Cell Adhesion Cell-cell Junction Organization Adherens Junction Cell-cell Junction Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Junction Assembly Cadherin Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Catenin Complex Cornified Envelope Anatomical Structure Morphogenesis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cell Migration Cell Motility Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Positive Regulation Of Protein Localization Regulation Of Protein Localization To Cell-cell Junction Developmental Process Lateral Plasma Membrane Cell Surface Receptor Signaling Pathway Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Intracellular Signal Transduction Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Apoptotic Process Plasma Membrane Intercalated Disc	Negative Regulation Of Endothelial Cell Migration Catenin-TCF7L2 Complex Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Indole-3-methanol Skin Development Response To Indole-3-methanol Negative Regulation Of Cell Migration Endothelial Tube Morphogenesis Regulation Of Vasculature Development Alpha-catenin Binding Regulation Of Angiogenesis Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Blood Vessel Endothelial Cell Migration Ficolin-1-rich Granule Lumen Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of P38MAPK Cascade Catenin Complex Adherens Junction Response To Mechanical Stimulus Cell-cell Junction Regulation Of P38MAPK Cascade Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Intercalated Disc Wnt Signaling Pathway Cytoplasm Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Cadherin Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Gamma-catenin-TCF7L2 Complex Morphogenesis Of An Epithelium Positive Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tissue Morphogenesis Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development
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