JUP and PTPRK

Number of citations of the paper that reports this interaction (PMID 8663237)
31

Data Source:
HPRD (in vitro, in vivo)

		JUP	PTPRK
Gene Name		junction plakoglobin	protein tyrosine phosphatase, receptor type, K
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Extracellular Vesicular Exosome Gamma-catenin-TCF7L2 Complex	Photoreceptor Outer Segment Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Cell Surface Integral Component Of Membrane Axon Dendrite Leading Edge Membrane Neuronal Cell Body
	Molecular Function	Transcription Coactivator Activity Signal Transducer Activity Structural Molecule Activity Structural Constituent Of Cell Wall Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Gamma-catenin Binding
	Biological Process	Desmosome Assembly Cytoskeletal Anchoring At Plasma Membrane Single Organismal Cell-cell Adhesion Cell Migration Cell Junction Assembly Adherens Junction Organization Adherens Junction Assembly Regulation Of Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Regulation Of Cell Fate Specification Skin Development Cell-cell Junction Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Mechanical Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Heterooligomerization Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Dephosphorylation Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Migration Negative Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Reactive Oxygen Species Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Focal Adhesion Assembly
Pathways		Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		45 interactors: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNBIP1 CTNND1 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 FER FHL2 FYN MUC1 NFATC4 NFKBIE PECAM1 PKD1 PKP2 PKP3 PSEN1 PTPN14 PTPRF PTPRJ PTPRK RIBC2 SRC TCF4 TCF7L2 WDYHV1 ZFYVE9	8 interactors: CSNK2B CTNNB1 GADD45A GADD45G JUP PSMD11 PTPRM TK1
Entrez ID		3728	5796
HPRD ID		01414	03968
Ensembl ID		ENSG00000173801	ENSG00000152894
Uniprot IDs		P14923	B4DHC3 B7ZMG0 Q15262 Q59EZ1 Q5TG12 Q86WJ2
PDB IDs		3IFQ	2C7S
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Cell-cell Junction Organization Adherens Junction Organization Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Cellular Component Movement Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Signaling Anatomical Structure Development Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cell Proliferation Regulation Of Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Anatomical Structure Morphogenesis Developmental Process Multicellular Organismal Development System Development Execution Phase Of Apoptosis Cardiovascular System Development Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Ventricular Cardiac Muscle Cell Action Potential Response To Organic Substance Response To Stress Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cell Motility Negative Regulation Of Cell Death Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Organ Morphogenesis Organ Development Cellular Component Assembly Regulation Of Locomotion Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cellular Component Organization Signal Transduction Regulation Of Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stress Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction	Positive Regulation Of Signal Transduction Cellular Response To Indole-3-methanol Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Protein Modification Process Response To External Stimulus Endothelial Tube Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Protein Complex Assembly Regulation Of P38MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Fate Specification Positive Regulation Of Protein Metabolic Process Response To Mechanical Stimulus Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Fate Commitment Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Adherens Junction Assembly Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Negative Regulation Of Transferase Activity Regulation Of Signaling Regulation Of Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Cellular Component Assembly Centrosome Cycle Apoptotic Process Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Response To Stimulus Developmental Process Cell Death Cellular Response To Mechanical Stimulus Death Regulation Of Protein Metabolic Process Protein Oligomerization Adherens Junction Organization Positive Regulation Of MAPK Cascade Fetal Process Involved In Parturition Negative Regulation Of Cell Cycle Endothelium Development Signal Transduction In Response To DNA Damage Locomotion Centrosome Organization Regulation Of Phosphorylation Regulation Of Endothelial Cell Migration
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jag1 jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jag1 jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby
Tagcloud (Intersection) ?