JUP and NTAQ1

Number of citations of the paper that reports this interaction (PubMedID 19060904)
32

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		JUP	NTAQ1
Description		junction plakoglobin	N-terminal glutamine amidase 1
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Anchoring Junction Catenin-TCF7L2 Complex Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Nuclear Receptor Binding Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity	Protein Binding Protein-N-terminal Asparagine Amidohydrolase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Protein-N-terminal Glutamine Amidohydrolase Activity
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Adhesion Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Canonical Wnt Signaling Pathway Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Protein Modification Process
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CDH11 homotypic and heterotypic interactions
Drugs		Zinc Zinc acetate
Diseases		Naxos disease and Carvajal syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Heel bone mineral density ( 28869591 30598549) Major depressive disorder x sex interaction ( 34099189)
Interacting Genes		55 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HDAC1 HDAC2 HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9	379 interacting genes: - AARD ACD ACOT13 ACTB ACTG1 ACTN2 ACY1 ADAMTSL4 AGR2 AGR3 AIMP2 AKIRIN2 AMOT AMOTL2 AMPD2 ANKRD11 ANKRD36B AOC1 APIP ARID4B ARL6IP1 ASL ATP6V1G1 BANF2 BCL2L2-PABPN1 BEND5 BIRC7 BLMH BLOC1S6 BLZF1 BOLA2 BOLA2B BORCS6 BPIFB3 BTBD2 BTBD6 C1orf50 CAMK2A CAPN3 CARD9 CASP6 CAVIN4 CBFA2T2 CBS CBY2 CCDC102B CCDC152 CCDC184 CCDC197 CCHCR1 CCNB1IP1 CD22 CDA CDCA8 CDK2AP1 CDKN2AIPNL CDR2 CENPP CEP170B CEP55 CEP70 CEP85 CGGBP1 CHCHD3 CHMP4A CMTM5 COG6 COIL CRYAA CSNK2B CT45A1 CTAG1A CTAG1B CTBP1 CTH CUEDC1 CUTC CYSRT1 DAB1 DCTPP1 DEUP1 DHPS DNAL4 DNM2 DYNLT1 EDARADD EGLN3 EIF2B1 EIF4G1 EMILIN3 ENOX2 EP400 EPN3 ETV6 EXOSC8 FAM136A FAM72A FAM72D FKBP6 FTH1 FTL GADD45GIP1 GAS7 GCSAML GFAP GMCL1 GMDS GNG3 GNMT GNPDA2 GOLGA2 GOLGA6L9 GPX7 GRAMD4 GSTA4 GSTO2 GTF2H2C H2AP HAUS8 HBQ1 HBZ HEATR5A HGD HIGD1C HMG20A HOMER3 HOXB6 HPRT1 HSD17B14 HSF2BP HSPE1 HUS1 IKZF3 IL16 IL31 INCA1 ISCA2 ITGB3BP JAKMIP2 JUP KASH5 KATNBL1 KCNH1 KCTD1 KCTD10 KCTD13 KCTD15 KCTD21 KCTD4 KCTD6 KCTD7 KCTD9 KEAP1 KIF21B KLHL12 KLHL2 KLHL20 KRT27 KRT31 KRTAP10-5 KRTAP10-7 KRTAP19-2 KRTAP19-6 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-9 KRTAP6-1 KRTAP9-2 KRTAP9-4 KRTAP9-8 L3MBTL3 LCE1C LCE1D LCE1E LCE1F LCE2C LCE5A LDB2 LENG1 LGALS2 LGALS9B LIN7B LMNA LMO1 LMO2 LMO3 LNX2 LONRF1 LRIF1 LRRC73 LSM12 LSM14B LZTFL1 LZTS1 LZTS2 MAB21L3 MAD1L1 MAGEA11 MAGEA12 MAGEA2 MAGEA2B MALSU1 MARCHF10 MATN4 MDFI MED22 MIF MIF4GD MIOS MIPOL1 MIS18A MITD1 MOB2 MORN3 MPLKIP MRFAP1L1 MRPL12 MTHFD2L MTUS2 MVP MXRA8 MYD88 N4BP3 NAB2 NADSYN1 NAGK NCOA5 NDUFAB1 NECAB2 NME1 NPL NR5A1 NT5C1A NTAN1 NUDT14 NUDT16L1 NUDT21 OOEP PAK5 PCBD1 PFDN5 PGPEP1 PIH1D2 PLA2G10 PLCD1 PLEKHB2 PLEKHJ1 PNMA1 PNMA2 PNMA5 POLR2J POMC PPCDC PPM1K PPP1R27 PRKAR1B PRMT1 PRMT5 PRPS2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23B PRTFDC1 PSMB5 PSME3 PTS PYCR3 PYGM RAB42 RABAC1 RASAL3 RBBP8 RBM20 RBM45 RBM48 RBPMS RD3 REEP6 RHOQ RILPL1 RNF138 RNF4 ROPN1 RPIA RUSC1 S100A11 SAP18 SARS2 SAT1 SCARA5 SELENOV SEPTIN14 SEPTIN3 SFN SH3GLB2 SIAH1 SIKE1 SIVA1 SLAIN1 SLC15A2 SLPI SMAP1 SMN1 SNAP29 SNRPD3 SPANXB1 SPATA32 SPDYE4 SPINDOC SPRYD7 SSNA1 SSX2IP STH STMN2 STN1 STX11 SYCE1L SYNGAP1 TAX1BP1 TBX15 TCL1A TCP10L TEKT1 TEPSIN THAP1 THAP6 THAP7 THG1L TICAM2 TIFA TLE5 TMEM239 TNFAIP1 TNIP3 TNR TOLLIP TRAF1 TRAF3 TRAF5 TRIM23 TRIM27 TRIM32 TRIM5 TRIM54 TRIM69 TRIM73 TRIM9 TRIP13 TSC22D1 TSN TSNAX UBR1 UBR2 UFC1 UNKL VAC14 VCP VDR VMA22 VPS37C VXN XIAP ZBED1 ZBTB8A ZBTB8B ZC2HC1C ZCCHC17 ZNF165 ZNF341 ZNF436 ZNF511 ZNF618 ZSCAN16 ZSCAN32
Entrez ID		3728	55093
HPRD ID		01414	07653
Ensembl ID		ENSG00000173801	ENSG00000156795
Uniprot IDs		A0A0S2Z487 P14923	E5RHC2 Q96HA8
PDB IDs		3IFQ	3C9Q 4W79 6KGJ 8JJF 8JJG 8JJH 8JJI 8JJU 8JJW 8JJX 8JJY 8JJZ 8JK0 8JK1 8JK2
Enriched GO Terms of Interacting Partners?		Beta-catenin Binding Desmosome Cell Junction Cell-cell Adhesion Gamma-catenin Binding Cell Junction Organization Anchoring Junction Cell Adhesion Cell-cell Junction Organization Adherens Junction Cell-cell Junction Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Junction Assembly Cadherin Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Catenin Complex Cornified Envelope Anatomical Structure Morphogenesis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cell Migration Cell Motility Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Positive Regulation Of Protein Localization Regulation Of Protein Localization To Cell-cell Junction Developmental Process Lateral Plasma Membrane Cell Surface Receptor Signaling Pathway Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Intracellular Signal Transduction Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Apoptotic Process Plasma Membrane Intercalated Disc	Identical Protein Binding Protein Binding Cytosol Protein Homooligomerization Protein Complex Oligomerization Cytoplasm Intermediate Filament Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Protein Sumoylation Keratin Filament Sulfur Amino Acid Metabolic Process Regulation Of Protein Sumoylation Protein-containing Complex Assembly Keratinization Ubiquitin-protein Transferase Activity N-acetylneuraminate Catabolic Process Protein Tetramerization Purine Nucleoside Metabolic Process Amino Acid Metabolic Process Cul3-RING Ubiquitin Ligase Complex
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