JUP and CDH10

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		JUP	CDH10
Gene Name		junction plakoglobin	cadherin 10, type 2 (T2-cadherin)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Extracellular Vesicular Exosome Gamma-catenin-TCF7L2 Complex	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coactivator Activity Signal Transducer Activity Structural Molecule Activity Structural Constituent Of Cell Wall Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding	Calcium Ion Binding
	Biological Process	Desmosome Assembly Cytoskeletal Anchoring At Plasma Membrane Single Organismal Cell-cell Adhesion Cell Migration Cell Junction Assembly Adherens Junction Organization Adherens Junction Assembly Regulation Of Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Regulation Of Cell Fate Specification Skin Development Cell-cell Junction Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Mechanical Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Heterooligomerization Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Canonical Wnt Signaling Pathway	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization
Pathways		Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway	Cell junction organization Cell-cell junction organization Adherens junctions interactions
Drugs
Diseases
GWAS			β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Autism ( 19404256)
Protein-Protein Interactions		45 interactors: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNBIP1 CTNND1 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 FER FHL2 FYN MUC1 NFATC4 NFKBIE PECAM1 PKD1 PKP2 PKP3 PSEN1 PTPN14 PTPRF PTPRJ PTPRK RIBC2 SRC TCF4 TCF7L2 WDYHV1 ZFYVE9	5 interactors: CDH6 CDH9 COPS6 JUP PTN
Entrez ID		3728	1008
HPRD ID		01414	05187
Ensembl ID		ENSG00000173801	ENSG00000040731
Uniprot IDs		P14923	Q9Y6N8
PDB IDs		3IFQ
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Cell-cell Junction Organization Adherens Junction Organization Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Cellular Component Movement Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Signaling Anatomical Structure Development Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cell Proliferation Regulation Of Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Anatomical Structure Morphogenesis Developmental Process Multicellular Organismal Development System Development Execution Phase Of Apoptosis Cardiovascular System Development Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Ventricular Cardiac Muscle Cell Action Potential Response To Organic Substance Response To Stress Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cell Motility Negative Regulation Of Cell Death Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Organ Morphogenesis Organ Development Cellular Component Assembly Regulation Of Locomotion Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cellular Component Organization Signal Transduction Regulation Of Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stress Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction	Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Endothelial Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Desmosome Assembly Cellular Response To Indole-3-methanol Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Adhesion Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Cullin Deneddylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cytoskeletal Anchoring At Plasma Membrane Protein Deneddylation Regulation Of Cell Fate Specification Ventricular Cardiac Muscle Cell Action Potential Cellular Component Assembly Single Organismal Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cell Fate Commitment Epithelial Cell-cell Adhesion Cardiac Muscle Cell Action Potential Adherens Junction Assembly Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Detection Of Mechanical Stimulus Bone Mineralization
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	apc atlas capture characterisation col6a3 crc devised dock2 exome fat4 genomes kras mutated nevertheless next predicts prognostication recurrently sequencing signature silent smad4 somatic staging stratifying tmem132d tnm vcan verified
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	apc atlas capture characterisation col6a3 crc devised dock2 exome fat4 genomes kras mutated nevertheless next predicts prognostication recurrently sequencing signature silent smad4 somatic staging stratifying tmem132d tnm vcan verified
Tagcloud (Intersection) ?