JUP and CDH10

Number of citations: 69 (PubMedID 24722188)
Data Source: BioGRID (two hybrid)

		JUP	CDH10
Name		junction plakoglobin	cadherin 10
Structure			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Anchoring Junction Catenin-TCF7L2 Complex Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen	Plasma Membrane Adherens Junction Membrane Catenin Complex Synapse Presynaptic Active Zone Membrane Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Nuclear Receptor Binding Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Adhesion Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Canonical Wnt Signaling Pathway Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Cell-cell Adhesion Synaptic Membrane Adhesion
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CDH11 homotypic and heterotypic interactions	Adherens junctions interactions
Drugs		Zinc Zinc acetate	None
Diseases		Naxos disease and Carvajal syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC)	None
GWAS		Heel bone mineral density ( 28869591 30598549 ) Major depressive disorder x sex interaction ( 34099189 )	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374 ) Anorexia nervosa ( 31308545 ) Autism ( 19404256 ) General risk tolerance (MTAG) ( 30643258 ) HDL cholesterol levels in HIV infection ( 33109212 ) Hepcidin/ferritin ratio ( 27846281 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Obsessive-compulsive disorder ( 24821223 ) Polycystic ovary syndrome (reproductive subtype) ( 32574161 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971 )
Interacting Genes		55 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HDAC1 HDAC2 HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9	5 interacting genes: CDH6 CDH9 COPS6 JUP PTN
Entrez ID		3728	1008
HPRD ID		01414	05187
Ensembl ID		ENSG00000173801	ENSG00000040731
Uniprot IDs		A0A0S2Z487 P14923	Q9Y6N8 X5D8X5 X5DNG6
PDB IDs		3IFQ	Not available
GO Terms Enriched among Interactors		Beta-catenin Binding Desmosome Cell Junction Cell-cell Adhesion Gamma-catenin Binding Cell Junction Organization Anchoring Junction Cell Adhesion Cell-cell Junction Organization Adherens Junction Cell-cell Junction Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Junction Assembly Cadherin Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Catenin Complex Cornified Envelope Anatomical Structure Morphogenesis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cell Migration Cell Motility Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Positive Regulation Of Protein Localization Regulation Of Protein Localization To Cell-cell Junction Developmental Process Lateral Plasma Membrane Cell Surface Receptor Signaling Pathway Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Intracellular Signal Transduction Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Apoptotic Process Plasma Membrane Intercalated Disc	Catenin Complex Cell-cell Junction Assembly Cell-cell Junction Organization Adherens Junction Synaptic Membrane Adhesion Cell Junction Assembly Cell Migration Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cadherin Binding Cell Motility Adherens Junction Organization Cell Junction Organization Cell-cell Adhesion Gamma-catenin-TCF7L2 Complex Beta-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Dendrite Regeneration Catenin-TCF7L2 Complex Ossification Involved In Bone Remodeling Cell Morphogenesis Cell Adhesion Cytoskeletal Protein-membrane Anchor Activity Endothelial Cell-cell Adhesion Regulation Of Endothelial Cell Migration Response To Mechanical Stimulus Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cellular Response To Indole-3-methanol Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Response To Indole-3-methanol Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Hemidesmosome Zonula Adherens Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Axon Regeneration Alpha-catenin Binding Chondroitin Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Protein Localization To Membrane Estrous Cycle Protein Deneddylation Regulation Of Ventricular Cardiac Muscle Cell Action Potential Dendrite Arborization Negative Regulation Of Long-term Synaptic Potentiation Metal-dependent Deubiquitinase Activity Negative Regulation Of Neuroblast Proliferation Desmosome Organization