JUP and PTPRJ

Number of citations of the paper that reports this interaction (PubMedID 12370829)
0

Data Source:
HPRD (in vitro)

		JUP	PTPRJ
Description		junction plakoglobin	protein tyrosine phosphatase receptor type J
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Anchoring Junction Catenin-TCF7L2 Complex Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen	Immunological Synapse Extracellular Region Nucleoplasm Nucleolus Plasma Membrane Cell-cell Junction Cell Surface Membrane Nuclear Body Cell Junction Ruffle Membrane Specific Granule Membrane Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Nuclear Receptor Binding Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Adhesion Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Canonical Wnt Signaling Pathway Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Angiogenesis Vasculogenesis Positive Regulation Of Cell-matrix Adhesion Immune System Process Signal Transduction Axon Guidance Heart Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Platelet Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Cytokine-mediated Signaling Pathway Hemopoiesis Regulation Of Cell Adhesion B Cell Differentiation Platelet Formation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Glucose Homeostasis Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Negative Regulation Of Insulin Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Cellular Component Organization Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Contact Inhibition Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CDH11 homotypic and heterotypic interactions	Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3
Drugs		Zinc Zinc acetate
Diseases		Naxos disease and Carvajal syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Heel bone mineral density ( 28869591 30598549) Major depressive disorder x sex interaction ( 34099189)	Acute lymphoblastic leukemia (childhood) ( 22076464) Alanine aminotransferase levels ( 33547301) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Caffeine consumption from coffee or tea ( 33287642) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31879980) Intraocular pressure ( 31798171 31959993 30054594 29785010 29617998 29235454 25173106) Kawasaki disease ( 33692975) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 33838163) Sleep duration (short sleep) ( 30846698)
Interacting Genes		55 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HDAC1 HDAC2 HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9	37 interacting genes: ANP32B BAAT BAP1 CASC3 CNKSR1 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 FANCC FBP1 HEMGN HOXC6 HRAS IL2RG JUP KLK7 KLK9 LAT LYPD3 MAP2K1 MET NANS NOP2 PDGFRB PLCG1 PPP2CB PPP3R2 PRDM14 RASA1 SDCBP SFRP4 TMEFF1 TRMO TSTD2 ZNF510
Entrez ID		3728	5795
HPRD ID		01414	02955
Ensembl ID		ENSG00000173801	ENSG00000149177
Uniprot IDs		A0A0S2Z487 P14923	Q12913 Q9NPR5
PDB IDs		3IFQ	2CFV 2DLE 2NZ6 7U01 7U08
Enriched GO Terms of Interacting Partners?		Beta-catenin Binding Desmosome Cell Junction Cell-cell Adhesion Gamma-catenin Binding Cell Junction Organization Anchoring Junction Cell Adhesion Cell-cell Junction Organization Adherens Junction Cell-cell Junction Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Junction Assembly Cadherin Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Catenin Complex Cornified Envelope Anatomical Structure Morphogenesis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cell Migration Cell Motility Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Positive Regulation Of Protein Localization Regulation Of Protein Localization To Cell-cell Junction Developmental Process Lateral Plasma Membrane Cell Surface Receptor Signaling Pathway Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Intracellular Signal Transduction Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Apoptotic Process Plasma Membrane Intercalated Disc	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Catenin-TCF7L2 Complex Phospholipase C Activator Activity ERBB Signaling Pathway Cellular Response To Indole-3-methanol Positive Regulation Of MAPK Cascade Catenin Complex Cell Morphogenesis Protein Phosphatase Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Signal Transduction Response To Indole-3-methanol Cell-cell Junction Trachea Formation Regulation Of Blood Vessel Branching Regulation Of Calcium Ion Import Regulation Of Ras Protein Signal Transduction Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activity Alpha-catenin Binding Phosphatase Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphorylation Vasculature Development Regulation Of Cell Motility Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Transport Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Transport Intracellular Signaling Cassette Tube Morphogenesis Regulation Of MAPK Cascade Histone Methyltransferase Binding Regulation Of Cell Population Proliferation Ciliary Basal Body Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Adherens Junction
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