ITPR3 and BECN1

Number of citations of the paper that reports this interaction (PubMedID 22082873)
71

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ITPR3	BECN1
Description		inositol 1,4,5-trisphosphate receptor type 3	beclin 1
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GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Brush Border Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Apical Part Of Cell Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Phagophore Assembly Site Nucleus Cytoplasm Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Endosome Membrane Membrane Nuclear Body Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Protein-containing Complex Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle
	Molecular Function	Inositol Hexakisphosphate Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Intracellularly Gated Calcium Channel Activity Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding GTPase Binding Molecular Adaptor Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Calcium-mediated Signaling Platelet Activation Monoatomic Ion Transmembrane Transport Sensory Perception Of Taste Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Response To Calcium Ion Calcium Ion Homeostasis Transmembrane Transport Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport	Autophagosome Assembly Mitophagy Response To Hypoxia Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Targeting To Lysosome Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Mitotic Metaphase Chromosome Alignment JNK Cascade Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Iron(II) Ion Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Macroautophagy Regulation Of Macroautophagy Response To Nutrient Levels Regulation Of Cytokinesis Receptor Catabolic Process Response To Vitamin E Cellular Response To Amino Acid Starvation Phosphatidylinositol-3-phosphate Biosynthetic Process P38MAPK Cascade Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Engulfment Of Apoptotic Cell Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Neuron Development Amyloid-beta Metabolic Process Cell Division Defense Response To Virus Response To Other Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Aluminum Ion Cellular Response To Copper Ion Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Autophagosome Assembly Negative Regulation Of Lysosome Organization Positive Regulation Of Autophagosome Assembly Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Sensory perception of sweet, bitter, and umami (glutamate) taste Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	ISG15 antiviral mechanism Macroautophagy Ub-specific processing proteases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC RSV-host interactions
Drugs		Caffeine	Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma and attention deficit hyperactivity disorder ( 31619474) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 23850713) Educational attainment ( 23722424) Hodgkin's lymphoma ( 30194254) Multiple sclerosis and body mass index (pleiotropy) ( 26920376) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539) Regular attendance at a gym or sports club ( 29970889) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		18 interacting genes: AKT1 ANK1 BAP1 BECN1 CABP1 ITPR1 MTDH MTNR1A MTNR1B SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	61 interacting genes: AKT1 AMBRA1 ARAF ARNT BCL2 BCL2L1 BCL2L10 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 HERC5 HSPB6 ITCH ITPR1 ITPR3 ITSN1 KAT2A KDELR2 KLHL20 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 MST1 NF2 NLRP6 NXF1 PDGFRA PGK1 RACK1 RAF1 RIPK2 SENP3 SHD SMAD2 STK11 STYK1 TEAD2 TERT TSC1 UBC ULK1 WASHC1 XPO1 YES1
Entrez ID		3710	8678
HPRD ID		00926	05087
Ensembl ID		ENSG00000096433	ENSG00000126581
Uniprot IDs		A6H8K3 Q14573 Q59ES2	A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4
PDB IDs		6DQJ 6DQN 6DQS 6DQV 6DQZ 6DR0 6DR2 6DRA 6DRC 6UQK 7T3P 7T3Q 7T3R 7T3T 7T3U 8TK8 8TKD 8TKE 8TKF 8TKG 8TKH 8TKI 8TL9 8TLA	2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK 7BL1 8SOR 9C82 9MHF 9MHG 9MHH
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Store-operated Calcium Channel Activity Cation Channel Complex Calcium Channel Activity Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Calcium Ion Transport Monoatomic Ion Channel Activity Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Homeostatic Process Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Chemical Homeostasis Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Cellular Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Transmembrane Transport Intracellular Chemical Homeostasis ATPase Binding Single Fertilization Monoatomic Cation Channel Activity Melatonin Receptor Activity Plasma Membrane Response To Calcium Ion Fertilization Response To Metal Ion Membrane Positive Regulation Of Monoatomic Ion Transport Intracellularly Gated Calcium Channel Activity Negative Regulation Of Dendrite Morphogenesis Cellular Response To Hydrogen Peroxide Calcium Import Into The Mitochondrion Manganese Ion Transport Actinin Binding Positive Regulation Of Calcium Ion Transport Response To Hydrogen Peroxide Mitochondrial Calcium Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Response To Decreased Oxygen Levels Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Sequestering Of Calcium Ion	Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Tyrosine Kinase Activity Protein Serine Kinase Activity Regulation Of Cell Population Proliferation ATP Binding Regulation Of Signal Transduction Signal Transduction Cellular Response To Stress Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Transferase Activity Cytoplasm Regulation Of Programmed Cell Death Protein Modification Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Nucleotide Binding Regulation Of Developmental Process Cell Population Proliferation Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Protein Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Negative Regulation Of Multicellular Organismal Process Regulation Of Epithelial Cell Proliferation
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