ITPR3 and BAP1

Number of citations of the paper that reports this interaction (PubMedID 28614305)
41

Data Source:
BioGRID (enzymatic study)

		ITPR3	BAP1
Description		inositol 1,4,5-trisphosphate receptor type 3	BRCA1 associated deubiquitinase 1
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GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Brush Border Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Apical Part Of Cell Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol PR-DUB Complex
	Molecular Function	Inositol Hexakisphosphate Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Intracellularly Gated Calcium Channel Activity Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Chromatin Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Chromatin DNA Binding Histone H2A Deubiquitinase Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Calcium-mediated Signaling Platelet Activation Monoatomic Ion Transmembrane Transport Sensory Perception Of Taste Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Response To Calcium Ion Calcium Ion Homeostasis Transmembrane Transport Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport	Mitotic Cell Cycle Regulation Of Cell Growth In Utero Embryonic Development Tissue Homeostasis Thrombocyte Differentiation Chromatin Organization Proteolysis Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Protein Deubiquitination Cell Differentiation Erythrocyte Differentiation Neutrophil Differentiation Granulocyte Differentiation Heterochromatin Formation Myeloid Cell Apoptotic Process Monoubiquitinated Protein Deubiquitination Common Myeloid Progenitor Cell Proliferation Protein Modification Process Platelet Morphogenesis Erythrocyte Maturation Nucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Regulation Of Cell Cycle Hematopoietic Stem Cell Homeostasis Macrophage Homeostasis Neuron Cellular Homeostasis Leukocyte Proliferation Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Sensory perception of sweet, bitter, and umami (glutamate) taste Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs		Caffeine
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma and attention deficit hyperactivity disorder ( 31619474) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 23850713) Educational attainment ( 23722424) Hodgkin's lymphoma ( 30194254) Multiple sclerosis and body mass index (pleiotropy) ( 26920376) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539) Regular attendance at a gym or sports club ( 29970889) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		18 interacting genes: AKT1 ANK1 BAP1 BECN1 CABP1 ITPR1 MTDH MTNR1A MTNR1B SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	30 interacting genes: ASXL1 BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 H2BC3 HIF1A IGF1R ITPR3 LINC00598 MAP3K1 NBN PTPRJ RB1CC1 STK11 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1
Entrez ID		3710	8314
HPRD ID		00926	04366
Ensembl ID		ENSG00000096433	ENSG00000163930
Uniprot IDs		A6H8K3 Q14573 Q59ES2	F8W6N3 Q92560
PDB IDs		6DQJ 6DQN 6DQS 6DQV 6DQZ 6DR0 6DR2 6DRA 6DRC 6UQK 7T3P 7T3Q 7T3R 7T3T 7T3U 8TK8 8TKD 8TKE 8TKF 8TKG 8TKH 8TKI 8TL9 8TLA	7VPW 8H1T 8SVF
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Store-operated Calcium Channel Activity Cation Channel Complex Calcium Channel Activity Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Calcium Ion Transport Monoatomic Ion Channel Activity Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Homeostatic Process Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Chemical Homeostasis Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Cellular Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Transmembrane Transport Intracellular Chemical Homeostasis ATPase Binding Single Fertilization Monoatomic Cation Channel Activity Melatonin Receptor Activity Plasma Membrane Response To Calcium Ion Fertilization Response To Metal Ion Membrane Positive Regulation Of Monoatomic Ion Transport Intracellularly Gated Calcium Channel Activity Negative Regulation Of Dendrite Morphogenesis Cellular Response To Hydrogen Peroxide Calcium Import Into The Mitochondrion Manganese Ion Transport Actinin Binding Positive Regulation Of Calcium Ion Transport Response To Hydrogen Peroxide Mitochondrial Calcium Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Response To Decreased Oxygen Levels Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Sequestering Of Calcium Ion	Chromatin Remodeling Chromatin Organization Protein Modification Process Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Nucleus Protein Metabolic Process Telomere Maintenance Via Telomere Trimming Nuclear Body Cysteine-type Peptidase Activity Heterochromatin Formation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleoplasm Epigenetic Regulation Of Gene Expression Macromolecule Metabolic Process Response To Radiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of MiRNA Transcription Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Apoptotic Signaling Pathway Response To Light Stimulus Chromosome Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Deubiquitination Regulation Of Cell Communication Regulation Of Signaling Telomere Maintenance Negative Regulation Of Metabolic Process BRCA1-C Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Localization To Chromosome Negative Regulation Of Growth Double-strand Break Repair Protein Modification By Small Protein Removal Nucleosome DNA Damage Response Telomere Organization Ubiquitin-modified Histone Reader Activity Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Repair Recombinational Repair Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction
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