BECN1 and HSPB6

Number of citations of the paper that reports this interaction (PubMedID 29157081)
50

Data Source:
BioGRID (pull down)

		BECN1	HSPB6
Description		beclin 1	heat shock protein family B (small) member 6
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleus Cytoplasm Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Endosome Membrane Membrane Nuclear Body Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Protein-containing Complex Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding GTPase Binding Molecular Adaptor Activity	Structural Constituent Of Eye Lens Protein Kinase Binding Protein Homodimerization Activity Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Autophagosome Assembly Mitophagy Response To Hypoxia Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Targeting To Lysosome Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Mitotic Metaphase Chromosome Alignment JNK Cascade Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Iron(II) Ion Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Macroautophagy Regulation Of Macroautophagy Response To Nutrient Levels Regulation Of Cytokinesis Receptor Catabolic Process Response To Vitamin E Cellular Response To Amino Acid Starvation Phosphatidylinositol-3-phosphate Biosynthetic Process P38MAPK Cascade Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Engulfment Of Apoptotic Cell Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Neuron Development Amyloid-beta Metabolic Process Cell Division Defense Response To Virus Response To Other Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Aluminum Ion Cellular Response To Copper Ion Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Autophagosome Assembly Negative Regulation Of Lysosome Organization Positive Regulation Of Autophagosome Assembly Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Folding Response To Heat Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis
Pathways		ISG15 antiviral mechanism Macroautophagy Ub-specific processing proteases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC RSV-host interactions
Drugs		Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS		Type 2 diabetes (age of onset) ( 28060188)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		61 interacting genes: AKT1 AMBRA1 ARAF ARNT BCL2 BCL2L1 BCL2L10 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 HERC5 HSPB6 ITCH ITPR1 ITPR3 ITSN1 KAT2A KDELR2 KLHL20 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 MST1 NF2 NLRP6 NXF1 PDGFRA PGK1 RACK1 RAF1 RIPK2 SENP3 SHD SMAD2 STK11 STYK1 TEAD2 TERT TSC1 UBC ULK1 WASHC1 XPO1 YES1	6 interacting genes: BECN1 CRYAB HSPB8 SNCA YWHAG YWHAZ
Entrez ID		8678	126393
HPRD ID		05087	08130
Ensembl ID		ENSG00000126581	ENSG00000004776
Uniprot IDs		A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4	O14558 V9HWB6
PDB IDs		2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK 7BL1 8SOR 9C82 9MHF 9MHG 9MHH	4JUS 4JUT 5LTW 5LU1 5LU2 5LUM 5OK9 5OKF
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Tyrosine Kinase Activity Protein Serine Kinase Activity Regulation Of Cell Population Proliferation ATP Binding Regulation Of Signal Transduction Signal Transduction Cellular Response To Stress Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Transferase Activity Cytoplasm Regulation Of Programmed Cell Death Protein Modification Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Nucleotide Binding Regulation Of Developmental Process Cell Population Proliferation Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Protein Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Negative Regulation Of Multicellular Organismal Process Regulation Of Epithelial Cell Proliferation	Cellular Response To Stress Protein Sequestering Activity Cellular Response To Glucose Starvation Identical Protein Binding Response To Iron(II) Ion Regulation Of Protein Stability Regulation Of Lysosome Organization Cellular Response To Copper Ion Cellular Response To Starvation Protein Targeting Response To Stress Protein Domain Specific Binding Response To Starvation MAPK Cascade Response To Iron Ion Response To Copper Ion Cellular Response To Nutrient Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Oxidative Stress Regulation Of Autophagy Protein Localization To Lysosome Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling TORC1 Signaling Lysosome Organization Regulation Of Vacuole Organization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Organelle Localization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission TOR Signaling Cellular Response To Aluminum Ion Protein Localization To Vacuole Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Macroautophagy Response To Hydrogen Peroxide Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process
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