ITPR3 and TRPC7

Number of citations of the paper that reports this interaction (PubMedID 11290752)
56

Data Source:
BioGRID (pull down)

		ITPR3	TRPC7
Description		inositol 1,4,5-trisphosphate receptor type 3	transient receptor potential cation channel subfamily C member 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Brush Border Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Apical Part Of Cell Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Nucleus Nuclear Envelope Plasma Membrane Membrane Cation Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Inositol Hexakisphosphate Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Intracellularly Gated Calcium Channel Activity Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Calcium-mediated Signaling Platelet Activation Monoatomic Ion Transmembrane Transport Sensory Perception Of Taste Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Response To Calcium Ion Calcium Ion Homeostasis Transmembrane Transport Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport	Monoatomic Ion Transport Calcium Ion Transport Manganese Ion Transport Single Fertilization Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Sensory perception of sweet, bitter, and umami (glutamate) taste Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs		Caffeine
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma and attention deficit hyperactivity disorder ( 31619474) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 23850713) Educational attainment ( 23722424) Hodgkin's lymphoma ( 30194254) Multiple sclerosis and body mass index (pleiotropy) ( 26920376) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539) Regular attendance at a gym or sports club ( 29970889) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Body fat percentage ( 31752434) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) Interleukin-6 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Sleep duration (short sleep) ( 30846698)
Interacting Genes		18 interacting genes: AKT1 ANK1 BAP1 BECN1 CABP1 ITPR1 MTDH MTNR1A MTNR1B SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	4 interacting genes: ITPR3 MX1 TRPC3 TRPC6
Entrez ID		3710	57113
HPRD ID		00926	18228
Ensembl ID		ENSG00000096433	ENSG00000069018
Uniprot IDs		A6H8K3 Q14573 Q59ES2	Q70T25 Q9HCX4
PDB IDs		6DQJ 6DQN 6DQS 6DQV 6DQZ 6DR0 6DR2 6DRA 6DRC 6UQK 7T3P 7T3Q 7T3R 7T3T 7T3U 8TK8 8TKD 8TKE 8TKF 8TKG 8TKH 8TKI 8TL9 8TLA
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Store-operated Calcium Channel Activity Cation Channel Complex Calcium Channel Activity Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Calcium Ion Transport Monoatomic Ion Channel Activity Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Homeostatic Process Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Chemical Homeostasis Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Cellular Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Transmembrane Transport Intracellular Chemical Homeostasis ATPase Binding Single Fertilization Monoatomic Cation Channel Activity Melatonin Receptor Activity Plasma Membrane Response To Calcium Ion Fertilization Response To Metal Ion Membrane Positive Regulation Of Monoatomic Ion Transport Intracellularly Gated Calcium Channel Activity Negative Regulation Of Dendrite Morphogenesis Cellular Response To Hydrogen Peroxide Calcium Import Into The Mitochondrion Manganese Ion Transport Actinin Binding Positive Regulation Of Calcium Ion Transport Response To Hydrogen Peroxide Mitochondrial Calcium Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Response To Decreased Oxygen Levels Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Sequestering Of Calcium Ion	Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Store-operated Calcium Channel Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Monoatomic Ion Channel Activity Calcium Ion Transmembrane Transport Cation Channel Complex Calcium Ion Homeostasis Calcium Ion Transport Inorganic Ion Homeostasis Regulation Of Cytosolic Calcium Ion Concentration Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Calcium Ion Transport Single Fertilization Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Response To Calcium Ion Fertilization Chemical Homeostasis Monoatomic Ion Transport Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Inositol Hexakisphosphate Binding Intracellular Calcium Ion Homeostasis Positive Regulation Of Monoatomic Ion Transport Sensory Perception Of Umami Taste Sensory Perception Of Sweet Taste Regulation Of Calcium Ion Transport Transmembrane Transport Inositol 1,3,4,5 Tetrakisphosphate Binding Sensory Perception Of Bitter Taste Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Homeostatic Process Regulation Of Monoatomic Ion Transmembrane Transport Interleukin-27-mediated Signaling Pathway Slit Diaphragm Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Negative Regulation Of Dendrite Morphogenesis Response To Metal Ion Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Metal Ion Transport Calcium-activated Cation Channel Activity Response To Type I Interferon Positive Regulation Of Calcium Ion Transport Into Cytosol
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