BECN1 and SHD

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		BECN1	SHD
Description		beclin 1	Src homology 2 domain containing transforming protein D
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleus Cytoplasm Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Endosome Membrane Membrane Nuclear Body Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Protein-containing Complex Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding GTPase Binding Molecular Adaptor Activity	Phosphotyrosine Residue Binding Protein Binding
	Biological Process	Autophagosome Assembly Mitophagy Response To Hypoxia Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Targeting To Lysosome Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Mitotic Metaphase Chromosome Alignment JNK Cascade Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Iron(II) Ion Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Macroautophagy Regulation Of Macroautophagy Response To Nutrient Levels Regulation Of Cytokinesis Receptor Catabolic Process Response To Vitamin E Cellular Response To Amino Acid Starvation Phosphatidylinositol-3-phosphate Biosynthetic Process P38MAPK Cascade Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Engulfment Of Apoptotic Cell Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Neuron Development Amyloid-beta Metabolic Process Cell Division Defense Response To Virus Response To Other Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Aluminum Ion Cellular Response To Copper Ion Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Autophagosome Assembly Negative Regulation Of Lysosome Organization Positive Regulation Of Autophagosome Assembly Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ISG15 antiviral mechanism Macroautophagy Ub-specific processing proteases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC RSV-host interactions
Drugs		Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS		Type 2 diabetes (age of onset) ( 28060188)	Post-bronchodilator lung function in asthma (FVC) ( 32989782)
Interacting Genes		61 interacting genes: AKT1 AMBRA1 ARAF ARNT BCL2 BCL2L1 BCL2L10 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 HERC5 HSPB6 ITCH ITPR1 ITPR3 ITSN1 KAT2A KDELR2 KLHL20 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 MST1 NF2 NLRP6 NXF1 PDGFRA PGK1 RACK1 RAF1 RIPK2 SENP3 SHD SMAD2 STK11 STYK1 TEAD2 TERT TSC1 UBC ULK1 WASHC1 XPO1 YES1	14 interacting genes: ABL1 BECN1 CAPN10 EGFR ERBB2 ERBB3 ERBB4 KRTCAP2 MET MRPS22 NCK2 OLIG1 OSBPL6 PSG11
Entrez ID		8678	56961
HPRD ID		05087	15337
Ensembl ID		ENSG00000126581	ENSG00000105251
Uniprot IDs		A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4	Q96IW2
PDB IDs		2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK 7BL1 8SOR 9C82 9MHF 9MHG 9MHH
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Tyrosine Kinase Activity Protein Serine Kinase Activity Regulation Of Cell Population Proliferation ATP Binding Regulation Of Signal Transduction Signal Transduction Cellular Response To Stress Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Transferase Activity Cytoplasm Regulation Of Programmed Cell Death Protein Modification Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Nucleotide Binding Regulation Of Developmental Process Cell Population Proliferation Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Protein Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Negative Regulation Of Multicellular Organismal Process Regulation Of Epithelial Cell Proliferation	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB2 Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Neuron Differentiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Programmed Cell Death Receptor Complex ERBB3:ERBB2 Complex Protein Kinase Activity Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Apoptotic Process Kinase Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial Cell Proliferation ERBB2-EGFR Signaling Pathway Glial Cell Development Positive Regulation Of Cell Communication Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Negative Regulation Of Apoptotic Process Basolateral Plasma Membrane Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Animal Organ Development Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Endosome Membrane Protein Tyrosine Kinase Activator Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Glial Cell Differentiation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?