BECN1 and NLRP6

Number of citations of the paper that reports this interaction (PubMedID 36223738)
0

Data Source:
BioGRID (pull down)

		BECN1	NLRP6
Description		beclin 1	NLR family pyrin domain containing 6
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleus Cytoplasm Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Endosome Membrane Membrane Nuclear Body Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Protein-containing Complex Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Membraneless Organelle Canonical Inflammasome Complex NLRP6 Inflammasome Complex
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding GTPase Binding Molecular Adaptor Activity	Nucleotide Binding Lipopolysaccharide Binding Double-stranded RNA Binding Vasopressin Receptor Activity ATP Binding Signaling Adaptor Activity Signaling Receptor Activity Pattern Recognition Receptor Activity Peptide Binding Lipoteichoic Acid Binding Molecular Condensate Scaffold Activity
	Biological Process	Autophagosome Assembly Mitophagy Response To Hypoxia Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Targeting To Lysosome Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Mitotic Metaphase Chromosome Alignment JNK Cascade Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Iron(II) Ion Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Macroautophagy Regulation Of Macroautophagy Response To Nutrient Levels Regulation Of Cytokinesis Receptor Catabolic Process Response To Vitamin E Cellular Response To Amino Acid Starvation Phosphatidylinositol-3-phosphate Biosynthetic Process P38MAPK Cascade Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Engulfment Of Apoptotic Cell Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Neuron Development Amyloid-beta Metabolic Process Cell Division Defense Response To Virus Response To Other Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Aluminum Ion Cellular Response To Copper Ion Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Autophagosome Assembly Negative Regulation Of Lysosome Organization Positive Regulation Of Autophagosome Assembly Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Immune System Process Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Secretion Response To Bacterium Regulation Of Autophagy Negative Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Negative Regulation Of Toll-like Receptor Signaling Pathway Interleukin-18-mediated Signaling Pathway Wound Healing Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Innate Immune Response Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of Immune Response Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Defense Response To Virus Regulation Of Mucus Secretion Necroptotic Process Pyroptotic Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Neutrophil-mediated Killing Of Gram-positive Bacterium Antiviral Innate Immune Response NLRP6 Inflammasome Complex Assembly Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways		ISG15 antiviral mechanism Macroautophagy Ub-specific processing proteases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC RSV-host interactions
Drugs		Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS		Type 2 diabetes (age of onset) ( 28060188)	Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)
Interacting Genes		61 interacting genes: AKT1 AMBRA1 ARAF ARNT BCL2 BCL2L1 BCL2L10 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 HERC5 HSPB6 ITCH ITPR1 ITPR3 ITSN1 KAT2A KDELR2 KLHL20 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 MST1 NF2 NLRP6 NXF1 PDGFRA PGK1 RACK1 RAF1 RIPK2 SENP3 SHD SMAD2 STK11 STYK1 TEAD2 TERT TSC1 UBC ULK1 WASHC1 XPO1 YES1	6 interacting genes: ATG12 ATG16L1 ATG5 BECN1 PIK3R1 SQSTM1
Entrez ID		8678	171389
HPRD ID		05087	14806
Ensembl ID		ENSG00000126581	ENSG00000174885
Uniprot IDs		A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4	P59044
PDB IDs		2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK 7BL1 8SOR 9C82 9MHF 9MHG 9MHH	6NCV 6NDJ
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Tyrosine Kinase Activity Protein Serine Kinase Activity Regulation Of Cell Population Proliferation ATP Binding Regulation Of Signal Transduction Signal Transduction Cellular Response To Stress Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Transferase Activity Cytoplasm Regulation Of Programmed Cell Death Protein Modification Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Nucleotide Binding Regulation Of Developmental Process Cell Population Proliferation Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Protein Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Negative Regulation Of Multicellular Organismal Process Regulation Of Epithelial Cell Proliferation	Autophagosome Macroautophagy Atg12-Atg5-Atg16 Complex Autophagy Of Mitochondrion Autophagy Autophagosome Assembly Autophagosome Organization Regulation Of Autophagy Phagophore Assembly Site Membrane Microautophagy Regulation Of Innate Immune Response Positive Regulation Of Viral Translation Vacuole Organization Positive Regulation Of Autophagy Atg8-family Ligase Activity Negative Stranded Viral RNA Replication Organelle Assembly Mitophagy Regulation Of Defense Response Response To Mitochondrial Depolarisation Response To Iron(II) Ion Positive Regulation Of Stress Granule Assembly Viral RNA Genome Replication Regulation Of Immune Response Cellular Response To Nitrogen Starvation Regulation Of Stress Granule Assembly Transferase Complex Regulation Of Cellular Component Organization Intracellular Transport Regulation Of Organelle Organization Aggrephagy Regulation Of Autophagosome Maturation Negative Regulation Of Immune System Process Phosphatidylinositol 3-kinase Binding Negative Regulation Of Defense Response To Virus Positive Regulation Of Catabolic Process Piecemeal Microautophagy Of The Nucleus Viral Genome Replication Nucleophagy Regulation Of Macroautophagy Cellular Localization Establishment Of Localization In Cell Regulation Of Immune System Process Phagophore Assembly Site Response To Iron Ion Regulation Of Toll-like Receptor 4 Signaling Pathway GTPase Binding Defense Response To Virus Nucleobase-containing Compound Biosynthetic Process Catabolic Process
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