BECN1 and GOPC

Number of citations of the paper that reports this interaction (PubMedID 12372286)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		BECN1	GOPC
Description		beclin 1	golgi associated PDZ and coiled-coil motif containing
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleus Cytoplasm Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Endosome Membrane Membrane Nuclear Body Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Protein-containing Complex Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex Cell Projection Synapse
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding GTPase Binding Molecular Adaptor Activity	Protein Binding Identical Protein Binding Transmembrane Transporter Binding Molecular Sequestering Activity
	Biological Process	Autophagosome Assembly Mitophagy Response To Hypoxia Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Targeting To Lysosome Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Mitotic Metaphase Chromosome Alignment JNK Cascade Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Iron(II) Ion Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Macroautophagy Regulation Of Macroautophagy Response To Nutrient Levels Regulation Of Cytokinesis Receptor Catabolic Process Response To Vitamin E Cellular Response To Amino Acid Starvation Phosphatidylinositol-3-phosphate Biosynthetic Process P38MAPK Cascade Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Engulfment Of Apoptotic Cell Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Neuron Development Amyloid-beta Metabolic Process Cell Division Defense Response To Virus Response To Other Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Aluminum Ion Cellular Response To Copper Ion Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Autophagosome Assembly Negative Regulation Of Lysosome Organization Positive Regulation Of Autophagosome Assembly Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface
Pathways		ISG15 antiviral mechanism Macroautophagy Ub-specific processing proteases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC RSV-host interactions	RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
Drugs		Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS		Type 2 diabetes (age of onset) ( 28060188)	Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Mild obesity-related type 2 diabetes ( 34737425) Night sleep phenotypes ( 27126917)
Interacting Genes		61 interacting genes: AKT1 AMBRA1 ARAF ARNT BCL2 BCL2L1 BCL2L10 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 HERC5 HSPB6 ITCH ITPR1 ITPR3 ITSN1 KAT2A KDELR2 KLHL20 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 MST1 NF2 NLRP6 NXF1 PDGFRA PGK1 RACK1 RAF1 RIPK2 SENP3 SHD SMAD2 STK11 STYK1 TEAD2 TERT TSC1 UBC ULK1 WASHC1 XPO1 YES1	71 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CEBPA CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 UBE3A VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1
Entrez ID		8678	57120
HPRD ID		05087	06024
Ensembl ID		ENSG00000126581	ENSG00000047932
Uniprot IDs		A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4	Q9HD26
PDB IDs		2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK 7BL1 8SOR 9C82 9MHF 9MHG 9MHH	2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6V84 6XNJ 7JZO 7JZP 7JZQ 7JZR
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Tyrosine Kinase Activity Protein Serine Kinase Activity Regulation Of Cell Population Proliferation ATP Binding Regulation Of Signal Transduction Signal Transduction Cellular Response To Stress Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Transferase Activity Cytoplasm Regulation Of Programmed Cell Death Protein Modification Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Nucleotide Binding Regulation Of Developmental Process Cell Population Proliferation Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Protein Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Negative Regulation Of Multicellular Organismal Process Regulation Of Epithelial Cell Proliferation	Response To Lipid Phagocytic Vesicle PDZ Domain Binding Golgi-associated Vesicle Membrane Response To Xenobiotic Stimulus Positive Regulation Of Cellular Component Biogenesis Phagocytosis, Engulfment Response To Vitamin Negative Regulation Of Cell Population Proliferation Regeneration Liver Development Response To Hormone Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Positive Regulation Of Reactive Oxygen Species Metabolic Process Glutamatergic Synapse Transcription Factor AP-1 Complex Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Scaffold Protein Binding SMAD Protein Signal Transduction Postsynapse To Nucleus Signaling Pathway Response To Muramyl Dipeptide Membrane Hyperpolarization Negative Regulation Of Skeletal Muscle Cell Differentiation Myeloid Leukocyte Differentiation Hormone-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Stem Cell Proliferation Signal Transduction Organic Hydroxy Compound Transport Integrated Stress Response Signaling Synaptic Signaling Via Neuropeptide Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production
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