BECN1 and WASH1

Number of citations of the paper that reports this interaction (PMID 23974797)
3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, two hybrid)

		BECN1	WASH1
Gene Name		beclin 1, autophagy related	WAS protein family homolog 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Nucleus Trans-Golgi Network Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Membrane Dendrite Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phagocytic Vesicle	Exocyst Early Endosome Early Endosome Membrane Recycling Endosome Recycling Endosome Membrane WASH Complex Invadopodium
	Molecular Function	Protein Binding	Actin Binding Protein Binding Ubiquitin Protein Ligase Binding Alpha-tubulin Binding
	Biological Process	Autophagic Vacuole Assembly Cytokinesis Response To Hypoxia Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Viral Process Positive Regulation Of Macroautophagy CVT Pathway Response To Vitamin E Response To Drug Negative Regulation Of Apoptotic Process Nucleophagy Late Endosome To Vacuole Transport Neuron Development Beta-amyloid Metabolic Process Regulation Of Catalytic Activity Defense Response To Virus Cellular Response To Aluminum Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Mitochondrion Degradation	Exocytosis Endosomal Transport Extracellular Matrix Disassembly Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Retrograde Transport, Endosome To Plasma Membrane
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AMBRA1 ATG14 ATG3 BCL2 BCL2L1 CASP3 CDKN2A GFI1B GOPC ITCH NEDD4 PIK3R4 TRAF6 WASH1 XPO1	5 interactors: BECN1 BLOC1S2 KIAA0196 KIAA1033 RNF2
Entrez ID		8678	100287171
HPRD ID		05087
Ensembl ID		ENSG00000126581
Uniprot IDs		E7EV84 Q14457	A8K0Z3
PDB IDs		2P1L 2PON 3DVU 4DDP
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Apoptotic Mitochondrial Changes Protein K63-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Stress Intracellular Transport Intracellular Receptor Signaling Pathway Regulation Of Execution Phase Of Apoptosis Regulation Of Autophagy Regulation Of Organelle Organization Release Of Cytochrome C From Mitochondria Establishment Of Localization In Cell Protein Ubiquitination Apoptotic Process Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Cellular Localization Cellular Response To Starvation Cell Death Death Regulation Of T Cell Proliferation Regulation Of Establishment Of Protein Localization Organelle Organization Autophagy Mitochondrion Organization Regulation Of Lymphocyte Activation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Localization Cellular Response To Nutrient Levels Response To Starvation Regulation Of Protein Localization Regulation Of Intracellular Transport Neuron Apoptotic Process Macroautophagy Response To Stress Regulation Of B Cell Proliferation Regulation Of Cell Activation Neuron Death Cellular Response To Extracellular Stimulus Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Leukocyte Proliferation	Endosomal Transport Intracellular Transport Cellular Response To Aluminum Ion Establishment Of Localization In Cell Positive Regulation Of Mitochondrion Degradation CVT Pathway Histone H2A-K119 Monoubiquitination Cellular Localization Response To Aluminum Ion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Mitochondrion Degradation Mitochondrial Outer Membrane Permeabilization Platelet Dense Granule Organization Histone H2A Monoubiquitination Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Macroautophagy Histone H2A Ubiquitination Endomembrane System Organization Cellular Response To Nitrogen Starvation Positive Regulation Of Mitochondrial Membrane Permeability Response To Vitamin E Histone Monoubiquitination Anterograde Synaptic Vesicle Transport Nucleophagy Beta-amyloid Metabolic Process Microtubule Nucleation Melanosome Organization Protein Targeting To Vacuole Pigment Granule Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Epidermal Growth Factor Stimulus Establishment Of Protein Localization To Vacuole Microtubule Polymerization Anterograde Axon Cargo Transport Response To Epidermal Growth Factor Endosome Organization Histone Ubiquitination Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Autophagy Regulation Of Membrane Permeability Transport Secretory Granule Organization Protein Monoubiquitination Microtubule Polymerization Or Depolymerization Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Autophagic Vacuole Assembly Axon Cargo Transport Cellular Defense Response Lysosome Organization
Tagcloud ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1
Tagcloud (Difference) ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1
Tagcloud (Intersection) ?