ITPR3 and ANK1

Number of citations: 0 (PubMedID 15051494)
Data Source: HPRD (in vitro, in vivo)

		ITPR3	ANK1
Name		inositol 1,4,5-trisphosphate receptor type 3	ankyrin 1
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Brush Border Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Apical Part Of Cell Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band A Band Sarcolemma Neuron Projection Postsynaptic Membrane Cell Periphery Ankyrin-1 Complex
	Molecular Function	Inositol Hexakisphosphate Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Intracellularly Gated Calcium Channel Activity Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Transmembrane Transporter Binding ATPase Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Calcium-mediated Signaling Platelet Activation Monoatomic Ion Transmembrane Transport Sensory Perception Of Taste Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Response To Calcium Ion Calcium Ion Homeostasis Transmembrane Transport Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Golgi Vesicle Transport Protein Localization To Plasma Membrane
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Sensory perception of sweet, bitter, and umami (glutamate) taste Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport
Drugs		Caffeine	None
Diseases		Type I diabetes mellitus	Hereditary spherocytosis (SPH)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma and attention deficit hyperactivity disorder ( 31619474 ) Body mass index ( 26426971 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Crohn's disease ( 23850713 ) Educational attainment ( 23722424 ) Hodgkin's lymphoma ( 30194254 ) Multiple sclerosis and body mass index (pleiotropy) ( 26920376 ) Obesity (extreme) ( 19553259 ) Phosphorus levels ( 20558539 ) Regular attendance at a gym or sports club ( 29970889 ) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	Apolipoprotein B levels ( 32203549 ) Birth weight ( 31043758 27680694 ) Corrected insulin response ( 24699409 ) Corrected insulin response adjusted for insulin sensitivity index ( 24699409 ) Glycated hemoglobin levels ( 20858683 34059833 31213470 24647736 28898252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) hemolysis of donated blood (osmotic) ( 34014839 ) High light scatter reticulocyte count ( 32888494 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Insulin levels adjusted for BMI ( 24699409 ) LDL cholesterol levels ( 32203549 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 28017375 32888494 27863252 ) Mean corpuscular volume ( 32888494 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Pulmonary function decline ( 22424883 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 28957414 32888494 27863252 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 32888494 27863252 ) Sleep duration ( 30531941 ) Type 2 diabetes ( 22456796 32499647 22885922 24509480 26818947 28869590 29358691 30054458 30297969 30718926 )
Novel Interactors		None recorded	1 novel interactors: CBR3
Interacting Genes		18 interacting genes: AKT1 ANK1 BAP1 BECN1 CABP1 ITPR1 MTDH MTNR1A MTNR1B SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	28 interacting genes: BLOC1S6 CD44 EMD EMP1 EPB42 FXYD3 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC NRM OBSCN RBFA RHAG RTP2 RYR1 SLC30A8 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB STRIT1 TIAM1 TMEM203 TTN
Entrez ID		3710	286
HPRD ID		00926	01693
Ensembl ID		ENSG00000096433	ENSG00000029534
Uniprot IDs		A6H8K3 Q14573 Q59ES2	B3KX39 P16157
PDB IDs		6DQJ 6DQN 6DQS 6DQV 6DQZ 6DR0 6DR2 6DRA 6DRC 6UQK 7T3P 7T3Q 7T3R 7T3T 7T3U 8TK8 8TKD 8TKE 8TKF 8TKG 8TKH 8TKI 8TL9 8TLA	1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2 7TW3 7TW5 7TW6 7UZQ 7UZU 7V0K 7V0M 7V0S 7V0X 8CS9 8CSL 8CSV 8CTE
GO Terms Enriched among Interactors		Inositol 1,4,5 Trisphosphate Binding Store-operated Calcium Channel Activity Cation Channel Complex Calcium Channel Activity Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Calcium Ion Transport Monoatomic Ion Channel Activity Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis Metal Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Homeostatic Process Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Chemical Homeostasis Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Cellular Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Transmembrane Transport Intracellular Chemical Homeostasis ATPase Binding Single Fertilization Monoatomic Cation Channel Activity Melatonin Receptor Activity Plasma Membrane Response To Calcium Ion Fertilization Response To Metal Ion Membrane Positive Regulation Of Monoatomic Ion Transport Intracellularly Gated Calcium Channel Activity Negative Regulation Of Dendrite Morphogenesis Cellular Response To Hydrogen Peroxide Calcium Import Into The Mitochondrion Manganese Ion Transport Actinin Binding Positive Regulation Of Calcium Ion Transport Response To Hydrogen Peroxide Mitochondrial Calcium Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Response To Decreased Oxygen Levels Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Sequestering Of Calcium Ion	Ankyrin Binding Ankyrin-1 Complex Spectrin Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Z Disc Chemical Homeostasis Bicarbonate Transport Plasma Membrane M Band Cortical Cytoskeleton Structural Constituent Of Cytoskeleton Intracellular Chemical Homeostasis Actin Filament Binding Actin Filament Capping Homeostatic Process Negative Regulation Of Actin Filament Depolymerization Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Cellular Homeostasis Bicarbonate Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Membrane Intracellularly Gated Calcium Channel Activity Monoatomic Anion Transmembrane Transporter Activity Cortical Actin Cytoskeleton Inorganic Ion Transmembrane Transport Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Sarcoplasmic Reticulum Cell Cortex Negative Regulation Of Protein-containing Complex Disassembly Actin Cytoskeleton Organization Calmodulin Binding Transmembrane Transport Regulation Of Protein Depolymerization Intracellular Monoatomic Cation Homeostasis Actin Filament-based Process Antiporter Activity Secretory Granule Membrane Chloride Transmembrane Transport Focal Adhesion Cell-matrix Adhesion Chloride Transport Cytoplasmic Side Of Plasma Membrane Multicellular Organismal-level Iron Ion Homeostasis I Band Cell-cell Contact Zone