ITPR3 and ITPR1

Number of citations of the paper that reports this interaction (PMID 7559486)
30

Data Source:
HPRD (in vivo)

		ITPR3	ITPR1
Gene Name		inositol 1,4,5-trisphosphate receptor, type 3	inositol 1,4,5-trisphosphate receptor, type 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane
	Molecular Function	Inositol Hexakisphosphate Binding Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Memory Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Protein Homooligomerization Protein Heterooligomerization Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport	Response To Hypoxia Energy Reserve Metabolic Process Calcium Ion Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism cGMP effects Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Educational attainment ( 23722424) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539)	Airflow obstruction ( 22837378) Breast cancer ( 23535729) Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: AKT1 ANK1 CABP1 ITPR1 SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	29 interactors: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 ITPR3 ITPRIP LYN MRVI1 PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		3710	3708
HPRD ID		00926	00925
Ensembl ID		ENSG00000096433	ENSG00000150995
Uniprot IDs		A6H8K3 Q14573 Q59ES2	B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Cation Transport Metal Ion Transport Axonogenesis Cation Transmembrane Transport Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Ion Transport Cell Projection Organization Cell Morphogenesis Involved In Differentiation Platelet Activation Ion Transmembrane Transport Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Nervous System Development Generation Of Neurons Regulation Of Body Fluid Levels Neurogenesis Cell Morphogenesis Transmembrane Transport Neuron Differentiation Transport Cell Development Response To External Stimulus Locomotion Blood Coagulation Hemostasis Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Movement Of Cell Or Subcellular Component Multicellular Organismal Development Wound Healing Regulation Of Ion Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Manganese Ion Transport Cell Activation Response To Wounding Developmental Process System Development Chemical Homeostasis Response To Oxidative Stress Regulation Of Intracellular Transport Cell Differentiation	Regulation Of Calcium Ion Transport Regulation Of Ion Transport Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Protein Localization Blood Coagulation Hemostasis Regulation Of Cellular Localization Wound Healing Platelet Activation Cell Activation Regulation Of Transmembrane Transporter Activity Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Response To Organonitrogen Compound Regulation Of Intracellular Transport Signaling Regulation Of Platelet Aggregation Cell Communication Response To Organic Substance Response To Organic Cyclic Compound Response To Metal Ion Cellular Response To Stimulus Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Transport Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Intracellular Signal Transduction Response To Stimulus Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Platelet Activation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Cell Activation Regulation Of Establishment Of Protein Localization Response To Inorganic Substance Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor
Tagcloud ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?