BECN1 and GFI1B

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BECN1	GFI1B
Gene Name		beclin 1, autophagy related	growth factor independent 1B transcription repressor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Nucleus Trans-Golgi Network Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Membrane Dendrite Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phagocytic Vesicle	Nucleus Transcription Factor Complex Nuclear Matrix
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Autophagic Vacuole Assembly Cytokinesis Response To Hypoxia Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Viral Process Positive Regulation Of Macroautophagy CVT Pathway Response To Vitamin E Response To Drug Negative Regulation Of Apoptotic Process Nucleophagy Late Endosome To Vacuole Transport Neuron Development Beta-amyloid Metabolic Process Regulation Of Catalytic Activity Defense Response To Virus Cellular Response To Aluminum Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Mitochondrion Degradation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Chromatin Modification Hemopoiesis Regulation Of Histone H3-K4 Methylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AMBRA1 ATG14 ATG3 BCL2 BCL2L1 CASP3 CDKN2A GFI1B GOPC ITCH NEDD4 PIK3R4 TRAF6 WASH1 XPO1	71 interactors: ACTN1 AES AGPAT6 AGRN AJUBA ANKS3 ATXN2 BECN1 BEGAIN BEND5 BRCA1 BRE CCDC136 CCDC85B CENPB CENPJ COPS5 DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 PSMA3 RAB11FIP4 RCHY1 RINT1 RNF31 RUNDC3A TAF1 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRD1 ZNRF3
Entrez ID		8678	8328
HPRD ID		05087	05088
Ensembl ID		ENSG00000126581	ENSG00000165702
Uniprot IDs		E7EV84 Q14457	Q5VTD9
PDB IDs		2P1L 2PON 3DVU 4DDP
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Apoptotic Mitochondrial Changes Protein K63-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Stress Intracellular Transport Intracellular Receptor Signaling Pathway Regulation Of Execution Phase Of Apoptosis Regulation Of Autophagy Regulation Of Organelle Organization Release Of Cytochrome C From Mitochondria Establishment Of Localization In Cell Protein Ubiquitination Apoptotic Process Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Cellular Localization Cellular Response To Starvation Cell Death Death Regulation Of T Cell Proliferation Regulation Of Establishment Of Protein Localization Organelle Organization Autophagy Mitochondrion Organization Regulation Of Lymphocyte Activation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Localization Cellular Response To Nutrient Levels Response To Starvation Regulation Of Protein Localization Regulation Of Intracellular Transport Neuron Apoptotic Process Macroautophagy Response To Stress Regulation Of B Cell Proliferation Regulation Of Cell Activation Neuron Death Cellular Response To Extracellular Stimulus Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Leukocyte Proliferation	Regulation Of Cellular Process Cell Communication Regulation Of Cellular Component Organization Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Signaling Cellular Response To Stimulus Signal Transduction Response To Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Growth Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Canonical Wnt Signaling Pathway Developmental Process Secretion Negative Regulation Of Signaling Regulation Of Locomotion Cellular Process Regulation Of Cellular Component Movement Focal Adhesion Assembly Protein Localization Protein Ubiquitination Cellular Localization Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Cell-substrate Adhesion Adherens Junction Assembly Cell Differentiation Cellular Component Assembly Neurogenesis Auditory Receptor Cell Fate Commitment Anatomical Structure Development Regulation Of Gene Expression Regulation Of Proteolysis Regulation Of Apoptotic Process Cell-substrate Junction Assembly Regulation Of I-kappaB Kinase/NF-kappaB Signaling Secretion By Cell Regulation Of Cell Proliferation Receptor Clustering Regulation Of Vesicle-mediated Transport
Tagcloud ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Difference) ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Intersection) ?