ITPR3 and CABP1

Number of citations of the paper that reports this interaction (PMID 12032348)
45

Data Source:
HPRD (in vivo)

		ITPR3	CABP1
Gene Name		inositol 1,4,5-trisphosphate receptor, type 3	calcium binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell	Golgi Membrane Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Cell Junction Dendrite Neuronal Cell Body Protein Complex Postsynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Inositol Hexakisphosphate Binding Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Enzyme Inhibitor Activity Calcium Ion Binding Protein Binding Nuclear Localization Sequence Binding Protein Domain Specific Binding Type 3 Metabotropic Glutamate Receptor Binding Protein Homodimerization Activity Ion Channel Binding Calcium-dependent Protein Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Memory Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Protein Homooligomerization Protein Heterooligomerization Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport	Negative Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Catalytic Activity Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Educational attainment ( 23722424) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539)
Protein-Protein Interactions		13 interactors: AKT1 ANK1 CABP1 ITPR1 SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	9 interactors: CACNA1A CACNA1C CSNK2A2 FOS GRK5 ITPR1 ITPR3 NMT1 PPP3R1
Entrez ID		3710	9478
HPRD ID		00926	12025
Ensembl ID		ENSG00000096433	ENSG00000157782
Uniprot IDs		A6H8K3 Q14573 Q59ES2	C9J8G2 Q9NZU7
PDB IDs			2K7B 2K7C 2K7D 2LAN 2LAP 3OX5 3OX6
Enriched GO Terms of Interacting Partners?		Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Cation Transport Metal Ion Transport Axonogenesis Cation Transmembrane Transport Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Ion Transport Cell Projection Organization Cell Morphogenesis Involved In Differentiation Platelet Activation Ion Transmembrane Transport Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Nervous System Development Generation Of Neurons Regulation Of Body Fluid Levels Neurogenesis Cell Morphogenesis Transmembrane Transport Neuron Differentiation Transport Cell Development Response To External Stimulus Locomotion Blood Coagulation Hemostasis Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Movement Of Cell Or Subcellular Component Multicellular Organismal Development Wound Healing Regulation Of Ion Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Manganese Ion Transport Cell Activation Response To Wounding Developmental Process System Development Chemical Homeostasis Response To Oxidative Stress Regulation Of Intracellular Transport Cell Differentiation	Inositol Phosphate-mediated Signaling Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Energy Reserve Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Regulation Of Cellular Localization Calcium Ion Transport Into Cytosol Cell Death Cytosolic Calcium Ion Transport Death Regulation Of Insulin Secretion Calcium Ion Transmembrane Transport Cell Surface Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Protein Transport Regulation Of Hormone Secretion Fc Receptor Signaling Pathway Signaling Cellular Calcium Ion Homeostasis Calcium Ion Transport Energy Derivation By Oxidation Of Organic Compounds Cell Communication Calcium Ion Homeostasis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Secretion Cellular Metal Ion Homeostasis Cellular Response To Stimulus Generation Of Precursor Metabolites And Energy Apoptotic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Programmed Cell Death Single-organism Behavior Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Metal Ion Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Ion Homeostasis Intrinsic Apoptotic Signaling Pathway Behavior Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Secretion Calcium Ion Import Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Tagcloud ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually
Tagcloud (Difference) ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually
Tagcloud (Intersection) ?