ITPR3 and TRPC4

Number of citations of the paper that reports this interaction (PMID 11290752)
57

Data Source:
HPRD (in vitro, two hybrid)

		ITPR3	TRPC4
Gene Name		inositol 1,4,5-trisphosphate receptor, type 3	transient receptor potential cation channel, subfamily C, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell	Plasma Membrane Caveola Cell-cell Junction Cell Surface Basolateral Plasma Membrane Cortical Cytoskeleton Calcium Channel Complex
	Molecular Function	Inositol Hexakisphosphate Binding Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Memory Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Protein Homooligomerization Protein Heterooligomerization Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport	Calcium Ion Transport Axon Guidance Gamma-aminobutyric Acid Secretion Ion Transmembrane Transport Oligodendrocyte Differentiation Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization	Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling
Drugs
Diseases
GWAS		Educational attainment ( 23722424) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539)	Age-related macular degeneration ( 23326517) Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: AKT1 ANK1 CABP1 ITPR1 SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	9 interactors: ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5
Entrez ID		3710	7223
HPRD ID		00926	09154
Ensembl ID		ENSG00000096433	ENSG00000133107
Uniprot IDs		A6H8K3 Q14573 Q59ES2	Q3KR50 Q9UBN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Cation Transport Metal Ion Transport Axonogenesis Cation Transmembrane Transport Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Ion Transport Cell Projection Organization Cell Morphogenesis Involved In Differentiation Platelet Activation Ion Transmembrane Transport Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Nervous System Development Generation Of Neurons Regulation Of Body Fluid Levels Neurogenesis Cell Morphogenesis Transmembrane Transport Neuron Differentiation Transport Cell Development Response To External Stimulus Locomotion Blood Coagulation Hemostasis Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Movement Of Cell Or Subcellular Component Multicellular Organismal Development Wound Healing Regulation Of Ion Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Manganese Ion Transport Cell Activation Response To Wounding Developmental Process System Development Chemical Homeostasis Response To Oxidative Stress Regulation Of Intracellular Transport Cell Differentiation	Calcium Ion Transmembrane Transport Inositol Phosphate-mediated Signaling Calcium Ion Transport Metal Ion Transport Cellular Chemical Homeostasis Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Cation Transport Cellular Homeostasis Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemical Homeostasis Cation Transmembrane Transport Ion Transport Cellular Ion Homeostasis Energy Reserve Metabolic Process Immune Response-regulating Signaling Pathway Second-messenger-mediated Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Immune Response Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of Secretion Regulation Of Peptide Hormone Secretion Neurotrophin Signaling Pathway Homeostatic Process Fc-epsilon Receptor Signaling Pathway Response To Stimulus Phagocytosis Regulation Of Hormone Secretion Fc Receptor Signaling Pathway Calcium Ion Transport Into Cytosol Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually	analyse anatomically convey drg drgs fibres ganglia ganglion refined somatosensation string trigeminal trpa1 trpc1 trpc3 trpc5 trpm3 trpm4 trpm5 trpm6 trpm7 trpm8 trpml1 trpp2 trpv1 trpv2 trpv4 vertebral
Tagcloud (Difference) ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually	analyse anatomically convey drg drgs fibres ganglia ganglion refined somatosensation string trigeminal trpa1 trpc1 trpc3 trpc5 trpm3 trpm4 trpm5 trpm6 trpm7 trpm8 trpml1 trpp2 trpv1 trpv2 trpv4 vertebral
Tagcloud (Intersection) ?