ANK1 and SLC4A1

Number of citations of the paper that reports this interaction (PubMedID 40355756)
172

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		ANK1	SLC4A1
Description		ankyrin 1	solute carrier family 4 member 1 (Diego blood group)
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band A Band Sarcolemma Neuron Projection Postsynaptic Membrane Cell Periphery Ankyrin-1 Complex	Cytoplasm Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Z Disc Cortical Cytoskeleton Extracellular Exosome Blood Microparticle Ankyrin-1 Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Transmembrane Transporter Binding ATPase Binding	Solute:inorganic Anion Antiporter Activity Protein Binding Cytoskeletal Protein Binding Monoatomic Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Antiporter Activity Hemoglobin Binding Ankyrin Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Chloride:bicarbonate Antiporter Activity
	Biological Process	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Golgi Vesicle Transport Protein Localization To Plasma Membrane	Monoatomic Ion Transport Monoatomic Anion Transport Chloride Transport Intracellular Monoatomic Ion Homeostasis Blood Coagulation Bicarbonate Transport Plasma Membrane Phospholipid Scrambling Negative Regulation Of Urine Volume PH Elevation Erythrocyte Development Regulation Of Intracellular PH Transmembrane Transport Protein Localization To Plasma Membrane Chloride Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Bicarbonate transporters Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
Drugs
Diseases		Hereditary spherocytosis (SPH)	Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP) Distal renal tubular acidosis (RTA type 1) Hereditary spherocytosis (SPH) Hereditary elliptocytosis (HE)
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758 27680694) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Glycated hemoglobin levels ( 20858683 34059833 31213470 24647736 28898252) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Insulin levels adjusted for BMI ( 24699409) LDL cholesterol levels ( 32203549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 28017375 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Pulmonary function decline ( 22424883) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration ( 30531941) Type 2 diabetes ( 22456796 32499647 22885922 24509480 26818947 28869590 29358691 30054458 30297969 30718926)	Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Urate levels ( 31578528)
Interacting Genes		28 interacting genes: BLOC1S6 CD44 EMD EMP1 EPB42 FXYD3 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC NRM OBSCN RBFA RHAG RTP2 RYR1 SLC30A8 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB STRIT1 TIAM1 TMEM203 TTN	17 interacting genes: ACTC1 ADAM33 ANK1 BLOC1S6 BMP10 CA2 CA4 CANX CDKN2A CFHR5 EPB41 EPB42 LYN RHAG SLC4A1AP SYK TMEM60
Entrez ID		286	6521
HPRD ID		01693	00175
Ensembl ID		ENSG00000029534	ENSG00000004939
Uniprot IDs		B3KX39 P16157	P02730
PDB IDs		1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2 7TW3 7TW5 7TW6 7UZQ 7UZU 7V0K 7V0M 7V0S 7V0X 8CS9 8CSL 8CSV 8CTE	1BH7 1BNX 1BTQ 1BTR 1BTS 1BTT 1BZK 1HYN 2BTA 2BTB 3BTB 4KY9 4YZF 7TVZ 7TW0 7TW1 7TW2 7TW3 7TW5 7TW6 7TY4 7TY6 7TY7 7TY8 7TYA 7UZ3 7UZU 7UZV 7V07 7V0K 7V0M 7V0T 7V0U 7V0Y 7V19 8CRQ 8CRR 8CRT 8CS9 8CSL 8CSV 8CSY 8CT3 8CTE 8T3R 8T3U 8T44 8T45 8T47 8T6U 8T6V
Enriched GO Terms of Interacting Partners?		Ankyrin Binding Ankyrin-1 Complex Spectrin Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Z Disc Chemical Homeostasis Bicarbonate Transport Plasma Membrane M Band Cortical Cytoskeleton Structural Constituent Of Cytoskeleton Intracellular Chemical Homeostasis Actin Filament Binding Actin Filament Capping Homeostatic Process Negative Regulation Of Actin Filament Depolymerization Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Cellular Homeostasis Bicarbonate Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Membrane Intracellularly Gated Calcium Channel Activity Monoatomic Anion Transmembrane Transporter Activity Cortical Actin Cytoskeleton Inorganic Ion Transmembrane Transport Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Sarcoplasmic Reticulum Cell Cortex Negative Regulation Of Protein-containing Complex Disassembly Actin Cytoskeleton Organization Calmodulin Binding Transmembrane Transport Regulation Of Protein Depolymerization Intracellular Monoatomic Cation Homeostasis Actin Filament-based Process Antiporter Activity Secretory Granule Membrane Chloride Transmembrane Transport Focal Adhesion Cell-matrix Adhesion Chloride Transport Cytoplasmic Side Of Plasma Membrane Multicellular Organismal-level Iron Ion Homeostasis I Band Cell-cell Contact Zone	Ankyrin-1 Complex Secretion Secretion By Cell Spectrin-associated Cytoskeleton Carbonate Dehydratase Activity Carbon Dioxide Transport Actomyosin Structure Organization Structural Constituent Of Cytoskeleton Bicarbonate Transport Negative Regulation Of B Cell Proliferation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Lectin Fc-epsilon Receptor Signaling Pathway One-carbon Compound Transport Regulation Of B Cell Activation Multicellular Organismal-level Iron Ion Homeostasis Spectrin Binding Cortical Cytoskeleton Positive Regulation Of Leukocyte Apoptotic Process Regulation Of Platelet Aggregation Regulation Of Mast Cell Degranulation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of B Cell Activation Negative Regulation Of Protein Serine/threonine Kinase Activity Fc-gamma Receptor Signaling Pathway Kidney Development Phosphoprotein Binding Protein-containing Complex Ligase Inhibitor Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Methylammonium Transmembrane Transporter Activity Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Exocytosis Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Phosphorylation Multicellular Organismal-level Homeostasis B Cell Receptor Signaling Pathway Regulation Of Platelet Activation Cell Surface Pattern Recognition Receptor Signaling Pathway Homeostatic Process Chemical Homeostasis Fc Receptor Signaling Pathway Cardiac Muscle Tissue Morphogenesis Basolateral Plasma Membrane Positive Regulation Of Dipeptide Transmembrane Transport
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