ANK1 and EPB42

Number of citations of the paper that reports this interaction (PMID 2968981)
19

Data Source:
HPRD (in vitro)

		ANK1	EPB42
Gene Name		ankyrin 1, erythrocytic	erythrocyte membrane protein band 4.2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma Cortical Cytoskeleton M Band Sarcolemma Postsynaptic Membrane	Cytoskeleton Plasma Membrane Cortical Cytoskeleton
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Enzyme Binding Spectrin Binding ATPase Binding	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding
	Biological Process	Porphyrin-containing Compound Biosynthetic Process Exocytosis ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Axon Guidance Positive Regulation Of Organelle Organization Monovalent Inorganic Cation Transport Maintenance Of Epithelial Cell Apical/basal Polarity Erythrocyte Development Iron Ion Homeostasis Protein Targeting To Plasma Membrane	Cell Morphogenesis Regulation Of Cell Shape Peptide Cross-linking Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Iron Ion Homeostasis
Pathways		Interaction between L1 and Ankyrins CHL1 interactions Axon guidance Neurofascin interactions NrCAM interactions L1CAM interactions
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 20858683) Pulmonary function decline ( 22424883) Type 2 diabetes ( 22456796)
Protein-Protein Interactions		18 interactors: BLOC1S6 CD44 EPB42 ITPR3 KCTD6 L1CAM NBPF3 NEDD8 NFASC OBSCN RHAG SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB TIAM1 TTN	13 interactors: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12
Entrez ID		286	2038
HPRD ID		01693	01517
Ensembl ID		ENSG00000029534	ENSG00000166947
Uniprot IDs		B3KX39 P16157	F5H563 P16452
PDB IDs		1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2
Enriched GO Terms of Interacting Partners?		Cell Development Anatomical Structure Morphogenesis Axon Guidance Movement Of Cell Or Subcellular Component Neuron Projection Development Locomotion Axonogenesis Anatomical Structure Development Bicarbonate Transport Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Chemotaxis Response To Growth Factor Cell Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Developmental Process Neuron Differentiation Cell Morphogenesis Involved In Differentiation Actin Filament Capping Cell Projection Organization Blood Coagulation Multicellular Organismal Development Hemostasis Negative Regulation Of Actin Filament Depolymerization Response To External Stimulus Cell Projection Morphogenesis Regulation Of Actin Filament Depolymerization Cell Part Morphogenesis Chemical Homeostasis System Development Negative Regulation Of Actin Filament Polymerization Homeostatic Process Cellular Chemical Homeostasis Negative Regulation Of Protein Polymerization Ion Homeostasis Regulation Of Body Fluid Levels Negative Regulation Of Protein Complex Disassembly Wound Healing Generation Of Neurons Hemopoiesis Regulation Of Protein Depolymerization Nervous System Development Neurogenesis Regulation Of Protein Complex Disassembly Response To Wounding Cellular Homeostasis Immune System Development	Movement Of Cell Or Subcellular Component Chemotaxis Locomotion Axon Guidance Neuron Projection Development Blood Coagulation Hemostasis Neuron Development Bicarbonate Transport Axonogenesis Cell Morphogenesis Ion Homeostasis Axon Development Cell Development Regulation Of Body Fluid Levels Response To External Stimulus Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Protein Targeting To Plasma Membrane Wound Healing Erythrocyte Development Cell Projection Organization Regulation Of Intracellular PH Myeloid Cell Differentiation Regulation Of Cellular PH Neuron Projection Morphogenesis Actin Filament Capping Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Actin Filament Depolymerization Homeostatic Process Organelle Organization P38MAPK Cascade Positive Regulation Of Platelet Aggregation Protein Localization To T-tubule Muscle Cell Differentiation Vesicle-mediated Transport Regulation Of PH Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Establishment Of Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Cell Differentiation Chemical Homeostasis Cell Part Morphogenesis Generation Of Neurons Negative Regulation Of Protein Polymerization Protein Stabilization Protein Secretion By Platelet
Tagcloud ?		antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1	aplastic cbc cholelithiasis corpuscular crisis deformability dimax ektacytometry entails folic fragility hemolytic hemolyze hgb immunizations instituted mchc omin osmolality promptly repleted reticulocytes reticulocytosis sib sibs spherocytes spherocytosis splenectomy splenomegaly
Tagcloud (Difference) ?		antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spta1 sptb ugt1a1	aplastic cbc cholelithiasis corpuscular crisis deformability dimax ektacytometry entails folic fragility hemolytic hemolyze hgb immunizations instituted mchc omin osmolality promptly repleted reticulocytes reticulocytosis sib sibs spherocytosis splenectomy splenomegaly
Tagcloud (Intersection) ?		epb42 spherocytes