ANK1 and OBSCN

Number of citations of the paper that reports this interaction (PMID 12527750)
46

Data Source:
HPRD (two hybrid, in vitro)

		ANK1	OBSCN
Gene Name		ankyrin 1, erythrocytic	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma Cortical Cytoskeleton M Band Sarcolemma Postsynaptic Membrane	Cytosol Myofibril Z Disc M Band
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Enzyme Binding Spectrin Binding ATPase Binding	Protein Serine/threonine Kinase Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Ankyrin Binding Titin Binding Metal Ion Binding
	Biological Process	Porphyrin-containing Compound Biosynthetic Process Exocytosis ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Axon Guidance Positive Regulation Of Organelle Organization Monovalent Inorganic Cation Transport Maintenance Of Epithelial Cell Apical/basal Polarity Erythrocyte Development Iron Ion Homeostasis Protein Targeting To Plasma Membrane	Protein Phosphorylation Small GTPase Mediated Signal Transduction Multicellular Organismal Development Positive Regulation Of Rho GTPase Activity Protein Localization To M-band Positive Regulation Of Apoptotic Process Sarcomere Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Interaction between L1 and Ankyrins CHL1 interactions Axon guidance Neurofascin interactions NrCAM interactions L1CAM interactions	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 20858683) Pulmonary function decline ( 22424883) Type 2 diabetes ( 22456796)
Protein-Protein Interactions		18 interactors: BLOC1S6 CD44 EPB42 ITPR3 KCTD6 L1CAM NBPF3 NEDD8 NFASC OBSCN RHAG SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB TIAM1 TTN	6 interactors: ANK1 ANK2 BRCA1 CALM1 MYH2 TTN
Entrez ID		286	84033
HPRD ID		01693	10551
Ensembl ID		ENSG00000029534	ENSG00000154358
Uniprot IDs		B3KX39 P16157	H3BPX2 Q5VST9
PDB IDs		1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2	1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2YZ8
Enriched GO Terms of Interacting Partners?		Cell Development Anatomical Structure Morphogenesis Axon Guidance Movement Of Cell Or Subcellular Component Neuron Projection Development Locomotion Axonogenesis Anatomical Structure Development Bicarbonate Transport Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Chemotaxis Response To Growth Factor Cell Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Developmental Process Neuron Differentiation Cell Morphogenesis Involved In Differentiation Actin Filament Capping Cell Projection Organization Blood Coagulation Multicellular Organismal Development Hemostasis Negative Regulation Of Actin Filament Depolymerization Response To External Stimulus Cell Projection Morphogenesis Regulation Of Actin Filament Depolymerization Cell Part Morphogenesis Chemical Homeostasis System Development Negative Regulation Of Actin Filament Polymerization Homeostatic Process Cellular Chemical Homeostasis Negative Regulation Of Protein Polymerization Ion Homeostasis Regulation Of Body Fluid Levels Negative Regulation Of Protein Complex Disassembly Wound Healing Generation Of Neurons Hemopoiesis Regulation Of Protein Depolymerization Nervous System Development Neurogenesis Regulation Of Protein Complex Disassembly Response To Wounding Cellular Homeostasis Immune System Development	Muscle Contraction Muscle System Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Plasma Membrane Organization Membrane Organization Actin-myosin Filament Sliding Muscle Filament Sliding Positive Regulation Of Cation Channel Activity Protein Targeting To Plasma Membrane Actin-mediated Cell Contraction Exocytosis Positive Regulation Of Ion Transmembrane Transporter Activity Cardiac Muscle Contraction Positive Regulation Of Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Actin Filament-based Movement Heart Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Endomembrane System Organization Platelet Degranulation Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transport Establishment Of Protein Localization To Plasma Membrane Regulation Of Calcium Ion Transport Into Cytosol Striated Muscle Contraction Secretion By Cell Vesicle-mediated Transport Regulation Of Striated Muscle Contraction Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Calcium-mediated Signaling Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Protein Localization To T-tubule Wound Healing Response To Calcium Ion Secretion Response To External Stimulus Response To Wounding Positive Regulation Of Histone H3-K9 Acetylation T-tubule Organization Protein Localization To M-band Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity
Tagcloud ?		antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 plau ppp1ca prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Difference) ?		antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 plau ppp1ca prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Intersection) ?