ANK1 and SPTB

Number of citations of the paper that reports this interaction (PMID 2141335)
24

Data Source:
BioGRID (pull down)

		ANK1	SPTB
Gene Name		ankyrin 1, erythrocytic	spectrin, beta, erythrocytic
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma Cortical Cytoskeleton M Band Sarcolemma Postsynaptic Membrane	Cytoplasm Cytosol Spectrin Cell Surface Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Protein Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Enzyme Binding Spectrin Binding ATPase Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Porphyrin-containing Compound Biosynthetic Process Exocytosis ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Axon Guidance Positive Regulation Of Organelle Organization Monovalent Inorganic Cation Transport Maintenance Of Epithelial Cell Apical/basal Polarity Erythrocyte Development Iron Ion Homeostasis Protein Targeting To Plasma Membrane	Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Axon Guidance Hemopoiesis Actin Filament Capping
Pathways		Interaction between L1 and Ankyrins CHL1 interactions Axon guidance Neurofascin interactions NrCAM interactions L1CAM interactions	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 20858683) Pulmonary function decline ( 22424883) Type 2 diabetes ( 22456796)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		18 interactors: BLOC1S6 CD44 EPB42 ITPR3 KCTD6 L1CAM NBPF3 NEDD8 NFASC OBSCN RHAG SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB TIAM1 TTN	11 interactors: ADD1 ANK1 AP1G1 CSRP3 DMTN EPB41 MAPT NCAM1 SPTA1 SPTAN1 YWHAQ
Entrez ID		286	6710
HPRD ID		01693	01686
Ensembl ID		ENSG00000029534	ENSG00000070182
Uniprot IDs		B3KX39 P16157	P11277 Q59FP5 Q86TX9
PDB IDs		1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2	1S35 3EDU 3F57 3KBT 3KBU 3LBX
Enriched GO Terms of Interacting Partners?		Cell Development Anatomical Structure Morphogenesis Axon Guidance Movement Of Cell Or Subcellular Component Neuron Projection Development Locomotion Axonogenesis Anatomical Structure Development Bicarbonate Transport Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Chemotaxis Response To Growth Factor Cell Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Developmental Process Neuron Differentiation Cell Morphogenesis Involved In Differentiation Actin Filament Capping Cell Projection Organization Blood Coagulation Multicellular Organismal Development Hemostasis Negative Regulation Of Actin Filament Depolymerization Response To External Stimulus Cell Projection Morphogenesis Regulation Of Actin Filament Depolymerization Cell Part Morphogenesis Chemical Homeostasis System Development Negative Regulation Of Actin Filament Polymerization Homeostatic Process Cellular Chemical Homeostasis Negative Regulation Of Protein Polymerization Ion Homeostasis Regulation Of Body Fluid Levels Negative Regulation Of Protein Complex Disassembly Wound Healing Generation Of Neurons Hemopoiesis Regulation Of Protein Depolymerization Nervous System Development Neurogenesis Regulation Of Protein Complex Disassembly Response To Wounding Cellular Homeostasis Immune System Development	Actin Filament Capping Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Depolymerization Cytoskeleton Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Protein Complex Disassembly Negative Regulation Of Protein Complex Assembly Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Cell Differentiation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Axonogenesis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Morphogenesis Axon Development Homeostasis Of Number Of Cells Positive Regulation Of Protein Binding Cell Morphogenesis Involved In Neuron Differentiation Cell Development Developmental Process Actin Cytoskeleton Organization Execution Phase Of Apoptosis Neuron Projection Morphogenesis Actin Filament-based Process Regulation Of Cellular Component Organization System Development Cell Morphogenesis Involved In Differentiation Organelle Organization Erythrocyte Differentiation Regulation Of Actin Cytoskeleton Organization Erythrocyte Homeostasis Neuron Projection Development Multicellular Organismal Development Positive Regulation Of Binding Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Filament-based Process Anatomical Structure Development Anatomical Structure Morphogenesis Myeloid Cell Homeostasis Regulation Of Protein Binding
Tagcloud ?		antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1	ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 ugt1a1
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb41 epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1