PLCG2 and IRF8

		PLCG2	IRF8
Description		phospholipase C gamma 2	interferon regulatory factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Intracellular Vesicle	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphotyrosine Residue Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding Protein Tyrosine Kinase Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Activation Response To Yeast Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Follicular B Cell Differentiation Positive Regulation Of Dendritic Cell Cytokine Production Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Phospholipid Catabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Programmed Cell Death Lipid Catabolic Process Wnt Signaling Pathway Regulation Of Lipid Metabolic Process Calcium-mediated Signaling Platelet Activation B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Negative Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Calcium Ion Cellular Response To Lipid Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Lectin	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Germinal Center B Cell Differentiation Follicular B Cell Differentiation Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Response To Bacterium Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Dendritic Cell Differentiation Defense Response To Other Organism
Pathways		GPVI-mediated activation cascade Toll Like Receptor 4 (TLR4) Cascade Synthesis of IP3 and IP4 in the cytosol Generation of second messenger molecules Role of phospholipids in phagocytosis DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Erythropoietin activates Phospholipase C gamma (PLCG) FCGR3A-mediated IL10 synthesis Potential therapeutics for SARS Signaling by CSF1 (M-CSF) in myeloid cells Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Alzheimer's disease ( 34099642) Alzheimer's disease (late onset) ( 28714976) Blood protein levels ( 30072576) Breast cancer (menopausal hormone therapy interaction) ( 24080446) Ceramide levels (C24:0) ( 32489964) Chronic widespread musculoskeletal pain ( 33331911) Coronary artery disease ( 33020668 29212778) Dental caries (decayed, missing and filled teeth) ( 31533690) Height ( 28552196) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 33031748) Takayasu arteritis ( 33308445) Ulcerative colitis ( 28067908) Upper eyelid morphology ( 29921221) Venous thromboembolism ( 31420334 31676865) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Aspartate aminotransferase levels ( 33547301) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Behcet's disease ( 33393726) Chronic lymphocytic leukemia ( 21131588 24292274 28165464 23770605 26956414) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Diabetic retinopathy ( 21441570) Gestational age at birth (maternal effect) ( 27490719) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233) Limited cutaneous systemic scleroderma ( 29293537) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23857890) Major depressive disorder x sex interaction ( 34099189) Monocyte count ( 27863252 32888494 23314186 28193307 29403010) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244 19525953 24076602 21833088) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 24390342 23143596 22446963 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Severe insulin-deficient type 2 diabetes ( 34737425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26663301 26502338 33272962 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020) Ulcerative colitis ( 32072174 23511034)
Interacting Genes		56 interacting genes: AR ASB9 BLK BLNK BTK CBLB CD19 DAPP1 EGFR ELK1 EPOR EPYC ERBB2 ERBB3 ERBB4 ESD FCER1G FLT1 FYN GAB1 GAB2 GABPB2 HCK HSPD1 IRS1 ISL1 ITK JAK1 JAK2 KCTD17 KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LHX8 LIME1 LYN MET NPM1 PRKD1 PTPN6 PTTG1 RALBP1 RTL10 SETD9 SH3BP2 SHC1 SYK TEC TP53 TWIST2 ZKSCAN7 ZNF512B	12 interacting genes: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17
Entrez ID		5336	3394
HPRD ID		02570	03336
Ensembl ID		ENSG00000197943	ENSG00000140968
Uniprot IDs		P16885	H3BRT4 Q02556
PDB IDs		2K2J 2W2W 2W2X 8JQG 8JQH 8JQI 8T7C
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-activating Signaling Pathway B Cell Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Activation Of Immune Response Protein Kinase Activity Signal Transduction Lymphocyte Activation Leukocyte Activation Protein Phosphorylation Positive Regulation Of Immune Response Intracellular Signal Transduction Kinase Activity Phosphorylation SH2 Domain Binding Cell Activation Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Raft Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Immune System Process Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway T Cell Activation Cellular Developmental Process Immune Effector Process Leukocyte Proliferation Regulation Of Immune System Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process ATP Binding Positive Regulation Of MAPK Cascade Adaptive Immune Response Protein Autophosphorylation	Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-12 Production Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Canonical NF-kappaB Signal Transduction NF-kappaB P50/p65 Complex DNA-templated Transcription Regulation Of Innate Immune Response Response To Virus Negative Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Non-canonical NF-kappaB Signal Transduction Follicular B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of RNA Metabolic Process Defense Response To Virus Toll-like Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Cytokine Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Defense Response Cellular Response To Nicotine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Metabolic Process Defense Response To Tumor Cell Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response Cytokine-mediated Signaling Pathway Defense Response Antiviral Innate Immune Response Actinin Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Positive Regulation Of Type I Interferon Production Sequence-specific DNA Binding Immune System Process Positive Regulation Of Defense Response Cellular Response To Lipid
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?