IRF7 and CDK4

		IRF7	CDK4
Description		interferon regulatory factor 7	cyclin dependent kinase 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Bicellular Tight Junction Membrane Nuclear Membrane Cyclin D1-CDK4 Complex Cyclin D2-CDK4 Complex Cyclin D3-CDK4 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Response To Virus Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	G1/S Transition Of Mitotic Cell Cycle Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Cell Cycle Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Meiotic recombination Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs			Purvalanol Alvocidib Palbociclib Ribociclib Abemaciclib Fostamatinib Trilaciclib
Diseases			Malignant melanoma Glioma Cervical cancer
GWAS		Systemic lupus erythematosus ( 26502338 27399966 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)	Brain morphology (MOSTest) ( 32665545) Celiac disease or Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		27 interacting genes: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B	136 interacting genes: AGAP2 AKT1 ANKRD12 ANXA7 APLP1 APP ARAF ARID4A ARNT ATP5F1B BAG6 BCL11A BECN1 BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 CNTN2 DAZAP2 DDAH2 DUSP9 EIF4EBP2 EPHA2 ERBB2 FARP2 FBXO8 FGFR4 FOXM1 FZR1 GLIS2 GRM1 H1-0 H1-1 H1-3 HGF HIF1A HMGXB3 HOOK1 HSP90AB1 IFI27 IGF1R IKZF3 IL15RA INCA1 KDELR2 LATS2 LNX2 LUC7L2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MAPRE2 MARCKS MCM2 MDM4 MET MYOD1 MZF1 NCOA2 NF2 NOL12 OGDHL ORC3 OTX2 PDGFRA PGD PIAS1 PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS1 RAF1 RASSF1 RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA SPOP STK11 STUB1 TEAD2 TERT TGFBR1 TK1 TP53 TRMT2A TSC1 TSPYL2 UBE3A UBTF UHRF2 USP17L2 USP51 VTA1 WDR33 YBX3 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655
Entrez ID		3665	1019
HPRD ID		05441	00447
Ensembl ID		ENSG00000185507	ENSG00000135446
Uniprot IDs		B4E1B1 M9RSF4 Q92985	P11802
PDB IDs		2O61	2W96 2W99 2W9F 2W9Z 3G33 5FWK 5FWL 5FWM 5FWP 6P8E 6P8F 6P8G 6P8H 7SJ3
Enriched GO Terms of Interacting Partners?		Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Lipopolysaccharide-mediated Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Transferase Activity Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cellular Response To Molecule Of Bacterial Origin Acetyltransferase Activity Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response Canonical NF-kappaB Signal Transduction MRNA Transcription Macromolecule Metabolic Process Transcription Coregulator Activity Positive Regulation Of Immune Response Histone Acetyltransferase Complex Intracellular Receptor Signaling Pathway Protein-lysine-acetyltransferase Activity Positive Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway	Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Cell Population Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Kinase Activity Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Phosphorylation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleoplasm Negative Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process Cellular Response To Stress Protein Kinase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process
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