IRAK2 and IRAK1

Number of citations of the paper that reports this interaction (PubMedID 10383454)
0

Data Source:
HPRD (in vivo)

		IRAK2	IRAK1
Description		interleukin 1 receptor associated kinase 2	interleukin 1 receptor associated kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane	Nucleus Nucleoplasm Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Signaling Adaptor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction Toll Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Toll Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs			Fostamatinib
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Sum eosinophil basophil counts ( 27863252)	Celiac disease ( 22057235) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24390342 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 19838195 26502338 26606652 26663301 33272962)
Interacting Genes		20 interacting genes: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A	52 interacting genes: AKT1 BCL10 BTK CCDC47 FADD H3-4 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 OPTN PELI1 PELI2 PELI3 PPP1CC PPP3CB PRDX1 PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 STING1 SUMO1 TAB2 TBKBP1 TICAM2 TIFA TLR2 TLR4 TOLLIP TRAF4 TRAF6 TRIM32 USP20 YTHDC2
Entrez ID		3656	3654
HPRD ID		04491	02235
Ensembl ID		ENSG00000134070	ENSG00000184216
Uniprot IDs		O43187	D3YTB5 P51617
PDB IDs		3MOP	6BFN
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune Response Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of Gene Expression Positive Regulation Of Cytokine Production Regulation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Response To External Biotic Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cell Communication Immune Response-regulating Signaling Pathway Positive Regulation Of Signaling Regulation Of Defense Response Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Other Organism Activation Of Immune Response Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Immune System Process Positive Regulation Of Metabolic Process Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Defense Response To Other Organism Defense Response Response To Lipid Regulation Of Type I Interferon Production Innate Immune Response	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Signaling Pathway Immune System Process Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Defense Response Regulation Of Innate Immune Response Response To External Biotic Stimulus Cell Surface Toll-like Receptor Signaling Pathway Response To Other Organism Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Toll-like Receptor 4 Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Positive Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Immune Response Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cytokine Production Signal Transduction Intracellular Signaling Cassette Signaling Adaptor Activity Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Signaling Regulation Of Cell Communication
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