IRAK2 and MYD88

Number of citations of the paper that reports this interaction (PMID 9374458)
178

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		IRAK2	MYD88
Gene Name		interleukin-1 receptor-associated kinase 2	myeloid differentiation primary response 88
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane Interleukin-1 Receptor Complex	Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Death Receptor Binding Protein Binding Identical Protein Binding TIR Domain Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Mechanical Stimulus
Pathways		IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex	p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A	39 interactors: BTK CD93 CISH FADD FLII IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 PELI2 PFKL POLR1C PRDX1 RAC1 SARM1 SIAH1 SIAH2 SMAD3 SPOP STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7
Entrez ID		3656	4615
HPRD ID		04491	03703
Ensembl ID		ENSG00000134070	ENSG00000172936
Uniprot IDs		O43187	J3KPU4 J3KQ87 J3KQJ6 Q99836
PDB IDs		3MOP	2JS7 2Z5V 3MOP 4DOM 4EO7
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Lipopolysaccharide Response To Bacterium Regulation Of Interleukin-6 Production Regulation Of Immune System Process Response To Molecule Of Bacterial Origin Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cellular Response To Molecule Of Bacterial Origin Toll Signaling Pathway Immune Response Response To Other Organism Defense Response Interleukin-1-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Biotic Stimulus Regulation Of Cytokine Production Positive Regulation Of Intracellular Signal Transduction Response To Lipid Regulation Of Signaling Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Signal Transduction Immune System Process Toll-like Receptor 9 Signaling Pathway Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Lipopolysaccharide Signal Transduction	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Defense Response Regulation Of Cytokine Production Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Interferon-beta Production Response To Other Organism I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Regulation Of Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Biotic Stimulus Toll-like Receptor 2 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Regulation Of Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of Interferon-beta Production Regulation Of Intracellular Signal Transduction Response To External Stimulus Inflammatory Response Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Chemokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Interferon-alpha Production Regulation Of Protein Metabolic Process Signal Transduction Response To Stimulus Regulation Of Chemokine Production
Tagcloud ?		adapter bmdm bmdms catalytically corrected d359a e525a hardly il10 il6 irak1 knock limiting modest myd88 pdcs plasmacytoid secretion sustain tlr tlr4 tlr7 tlr9 tnfa tnfr toll traf6 trif	binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Difference) ?		adapter bmdm bmdms catalytically corrected d359a e525a hardly il10 il6 irak1 knock limiting modest pdcs plasmacytoid secretion sustain tlr tlr4 tlr7 tlr9 tnfa tnfr toll traf6 trif	binet biology birc3 briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Intersection) ?		myd88