IRAK2 and SARM1

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		IRAK2	SARM1
Gene Name		interleukin-1 receptor-associated kinase 2	sterile alpha and TIR motif containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane Interleukin-1 Receptor Complex	Cytoplasm Mitochondrion Cytosol Microtubule Cell Junction Axon Dendrite Extrinsic Component Of Mitochondrial Outer Membrane Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Activation Of MAPK Activity Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Glucose Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Dendrite Morphogenesis Regulation Of Neuron Death
Pathways		IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A	7 interactors: CCDC47 GHITM IRAK2 MYD88 NLRX1 STT3A TICAM2
Entrez ID		3656	23098
HPRD ID		04491	09664
Ensembl ID		ENSG00000134070	ENSG00000004139
Uniprot IDs		O43187	Q05B42 Q0D2N8 Q6SZW1
PDB IDs		3MOP
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Lipopolysaccharide Response To Bacterium Regulation Of Interleukin-6 Production Regulation Of Immune System Process Response To Molecule Of Bacterial Origin Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cellular Response To Molecule Of Bacterial Origin Toll Signaling Pathway Immune Response Response To Other Organism Defense Response Interleukin-1-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Biotic Stimulus Regulation Of Cytokine Production Positive Regulation Of Intracellular Signal Transduction Response To Lipid Regulation Of Signaling Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Signal Transduction Immune System Process Toll-like Receptor 9 Signaling Pathway Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Lipopolysaccharide Signal Transduction	Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Biotic Stimulus Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Chemokine Production Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Chemokine Production I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipid Inflammatory Response Immune Response-regulating Signaling Pathway Response To Interleukin-1 Immune Response Regulation Of Immune System Process JNK Cascade Response To Bacterium Positive Regulation Of Interleukin-18-mediated Signaling Pathway Defense Response Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Co-translational Protein Modification Positive Regulation Of Immune Response
Tagcloud ?		adapter bmdm bmdms catalytically corrected d359a e525a hardly il10 il6 irak1 knock limiting modest myd88 pdcs plasmacytoid secretion sustain tlr tlr4 tlr7 tlr9 tnfa tnfr toll traf6 trif	affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic tlr toll
Tagcloud (Difference) ?		adapter bmdm bmdms catalytically corrected d359a e525a hardly il10 il6 irak1 knock limiting modest myd88 pdcs plasmacytoid secretion sustain tlr4 tlr7 tlr9 tnfa tnfr traf6 trif	affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic
Tagcloud (Intersection) ?		tlr toll