IRAK2 and SARM1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		IRAK2	SARM1
Description		interleukin 1 receptor associated kinase 2	sterile alpha and TIR motif containing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Cell Surface Microtubule Cytoskeleton Axon Dendrite Neuromuscular Junction Protein-containing Complex Cell Projection Synapse Glutamatergic Synapse Extrinsic Component Of Synaptic Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Signaling Adaptor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity	NAD+ Nucleosidase Activity Protein Binding Hydrolase Activity Signaling Adaptor Activity Identical Protein Binding NADP+ Nucleosidase Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction Toll Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Immune System Process Signal Transduction Nervous System Development Response To Glucose NAD+ Catabolic Process Cell Differentiation Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Axon Injury Regulation Of Dendrite Morphogenesis Nervous System Process Protein Localization To Mitochondrion Modification Of Postsynaptic Structure Regulation Of Synapse Pruning
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Sum eosinophil basophil counts ( 27863252)	Amyotrophic lateral sclerosis ( 27455348) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Osteoprotegerin levels ( 25080503)
Interacting Genes		20 interacting genes: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A	6 interacting genes: CCDC47 IRAK2 MYD88 NLRX1 STT3A TICAM2
Entrez ID		3656	23098
HPRD ID		04491	09664
Ensembl ID		ENSG00000134070	ENSG00000004139
Uniprot IDs		O43187	Q05B42 Q0D2N8 Q6SZW1
PDB IDs		3MOP	6O0Q 6O0R 6O0S 6O0T 6O0U 6O0V 6O1B 6QWV 6WPK 6ZFX 6ZG0 6ZG1 7ANW 7CM5 7CM6 7CM7 7DJT 7KNQ 7LD0 7NAG 7NAH 7NAI 7NAJ 7NAK 7NAL 7QG0 8D0C 8D0D 8D0E 8D0F 8D0G 8D0H 8D0I 8D0J 8GNI 8GNJ 8GQ5 8P2L 9L2D 9L2E
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune Response Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of Gene Expression Positive Regulation Of Cytokine Production Regulation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Response To External Biotic Stimulus Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cell Communication Immune Response-regulating Signaling Pathway Positive Regulation Of Signaling Regulation Of Defense Response Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Other Organism Activation Of Immune Response Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Immune System Process Positive Regulation Of Metabolic Process Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Defense Response To Other Organism Defense Response Response To Lipid Regulation Of Type I Interferon Production Innate Immune Response	Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Toll Signaling Pathway Signaling Adaptor Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Regulation Of Type I Interferon Production MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Molecular Adaptor Activity Activation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Macrophage Cytokine Production Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Endosome Membrane Positive Regulation Of Innate Immune Response Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Chemokine Production Activation Of Immune Response Response To Interleukin-1 Positive Regulation Of Defense Response TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Positive Regulation Of Type I Interferon Production Phagocytosis Negative Regulation Of Canonical NF-kappaB Signal Transduction Defense Response Regulation Of Chemokine Production Inflammatory Response Oligosaccharyl Transferase Activity Toll-like Receptor 5 Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Regulation Of Immune System Process Response To Stress Innate Immune Response Toll-like Receptor 8 Signaling Pathway
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