FNTA and KRAS

Number of citations of the paper that reports this interaction (PMID 12374986)
31

Data Source:
HPRD (in vitro)

		FNTA	KRAS
Gene Name		farnesyltransferase, CAAX box, alpha	Kirsten rat sarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Cytoplasm Mitochondrion Cytosol Plasma Membrane Focal Adhesion Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft
	Molecular Function	Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Acetylcholine Receptor Regulator Activity Receptor Tyrosine Kinase Binding Alpha-tubulin Binding	Protein Binding GTP Binding GMP Binding GDP Binding LRR Domain Binding Protein Complex Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Transforming Growth Factor Beta Receptor Signaling Pathway Phototransduction, Visible Light Regulation Of Receptor Activity Rhodopsin Mediated Signaling Pathway Protein Farnesylation Protein Geranylgeranylation Regulation Of Rhodopsin Mediated Signaling Pathway Neurotransmitter Receptor Metabolic Process Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Deacetylase Activity	MAPK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Social Behavior Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Leukocyte Migration Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Glucocorticoid Response To Mineralocorticoid Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Apoptotic cleavage of cellular proteins Visual phototransduction The phototransduction cascade Programmed Cell Death Apoptotic execution phase Diseases associated with visual transduction	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ACVR1 CENPF FNTB GBP1 HDAC6 HRAS INHBB KRAS PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	35 interactors: ADH6 APP ARAF BCL2 CALM1 CCT7 DDX47 DDX50 DNAJA3 EEF1A1 EGLN1 EPB42 FNTA FNTB HNRNPC IGSF21 LPAR1 MDFI PDE4DIP PGGT1B PIK3CA PIK3CG PIK3R2 PSMA3 RAF1 RALGDS RAP1GDS1 RASGRF2 RASGRP2 RASSF2 RASSF5 RBPMS RGL2 SHOC2 ZDHHC17
Entrez ID		2339	3845
HPRD ID		00607	01817
Ensembl ID		ENSG00000168522	ENSG00000133703
Uniprot IDs		P49354	L7RSL8 P01116
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	1D8D 1D8E 1KZO 1KZP 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Death Response To Stress Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Response To External Stimulus Defense Response Positive Regulation Of Programmed Cell Death Response To Growth Factor Pathway-restricted SMAD Protein Phosphorylation Wound Healing Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Wounding Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Innate Immune Response Activin Receptor Signaling Pathway Locomotion Cell Migration Positive Regulation Of Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Rac Protein Signal Transduction Cellular Response To Stimulus Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Response To Stimulus Cell Communication Blood Coagulation Tube Morphogenesis Hemostasis Branching Morphogenesis Of An Epithelial Tube Regulation Of Intracellular Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Activation Of MAPKK Activity Cell Development	Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Cell Communication Response To Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Platelet Activation Response To Wounding Positive Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Programmed Cell Death Positive Regulation Of Hydrolase Activity Regulation Of Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Death Death Protein Prenylation Wound Healing Blood Coagulation Small GTPase Mediated Signal Transduction Hemostasis Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process
Tagcloud ?		21q11 8p11 aberration cbl comprehensively constitutional ct8m gained golga7 harbouring ikbkb jmml juvenile leukaemia leukaemogenesis malignancies mir486 monosomy mosaic mosaicisms myelomonocytic myst3 nf1 nras ptpn11 smallest submicroscopic trisomy ube2v2	bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus
Tagcloud (Difference) ?		21q11 8p11 aberration cbl comprehensively constitutional ct8m gained golga7 harbouring ikbkb jmml juvenile leukaemia leukaemogenesis malignancies mir486 monosomy mosaic mosaicisms myelomonocytic myst3 nf1 nras ptpn11 smallest submicroscopic trisomy ube2v2	bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus
Tagcloud (Intersection) ?