FNTA and RPL13A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FNTA	RPL13A
Description		farnesyltransferase, CAAX box, subunit alpha	ribosomal protein L13a
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GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse GAIT Complex Ribonucleoprotein Complex
	Molecular Function	Prenyltransferase Activity Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Protein Prenyltransferase Activity Acetyltransferase Activator Activity Transferase Activity Enzyme Binding Receptor Tyrosine Kinase Binding Alpha-tubulin Binding Molecular Adaptor Activity	RNA Binding MRNA Binding Structural Constituent Of Ribosome
	Biological Process	Nuclear Envelope Organization Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Peptide Pheromone Maturation Neuromuscular Junction Development Protein Farnesylation Protein Geranylgeranylation Positive Regulation Of Rac Protein Signal Transduction Protein Maturation Regulation Of Microtubule-based Movement Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering	Cytoplasmic Translation Translation Regulation Of Translation Negative Regulation Of Translation Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Homeostatic Process Macrophage Chemotaxis Lung Morphogenesis Cellular Response To Type II Interferon Negative Regulation Of Formation Of Translation Preinitiation Complex
Pathways		Apoptotic cleavage of cellular proteins Inactivation, recovery and regulation of the phototransduction cascade RAS processing Potential therapeutics for SARS	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		AZD3409 Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE	(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases
GWAS		Zinc levels ( 26025379)	Hematological and biochemical traits ( 20139978) Monocyte count ( 32888494)
Interacting Genes		22 interacting genes: ACVR1 AP4M1 CENPF CFTR FNTB GBP1 GRSF1 HDAC6 HRAS INHBB KRAS OGT PGGT1B PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	15 interacting genes: ALDH2 ALG12 CALM1 CRP CYP2E1 ETS1 FBH1 FILNC1 FNTA GOLM1 MT-ND1 NOD2 PTEN STOM VTN
Entrez ID		2339	23521
HPRD ID		00607	11775
Ensembl ID		ENSG00000168522	ENSG00000142541
Uniprot IDs		P49354	A0A384ME37 P40429 Q8J015
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Anatomical Structure Morphogenesis Tissue Morphogenesis Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction GDP Binding Morphogenesis Of An Epithelium Response To Cholesterol Protein Localization To Vacuole Activin Receptor Signaling Pathway Regulation Of Protein Localization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity, Type I Protein Prenyltransferase Activity Response To Alcohol Positive Regulation Of Developmental Process Positive Regulation Of SMAD Protein Signal Transduction Non-canonical Inflammasome Complex Assembly Myofibroblast Differentiation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Tube Morphogenesis Activin Receptor Complex Activin Receptor Activity, Type I Regulation Of Enamel Mineralization Positive Regulation Of Mesenchymal Stem Cell Proliferation Developmental Process Morphogenesis Of A Branching Epithelium Regulation Of Establishment Of Protein Localization Response To Lipid Regulation Of Protein Localization To Cell Periphery Regulation Of Programmed Cell Death Germ Cell Migration Morphogenesis Of A Branching Structure Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cell Migration Protein Prenylation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Developmental Process Prenyltransferase Activity Regulation Of Protein Localization To Membrane
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