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FNTA and RHOB
Number of citations of the paper that reports this interaction (PubMedID
1400319
)
0
Data Source:
HPRD
(in vitro)
FNTA
RHOB
Description
farnesyltransferase, CAAX box, subunit alpha
ras homolog family member B
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Microtubule Associated Complex
Plasma Membrane
CAAX-protein Geranylgeranyltransferase Complex
Protein Farnesyltransferase Complex
Nucleus
Endosome
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Focal Adhesion
Endosome Membrane
Membrane
Late Endosome Membrane
Cleavage Furrow
Synapse
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Molecular Function
Prenyltransferase Activity
Protein Farnesyltransferase Activity
Protein Geranylgeranyltransferase Activity
CAAX-protein Geranylgeranyltransferase Activity
Rab Geranylgeranyltransferase Activity
Protein Binding
Microtubule Binding
Protein Prenyltransferase Activity
Acetyltransferase Activator Activity
Transferase Activity
Enzyme Binding
Receptor Tyrosine Kinase Binding
Alpha-tubulin Binding
Molecular Adaptor Activity
Nucleotide Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Biological Process
Nuclear Envelope Organization
Enzyme-linked Receptor Protein Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Peptide Pheromone Maturation
Neuromuscular Junction Development
Protein Farnesylation
Protein Geranylgeranylation
Positive Regulation Of Rac Protein Signal Transduction
Protein Maturation
Regulation Of Microtubule-based Movement
Skeletal Muscle Acetylcholine-gated Channel Clustering
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Mitotic Cytokinesis
Angiogenesis
Intracellular Protein Transport
Apoptotic Process
Actin Filament Organization
Cell Adhesion
Signal Transduction
Small GTPase-mediated Signal Transduction
Rho Protein Signal Transduction
Endosome To Lysosome Transport
Positive Regulation Of Endothelial Cell Migration
Protein Transport
Cell Differentiation
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Positive Regulation Of Apoptotic Process
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Endothelial Tube Morphogenesis
Cellular Response To Hydrogen Peroxide
Cellular Response To Ionizing Radiation
Regulation Of Modification Of Postsynaptic Structure
Pathways
Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade
RAS processing
Potential therapeutics for SARS
GPVI-mediated activation cascade
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins
RHO GTPases Activate Rhotekin and Rhophilins
RHOB GTPase cycle
Drugs
AZD3409
Lonafarnib
2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE
(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
L-778123
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
Farnesyl diphosphate
Geranylgeranyl diphosphate
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Botulinum toxin type A
Diseases
GWAS
Zinc levels (
26025379
)
Systemic sclerosis (
21750679
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Interacting Genes
22 interacting genes:
ACVR1
AP4M1
CENPF
CFTR
FNTB
GBP1
GRSF1
HDAC6
HRAS
INHBB
KRAS
OGT
PGGT1B
PTP4A3
RHOB
RPL13A
SAFB2
STAT2
TGFB1
TGFBR1
TGM2
VAV2
18 interacting genes:
ARHGDIG
ARHGEF3
CIT
FNTA
MAP1A
NEDD4L
PDE6D
PGGT1B
PIAS1
PKN1
PPP2CA
RHPN2
ROCK1
RTKN
SMURF1
TNFAIP1
UBE2I
ZKSCAN5
Entrez ID
2339
388
HPRD ID
00607
01321
Ensembl ID
ENSG00000168522
ENSG00000143878
Uniprot IDs
P49354
P62745
PDB IDs
1JCQ
1LD7
1LD8
1MZC
1S63
1SA4
1TN6
2F0Y
2H6F
2H6G
2H6H
2H6I
2IEJ
3E37
2FV8
6HXU
6SGE
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Anatomical Structure Morphogenesis
Tissue Morphogenesis
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Positive Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
GDP Binding
Morphogenesis Of An Epithelium
Response To Cholesterol
Protein Localization To Vacuole
Activin Receptor Signaling Pathway
Regulation Of Protein Localization
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Multicellular Organismal Process
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Prenyltransferase Activity
Response To Alcohol
Positive Regulation Of Developmental Process
Positive Regulation Of SMAD Protein Signal Transduction
Non-canonical Inflammasome Complex Assembly
Myofibroblast Differentiation
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Tube Morphogenesis
Activin Receptor Complex
Activin Receptor Activity, Type I
Regulation Of Enamel Mineralization
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Developmental Process
Morphogenesis Of A Branching Epithelium
Regulation Of Establishment Of Protein Localization
Response To Lipid
Regulation Of Protein Localization To Cell Periphery
Regulation Of Programmed Cell Death
Germ Cell Migration
Morphogenesis Of A Branching Structure
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Positive Regulation Of Cell Migration
Protein Prenylation
Positive Regulation Of Cell Motility
Cellular Developmental Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Developmental Process
Prenyltransferase Activity
Regulation Of Protein Localization To Membrane
Rho Protein Signal Transduction
CAAX-protein Geranylgeranyltransferase Activity
CAAX-protein Geranylgeranyltransferase Complex
Protein Modification Process
Protein Geranylgeranyltransferase Activity
Cytosol
Protein Prenyltransferase Activity
Small GTPase Binding
Protein Geranylgeranylation
Tau Protein Binding
Protein Prenylation
Prenyltransferase Activity
Transferase Activity
Mitotic Cytokinesis
GTPase Inhibitor Activity
Cytoskeleton-dependent Cytokinesis
Regulation Of Intracellular Signal Transduction
Small GTPase-mediated Signal Transduction
Regulation Of Microtubule-based Process
SUMO Transferase Activity
Receptor Catabolic Process
Positive Regulation Of Dendrite Extension
Regulation Of Cytoskeleton Organization
Post-translational Protein Modification
Actomyosin Structure Organization
Renal System Process
Negative Regulation Of Hippo Signaling
Apoptotic Process
Cytoplasm
Regulation Of Protein Localization
Cell Death
Programmed Cell Death
Presynaptic Cytosol
Postsynaptic Cytosol
Cortical Actin Cytoskeleton Organization
Regulation Of Cell Communication
Regulation Of Signaling
Protein Metabolic Process
Epithelial Cell Migration
Regulation Of Signal Transduction
Signal Transduction
System Process
Neuromuscular Junction Development
Microtubule Associated Complex
Regulation Of Microtubule Cytoskeleton Organization
Regulation Of Protein Localization To Cell Surface
Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Regulation Of Supramolecular Fiber Organization
Protein Modification By Small Protein Conjugation
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Tagcloud (Intersection)
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