FNTA and FNTB

Number of citations of the paper that reports this interaction (PMID 12036349)
3

Data Source:
HPRD (in vitro)

		FNTA	FNTB
Gene Name		farnesyltransferase, CAAX box, alpha	farnesyltransferase, CAAX box, beta
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex
	Molecular Function	Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Acetylcholine Receptor Regulator Activity Receptor Tyrosine Kinase Binding Alpha-tubulin Binding	Farnesyltranstransferase Activity Protein Farnesyltransferase Activity Protein Binding Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Transforming Growth Factor Beta Receptor Signaling Pathway Phototransduction, Visible Light Regulation Of Receptor Activity Rhodopsin Mediated Signaling Pathway Protein Farnesylation Protein Geranylgeranylation Regulation Of Rhodopsin Mediated Signaling Pathway Neurotransmitter Receptor Metabolic Process Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Deacetylase Activity	Phototransduction, Visible Light Negative Regulation Of Cell Proliferation Response To Inorganic Substance Response To Organic Cyclic Compound Rhodopsin Mediated Signaling Pathway Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway Response To Cytokine Wound Healing Positive Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Apoptotic cleavage of cellular proteins Visual phototransduction The phototransduction cascade Programmed Cell Death Apoptotic execution phase Diseases associated with visual transduction	Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs
Diseases
GWAS			Blood trace element (Zn levels) ( 23720494) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		17 interactors: ACVR1 CENPF FNTB GBP1 HDAC6 HRAS INHBB KRAS PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	9 interactors: CENPF FNTA GBP1 HDAC6 HRAS KRAS PTP4A3 RAP2A RRAS2
Entrez ID		2339	2342
HPRD ID		00607	00608
Ensembl ID		ENSG00000168522	ENSG00000257365
Uniprot IDs		P49354	P49356
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Death Response To Stress Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Response To External Stimulus Defense Response Positive Regulation Of Programmed Cell Death Response To Growth Factor Pathway-restricted SMAD Protein Phosphorylation Wound Healing Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Wounding Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Innate Immune Response Activin Receptor Signaling Pathway Locomotion Cell Migration Positive Regulation Of Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Rac Protein Signal Transduction Cellular Response To Stimulus Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Response To Stimulus Cell Communication Blood Coagulation Tube Morphogenesis Hemostasis Branching Morphogenesis Of An Epithelial Tube Regulation Of Intracellular Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Activation Of MAPKK Activity Cell Development	Ras Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Migration Response To Growth Factor Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Locomotion Regulation Of Synaptic Transmission, GABAergic Regulation Of Cellular Component Movement Regulation Of Rac Protein Signal Transduction Social Behavior Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Neuron Death Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Light Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Response To External Stimulus Positive Regulation Of Locomotion Visual Behavior Activation Of MAPKK Activity Lung Morphogenesis Cellular Response To Organic Substance Regulation Of Oxidoreductase Activity Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Associative Learning Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Muscle Structure Development Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Receptor Activity Cell Communication Cellular Response To Growth Factor Stimulus Response To Organic Substance Learning Actin Cytoskeleton Organization
Tagcloud ?		21q11 8p11 aberration cbl comprehensively constitutional ct8m gained golga7 harbouring ikbkb jmml juvenile leukaemia leukaemogenesis malignancies mir486 monosomy mosaic mosaicisms myelomonocytic myst3 nf1 nras ptpn11 smallest submicroscopic trisomy ube2v2	annotation atad5 automatically becn1 cdkn2a centered clusterone cytoscape david e2f e2f1 geneways kegg kras language module modules mp neurofibromatosis nf1 nf2 nsclc orthologous phenotypes proven successively systemically thyroglobulin visualization
Tagcloud (Difference) ?		21q11 8p11 aberration cbl comprehensively constitutional ct8m gained golga7 harbouring ikbkb jmml juvenile leukaemia leukaemogenesis malignancies mir486 monosomy mosaic mosaicisms myelomonocytic myst3 nras ptpn11 smallest submicroscopic trisomy ube2v2	annotation atad5 automatically becn1 cdkn2a centered clusterone cytoscape david e2f e2f1 geneways kegg kras language module modules mp neurofibromatosis nf2 nsclc orthologous phenotypes proven successively systemically thyroglobulin visualization
Tagcloud (Intersection) ?		nf1