FNTA and CENPF

Number of citations of the paper that reports this interaction (PMID 10852915)
47

Data Source:
HPRD (in vitro)

		FNTA	CENPF
Gene Name		farnesyltransferase, CAAX box, alpha	centromere protein F, 350/400kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Spindle Cytosol Nuclear Matrix Midbody Pronucleus Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Acetylcholine Receptor Regulator Activity Receptor Tyrosine Kinase Binding Alpha-tubulin Binding	Chromatin Binding Protein Binding Protein C-terminus Binding Transcription Factor Binding Protein Homodimerization Activity Dynein Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Transforming Growth Factor Beta Receptor Signaling Pathway Phototransduction, Visible Light Regulation Of Receptor Activity Rhodopsin Mediated Signaling Pathway Protein Farnesylation Protein Geranylgeranylation Regulation Of Rhodopsin Mediated Signaling Pathway Neurotransmitter Receptor Metabolic Process Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Deacetylase Activity	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Muscle Organ Development Cell Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Cell Differentiation Response To Drug Negative Regulation Of Transcription, DNA-templated Cell Division Metaphase Plate Congression Kinetochore Assembly Regulation Of Cell Cycle DNA Biosynthetic Process
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Apoptotic cleavage of cellular proteins Visual phototransduction The phototransduction cascade Programmed Cell Death Apoptotic execution phase Diseases associated with visual transduction	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion G2/M Transition Mitotic Anaphase Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Polo-like kinase mediated events Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Response to antineoplastic agents ( 21659360)
Protein-Protein Interactions		17 interactors: ACVR1 CENPF FNTB GBP1 HDAC6 HRAS INHBB KRAS PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	10 interactors: BRAP CENPE CHMP2B FNTA FNTB NDEL1 NUP133 SNAP25 SVIL TOP3B
Entrez ID		2339	1063
HPRD ID		00607	02582
Ensembl ID		ENSG00000168522	ENSG00000117724
Uniprot IDs		P49354	P49454
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Death Response To Stress Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Response To External Stimulus Defense Response Positive Regulation Of Programmed Cell Death Response To Growth Factor Pathway-restricted SMAD Protein Phosphorylation Wound Healing Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Wounding Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Innate Immune Response Activin Receptor Signaling Pathway Locomotion Cell Migration Positive Regulation Of Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Rac Protein Signal Transduction Cellular Response To Stimulus Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Response To Stimulus Cell Communication Blood Coagulation Tube Morphogenesis Hemostasis Branching Morphogenesis Of An Epithelial Tube Regulation Of Intracellular Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Activation Of MAPKK Activity Cell Development	Establishment Of Chromosome Localization Protein Farnesylation Chromosome Segregation Establishment Of Organelle Localization Nucleus Organization Protein Prenylation Organelle Localization Regulation Of Cell Cycle Regulation Of Rhodopsin Mediated Signaling Pathway Mitotic Metaphase Plate Congression Organelle Organization Rhodopsin Mediated Signaling Pathway Metaphase Plate Congression Nuclear Envelope Disassembly Mitotic Cell Cycle Process Regulation Of Cell Division Mitotic Cell Cycle Positive Regulation Of Cell Cycle Mitotic Nuclear Division Membrane Organization Nuclear Envelope Organization Cellular Protein Complex Assembly Positive Regulation Of Tubulin Deacetylation Phototransduction, Visible Light Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Establishment Of Localization In Cell Detection Of Light Stimulus Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Mitotic Chromosome Movement Towards Spindle Pole Cellular Response To Radiation Cell Cycle Wound Healing Cellular Localization Cellular Macromolecular Complex Assembly Regulation Of Tubulin Deacetylation Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Positive Regulation Of Axon Regeneration Positive Regulation Of Deacetylase Activity Response To Wounding Retrograde Axon Cargo Transport Viral Budding Via Host ESCRT Complex Viral Life Cycle
Tagcloud ?		21q11 8p11 aberration cbl comprehensively constitutional ct8m gained golga7 harbouring ikbkb jmml juvenile leukaemia leukaemogenesis malignancies mir486 monosomy mosaic mosaicisms myelomonocytic myst3 nf1 nras ptpn11 smallest submicroscopic trisomy ube2v2	assembled causal computational coordinated cross drivers engineered foxm1 genetically genome indicator interactomes interrogation malignancy master networks profiles promote prostate regulators regulatory represents robust shows synergistic synergistically validation valuable wide
Tagcloud (Difference) ?		21q11 8p11 aberration cbl comprehensively constitutional ct8m gained golga7 harbouring ikbkb jmml juvenile leukaemia leukaemogenesis malignancies mir486 monosomy mosaic mosaicisms myelomonocytic myst3 nf1 nras ptpn11 smallest submicroscopic trisomy ube2v2	assembled causal computational coordinated cross drivers engineered foxm1 genetically genome indicator interactomes interrogation malignancy master networks profiles promote prostate regulators regulatory represents robust shows synergistic synergistically validation valuable wide
Tagcloud (Intersection) ?