FNTA and SAFB2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FNTA	SAFB2
Description		farnesyltransferase, CAAX box, subunit alpha	scaffold attachment factor B2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body Extracellular Exosome
	Molecular Function	Prenyltransferase Activity Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Protein Prenyltransferase Activity Acetyltransferase Activator Activity Transferase Activity Enzyme Binding Receptor Tyrosine Kinase Binding Alpha-tubulin Binding Molecular Adaptor Activity	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding
	Biological Process	Nuclear Envelope Organization Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Peptide Pheromone Maturation Neuromuscular Junction Development Protein Farnesylation Protein Geranylgeranylation Positive Regulation Of Rac Protein Signal Transduction Protein Maturation Regulation Of Microtubule-based Movement Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering	Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Processing Sertoli Cell Differentiation Regulation Of Androgen Receptor Signaling Pathway
Pathways		Apoptotic cleavage of cellular proteins Inactivation, recovery and regulation of the phototransduction cascade RAS processing Potential therapeutics for SARS
Drugs		AZD3409 Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Zinc levels ( 26025379)	Creativity ( 32133506) Obsessive-compulsive symptoms ( 26859814) vWF and FVIII levels ( 21810271)
Interacting Genes		22 interacting genes: ACVR1 AP4M1 CENPF CFTR FNTB GBP1 GRSF1 HDAC6 HRAS INHBB KRAS OGT PGGT1B PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	14 interacting genes: CEBPA CHGB ERBB2 ESR1 FNTA FUS FXR1 GIT2 RNF10 SAFB SIRPA SORBS3 SUMO2 ZSCAN18
Entrez ID		2339	9667
HPRD ID		00607	06424
Ensembl ID		ENSG00000168522	ENSG00000130254
Uniprot IDs		P49354	Q14151
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Anatomical Structure Morphogenesis Tissue Morphogenesis Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction GDP Binding Morphogenesis Of An Epithelium Response To Cholesterol Protein Localization To Vacuole Activin Receptor Signaling Pathway Regulation Of Protein Localization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity, Type I Protein Prenyltransferase Activity Response To Alcohol Positive Regulation Of Developmental Process Positive Regulation Of SMAD Protein Signal Transduction Non-canonical Inflammasome Complex Assembly Myofibroblast Differentiation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Tube Morphogenesis Activin Receptor Complex Activin Receptor Activity, Type I Regulation Of Enamel Mineralization Positive Regulation Of Mesenchymal Stem Cell Proliferation Developmental Process Morphogenesis Of A Branching Epithelium Regulation Of Establishment Of Protein Localization Response To Lipid Regulation Of Protein Localization To Cell Periphery Regulation Of Programmed Cell Death Germ Cell Migration Morphogenesis Of A Branching Structure Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cell Migration Protein Prenylation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Developmental Process Prenyltransferase Activity Regulation Of Protein Localization To Membrane	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Estrogen Receptor Signaling Pathway Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Inflammatory Response Neuromuscular Junction Development Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Molecular Condensate Scaffold Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Peptide Pheromone Maturation Presynapse Glutamatergic Synapse Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Cell Development Regulation Of Metabolic Process Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Vitamin B2 C/EBP Complex ERBB3:ERBB2 Complex Protein-containing Complex Localization CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Cellular Response To Interleukin-12 Negative Regulation Of Multicellular Organismal Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Metabolic Process
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