FNTA and GBP1

Number of citations of the paper that reports this interaction (PubMedID 11598000)
49

Data Source:
HPRD (in vitro)

		FNTA	GBP1
Description		farnesyltransferase, CAAX box, subunit alpha	guanylate binding protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Golgi Membrane Extracellular Region Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Symbiont Cell Surface
	Molecular Function	Prenyltransferase Activity Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Protein Prenyltransferase Activity Acetyltransferase Activator Activity Transferase Activity Enzyme Binding Receptor Tyrosine Kinase Binding Alpha-tubulin Binding Molecular Adaptor Activity	Nucleotide Binding Lipopolysaccharide Binding Actin Binding GTPase Activity G Protein Activity GDP Phosphatase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Enzyme Binding Cytokine Binding Spectrin Binding Identical Protein Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Nuclear Envelope Organization Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Peptide Pheromone Maturation Neuromuscular Junction Development Protein Farnesylation Protein Geranylgeranylation Positive Regulation Of Rac Protein Signal Transduction Protein Maturation Regulation Of Microtubule-based Movement Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering	Immune System Process Negative Regulation Of Interleukin-2 Production Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Protein Maturation Defense Response To Virus Cytolysis In Another Organism Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Protein Localization To Vacuole Positive Regulation Of Pyroptotic Inflammatory Response Non-canonical Inflammasome Complex Assembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Apoptotic cleavage of cellular proteins Inactivation, recovery and regulation of the phototransduction cascade RAS processing Potential therapeutics for SARS	Interferon gamma signaling CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity
Drugs		AZD3409 Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Zinc levels ( 26025379)	Remission after SSRI treatment in MDD or openness ( 29559929) Serum metabolite levels ( 33031748)
Interacting Genes		22 interacting genes: ACVR1 AP4M1 CENPF CFTR FNTB GBP1 GRSF1 HDAC6 HRAS INHBB KRAS OGT PGGT1B PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	2 interacting genes: FNTA FNTB
Entrez ID		2339	2633
HPRD ID		00607	02681
Ensembl ID		ENSG00000168522	ENSG00000117228
Uniprot IDs		P49354	P32455
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	1DG3 1F5N 2B8W 2B92 2BC9 2D4H 6K1Z 6K2D 6LOJ 8CQB 8Q4L 8R1A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Anatomical Structure Morphogenesis Tissue Morphogenesis Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction GDP Binding Morphogenesis Of An Epithelium Response To Cholesterol Protein Localization To Vacuole Activin Receptor Signaling Pathway Regulation Of Protein Localization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity, Type I Protein Prenyltransferase Activity Response To Alcohol Positive Regulation Of Developmental Process Positive Regulation Of SMAD Protein Signal Transduction Non-canonical Inflammasome Complex Assembly Myofibroblast Differentiation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Tube Morphogenesis Activin Receptor Complex Activin Receptor Activity, Type I Regulation Of Enamel Mineralization Positive Regulation Of Mesenchymal Stem Cell Proliferation Developmental Process Morphogenesis Of A Branching Epithelium Regulation Of Establishment Of Protein Localization Response To Lipid Regulation Of Protein Localization To Cell Periphery Regulation Of Programmed Cell Death Germ Cell Migration Morphogenesis Of A Branching Structure Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cell Migration Protein Prenylation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Developmental Process Prenyltransferase Activity Regulation Of Protein Localization To Membrane	Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Protein Prenyltransferase Activity Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Microtubule Associated Complex Regulation Of Microtubule-based Movement Peptide Pheromone Maturation CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Regulation Of Microtubule-based Process Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Protein Geranylgeranylation Enzyme Binding Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Nuclear Envelope Organization Negative Regulation Of RNA Splicing Peptide Binding Spinal Cord Development Regulation Of Rac Protein Signal Transduction MRNA Splice Site Recognition Neuromuscular Junction Development Alpha-tubulin Binding Receptor Clustering Cerebellum Development Receptor Tyrosine Kinase Binding Positive Regulation Of Small GTPase Mediated Signal Transduction
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