UBE2C and RNF167

Number of citations of the paper that reports this interaction (PubMedID 33650289)
0

Data Source:
BioGRID (pull down)

		UBE2C	RNF167
Description		ubiquitin conjugating enzyme E2 C	ring finger protein 167
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane	Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Organelle Membrane Endolysosome Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-like Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Exit From Mitosis Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Nutrient Levels Lysosome Localization Cellular Response To Amino Acid Starvation Protein K29-linked Ubiquitination Negative Regulation Of Cell Cycle Organelle Localization Regulation Of Synaptic Transmission, Glutamatergic Protein K63-linked Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 31562340)	Keratoconus ( 33649486) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		36 interacting genes: ANAPC11 ANAPC2 AURKA CDC20 CKAP2 CXCR1 DTX1 ENO2 HECTD3 ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 RAG1 RBX1 RELA RNF167 RNF31 RNF6 RNF7 RYR2 STUB1 TNNC1 TRIM13 TRIM2 TRIM21 TRIM28 TRIM29 UBA1 UBA6 UBASH3B UBC UBE3D	33 interacting genes: ACTA1 AFG3L2 ATP2A1 CAPN3 CDC34 EGFR GRIA2 MDK MYH7 PDCD1 PTN RAB7A SESN2 SLC67A1 SUMO1 TAFA2 TAFA5 TOLLIP TTN UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2G2 UBE2K UBE2N UBE2T UBE2W
Entrez ID		11065	26001
HPRD ID		05717	15261
Ensembl ID		ENSG00000175063	ENSG00000108523
Uniprot IDs		A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3	Q9H6Y7
PDB IDs		1I7K 4YII 5A31 5KHR 5L9U 8TAR 8TAU
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Catabolic Process Protein Polyubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Transferase Activity Protein Monoubiquitination Protein K48-linked Ubiquitination Macromolecule Metabolic Process Ubiquitin-ubiquitin Ligase Activity Cullin Family Protein Binding Protein K6-linked Ubiquitination Protein K63-linked Ubiquitination Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Autophagy Positive Regulation Of Catabolic Process Protein K29-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Zinc Ion Binding Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein K27-linked Ubiquitination Suppression Of Viral Release By Host SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Anaphase-promoting Complex Ubiquitin Activating Enzyme Activity Ubiquitin-like Protein Ligase Activity Anaphase-promoting Complex-dependent Catabolic Process	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation ATP Binding Protein Ubiquitination Protein K11-linked Ubiquitination Nucleotide Binding Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Catabolic Process Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein K6-linked Ubiquitination Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling DNA Metabolic Process Protein Autoubiquitination Cellular Response To Interferon-beta Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Negative Regulation Of TOR Signaling HULC Complex Response To Interferon-beta Regulation Of TORC1 Signaling Macromolecule Metabolic Process Postreplication Repair Skeletal Muscle Thin Filament Assembly DNA Repair Free Ubiquitin Chain Polymerization Positive Regulation Of Protein Modification Process Protein-containing Complex Regulation Of Protein Metabolic Process Leukocyte Chemotaxis Involved In Inflammatory Response DNA Damage Response Positive Regulation Of Post-translational Protein Modification
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