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UBE2C and CKAP2
Number of citations of the paper that reports this interaction (PubMedID
17339342
)
50
Data Source:
BioGRID
(enzymatic study)
UBE2C
CKAP2
Description
ubiquitin conjugating enzyme E2 C
cytoskeleton associated protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Spindle Pole
Nucleolus
Cytoplasm
Centrosome
Spindle
Cytoskeleton
Microtubule
Cilium
Microtubule Cytoskeleton
Ciliary Basal Body
Mitotic Spindle
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin-like Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Exit From Mitosis
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Mitotic Cytokinesis
Apoptotic Process
Negative Regulation Of Microtubule Depolymerization
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Height (
31562340
)
Interacting Genes
36 interacting genes:
ANAPC11
ANAPC2
AURKA
CDC20
CKAP2
CXCR1
DTX1
ENO2
HECTD3
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
RAG1
RBX1
RELA
RNF167
RNF31
RNF6
RNF7
RYR2
STUB1
TNNC1
TRIM13
TRIM2
TRIM21
TRIM28
TRIM29
UBA1
UBA6
UBASH3B
UBC
UBE3D
7 interacting genes:
AGR2
FBXO7
LRRK1
SREK1
TTC3
UBE2C
YWHAG
Entrez ID
11065
26586
HPRD ID
05717
10832
Ensembl ID
ENSG00000175063
ENSG00000136108
Uniprot IDs
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
Q8WWK9
PDB IDs
1I7K
4YII
5A31
5KHR
5L9U
8TAR
8TAU
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Ubiquitin Protein Ligase Activity
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis
Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Protein Modification Process
Catabolic Process
Protein Polyubiquitination
Protein Metabolic Process
Ubiquitin Protein Ligase Binding
Protein Autoubiquitination
Transferase Activity
Protein Monoubiquitination
Protein K48-linked Ubiquitination
Macromolecule Metabolic Process
Ubiquitin-ubiquitin Ligase Activity
Cullin Family Protein Binding
Protein K6-linked Ubiquitination
Protein K63-linked Ubiquitination
Regulation Of Post-translational Protein Modification
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Autophagy
Positive Regulation Of Catabolic Process
Protein K29-linked Ubiquitination
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Zinc Ion Binding
Cullin-RING Ubiquitin Ligase Complex
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Protein K27-linked Ubiquitination
Suppression Of Viral Release By Host
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Branched Polyubiquitination
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Stress
Regulation Of Protein Catabolic Process
Anaphase-promoting Complex
Ubiquitin Activating Enzyme Activity
Ubiquitin-like Protein Ligase Activity
Anaphase-promoting Complex-dependent Catabolic Process
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Ubiquitination
Ubiquitin-protein Transferase Activity
Proteolysis Involved In Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
Lewy Neurite
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Proteasomal Protein Catabolic Process
Ubiquitin Ligase Complex
Proteolysis
Protein Kinase C Inhibitor Activity
Negative Regulation Of Hemopoiesis
Lung Goblet Cell Differentiation
Lewy Body Core
Negative Regulation Of Immune System Process
Positive Regulation Of PERK-mediated Unfolded Protein Response
Positive Regulation Of Exit From Mitosis
Protein Catabolic Process
Negative Regulation Of Hematopoietic Stem Cell Proliferation
Negative Regulation Of Lymphocyte Activation
Positive Regulation Of Ubiquitin Protein Ligase Activity
Free Ubiquitin Chain Polymerization
Osteoclast Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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