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UBE2C and ANAPC11
Number of citations of the paper that reports this interaction (PubMedID
11739784
)
57
Data Source:
HPRD
(in vivo)
UBE2C
ANAPC11
Description
ubiquitin conjugating enzyme E2 C
anaphase promoting complex subunit 11
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Nucleolus
Cytoplasm
Cytosol
Cullin-RING Ubiquitin Ligase Complex
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin-like Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin-ubiquitin Ligase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Exit From Mitosis
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Cell Cycle
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Regulation Of Meiotic Cell Cycle
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein Branched Polyubiquitination
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Height (
31562340
)
Interacting Genes
36 interacting genes:
ANAPC11
ANAPC2
AURKA
CDC20
CKAP2
CXCR1
DTX1
ENO2
HECTD3
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
RAG1
RBX1
RELA
RNF167
RNF31
RNF6
RNF7
RYR2
STUB1
TNNC1
TRIM13
TRIM2
TRIM21
TRIM28
TRIM29
UBA1
UBA6
UBASH3B
UBC
UBE3D
58 interacting genes:
ANAPC10
ANAPC2
BANP
BEND2
CAPN11
CCNB1
CDC16
CDC20
CREB5
CRYBA2
CUL5
CYSRT1
DTX2
EFEMP1
EFEMP2
FBXO5
FOXO3
FRS3
FZR1
GPANK1
H2AC4
H2BC3
H3C1
HSD3B7
IQUB
KRTAP11-1
KRTAP13-2
KRTAP19-2
KRTAP3-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
MAK
MGAT5B
MLKL
NKD2
OXER1
P4HA3
PRKAA2
PRKAB2
PTTG1
RBPMS
RNF111
SPMIP9
TCEANC
TLE5
TRIM65
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2K
UBE2L1
UBE2S
UBE2U
WWOX
ZAP70
Entrez ID
11065
51529
HPRD ID
05717
12452
Ensembl ID
ENSG00000175063
ENSG00000141552
Uniprot IDs
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
Q9NYG5
PDB IDs
1I7K
4YII
5A31
5KHR
5L9U
8TAR
8TAU
2MT5
4R2Y
4UI9
5A31
5G04
5G05
5JG6
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
6TNT
8PKP
8TAR
8TAU
9GAW
Enriched GO Terms of Interacting Partners
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Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Ubiquitin Protein Ligase Activity
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis
Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Protein Modification Process
Catabolic Process
Protein Polyubiquitination
Protein Metabolic Process
Ubiquitin Protein Ligase Binding
Protein Autoubiquitination
Transferase Activity
Protein Monoubiquitination
Protein K48-linked Ubiquitination
Macromolecule Metabolic Process
Ubiquitin-ubiquitin Ligase Activity
Cullin Family Protein Binding
Protein K6-linked Ubiquitination
Protein K63-linked Ubiquitination
Regulation Of Post-translational Protein Modification
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Autophagy
Positive Regulation Of Catabolic Process
Protein K29-linked Ubiquitination
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Zinc Ion Binding
Cullin-RING Ubiquitin Ligase Complex
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Protein K27-linked Ubiquitination
Suppression Of Viral Release By Host
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Branched Polyubiquitination
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Stress
Regulation Of Protein Catabolic Process
Anaphase-promoting Complex
Ubiquitin Activating Enzyme Activity
Ubiquitin-like Protein Ligase Activity
Anaphase-promoting Complex-dependent Catabolic Process
Protein Polyubiquitination
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Protein Modification By Small Protein Conjugation
Anaphase-promoting Complex
Protein K11-linked Ubiquitination
Protein K48-linked Ubiquitination
Post-translational Protein Modification
Ubiquitin Conjugating Enzyme Activity
Modification-dependent Protein Catabolic Process
Protein Modification Process
Positive Regulation Of Ubiquitin Protein Ligase Activity
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Anaphase-promoting Complex Binding
Regulation Of Ubiquitin-protein Transferase Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Meiotic Cell Cycle
Proteasomal Protein Catabolic Process
Intermediate Filament
Macromolecule Catabolic Process
Proteolysis
Free Ubiquitin Chain Polymerization
Regulation Of Sister Chromatid Segregation
Positive Regulation Of Protein Ubiquitination
Regulation Of Mitotic Sister Chromatid Separation
Ubiquitin-protein Transferase Activity
Cell Division
Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Regulation Of Chromosome Segregation
Regulation Of Chromosome Separation
Protein Catabolic Process
Regulation Of Nuclear Division
Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Regulation Of Mitotic Metaphase/anaphase Transition
Cytosol
Cell Cycle Phase Transition
Regulation Of Post-translational Protein Modification
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Protein Branched Polyubiquitination
Ubiquitin-like Protein Transferase Activity
Regulation Of Reproductive Process
Positive Regulation Of Cell Cycle Phase Transition
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Nuclear Division
Positive Regulation Of Mitotic Sister Chromatid Separation
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